38622

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 67518..68096 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag K6J77_RS14390 Protein ID WP_001180243.1
Coordinates 67518..67835 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag K6J77_RS14395 Protein ID WP_000557292.1
Coordinates 67854..68096 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J77_RS14345 62709..63104 + 396 WP_000046952.1 DUF6404 family protein -
K6J77_RS19015 63203..63346 + 144 Protein_113 acetyltransferase -
K6J77_RS14350 63469..63588 + 120 WP_001900954.1 DUF645 family protein -
K6J77_RS14355 63765..64160 + 396 WP_000046953.1 DUF6404 family protein -
K6J77_RS14360 64304..64840 + 537 WP_000644491.1 nucleotidyltransferase family protein -
K6J77_RS19020 65191..65253 + 63 Protein_117 DUF645 family protein -
K6J77_RS19025 65243..65353 + 111 WP_223804330.1 Tfp pilus assembly protein -
K6J77_RS14370 65512..65937 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
K6J77_RS14375 66086..66433 + 348 WP_000933409.1 hypothetical protein -
K6J77_RS14380 66580..66873 + 294 WP_125460920.1 hypothetical protein -
K6J77_RS19030 66936..67111 + 176 Protein_122 acetyltransferase -
K6J77_RS19035 67172..67324 + 153 Protein_123 DUF645 family protein -
K6J77_RS14390 67518..67835 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J77_RS14395 67854..68096 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6J77_RS14400 68338..68847 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
K6J77_RS14405 68904..69557 + 654 WP_000226874.1 hypothetical protein -
K6J77_RS19040 69646..69855 + 210 WP_001900246.1 DUF3709 domain-containing protein -
K6J77_RS14410 69867..70085 + 219 WP_001917086.1 DUF3709 domain-containing protein -
K6J77_RS19045 70274..70467 + 194 Protein_130 hypothetical protein -
K6J77_RS14415 70488..70721 + 234 WP_032482776.1 DUF3709 domain-containing protein -
K6J77_RS14420 71146..71326 + 181 Protein_132 DUF645 family protein -
K6J77_RS19050 71439..71552 + 114 WP_001894955.1 hypothetical protein -
K6J77_RS14425 71593..71880 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J77_RS14430 71891..72208 + 318 WP_001232701.1 HigA family addiction module antitoxin -
K6J77_RS19055 72205..72315 + 111 WP_134814058.1 DUF3265 domain-containing protein -
K6J77_RS19060 72354..72464 + 111 Protein_137 acetyltransferase -
K6J77_RS14435 72492..72617 + 126 WP_001944767.1 DUF645 family protein -
K6J77_RS19065 72580..72696 + 117 WP_001889170.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integron - - 11978..113648 101670


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T38622 WP_001180243.1 NZ_AP024548:c67835-67518 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T38622 NZ_AP024548:c67835-67518 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT38622 WP_000557292.1 NZ_AP024548:c68096-67854 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT38622 NZ_AP024548:c68096-67854 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References