Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 424636..425214 Replicon chromosome
Accession NZ_LT992489
Organism Vibrio cholerae strain 4295STDY6534232

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag DG176_RS16485 Protein ID WP_001180243.1
Coordinates 424897..425214 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag DG176_RS16480 Protein ID WP_000557292.1
Coordinates 424636..424878 (+) Length 81 a.a.

Genomic Context

DG176_RS16480DG176_RS16485DG176_RS19810DG176_RS19815DG176_RS19820DG176_RS16445DG176_RS16450DG176_RS16455DG176_RS16460DG176_RS16465DG176_RS16470DG176_RS16475DG176_RS19825DG176_RS19670DG176_RS16505DG176_RS16510DG176_RS16515DG176_RS16520DG176_RS16525DG176_RS16530DG176_RS16535
Location: 424636..424878 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 424897..425214 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 420061..420099 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 420115..420240 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 420417..420527 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 420524..420841 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 420852..421139 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 421406..421586 (181 bp)
Type: Others
Protein ID: Protein_392
Location: 422011..422244 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 422647..422865 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 423175..423828 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 423885..424394 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 425408..425503 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 425859..426152 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 426299..426646 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 426795..427220 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 427416..427595 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 427892..428428 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 428572..428967 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 429144..429325 (182 bp)
Type: Others
Protein ID: Protein_406
Location: 429628..430023 (396 bp)
Type: Others
Protein ID: WP_000046952.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG176_RS19810420061..420099-39WP_106019119.1hypothetical protein-
DG176_RS19815420115..420240-126WP_001944767.1DUF645 family protein-
DG176_RS19820420417..420527-111WP_134814058.1DUF3265 domain-containing protein-
DG176_RS16445420524..420841-318WP_001232701.1HigA family addiction module antidote protein-
DG176_RS16450420852..421139-288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
DG176_RS16455421406..421586-181Protein_392DUF645 family protein-
DG176_RS16460422011..422244-234WP_032482776.1DUF3709 domain-containing protein-
DG176_RS16465422647..422865-219WP_001917086.1DUF3709 domain-containing protein-
DG176_RS16470423175..423828-654WP_000226874.1hypothetical protein-
DG176_RS16475423885..424394-510WP_000405987.1GNAT family N-acetyltransferase-
DG176_RS16480424636..424878+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
DG176_RS16485424897..425214+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DG176_RS19825425408..425503-96WP_001907607.1DUF645 family protein-
DG176_RS19670425859..426152-294WP_125460920.1hypothetical protein-
DG176_RS16505426299..426646-348WP_000933409.1hypothetical protein-
DG176_RS16510426795..427220-426WP_000403014.1GNAT family N-acetyltransferase-
DG176_RS16515427416..427595-180WP_001883039.1DUF645 family protein-
DG176_RS16520427892..428428-537WP_000644491.1nucleotidyltransferase family protein-
DG176_RS16525428572..428967-396WP_000046953.1hypothetical protein-
DG176_RS16530429144..429325-182Protein_406DUF645 family protein-
DG176_RS16535429628..430023-396WP_000046952.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-379325..47629796972
insideIntegroncatB9-379701..46950989808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T294379 WP_001180243.1 NZ_LT992489:424897-425214 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT294379 WP_000557292.1 NZ_LT992489:424636-424878 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References