Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 67518..68096 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag K6J77_RS14390 Protein ID WP_001180243.1
Coordinates 67518..67835 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag K6J77_RS14395 Protein ID WP_000557292.1
Coordinates 67854..68096 (-) Length 81 a.a.

Genomic Context

K6J77_RS14345K6J77_RS19015K6J77_RS14350K6J77_RS14355K6J77_RS14360K6J77_RS19020K6J77_RS19025K6J77_RS14370K6J77_RS14375K6J77_RS14380K6J77_RS19030K6J77_RS19035K6J77_RS14400K6J77_RS14405K6J77_RS19040K6J77_RS14410K6J77_RS19045K6J77_RS14415K6J77_RS14420K6J77_RS19050K6J77_RS14425K6J77_RS14430K6J77_RS19055K6J77_RS19060K6J77_RS14435K6J77_RS19065K6J77_RS14390K6J77_RS14395
Location: 62709..63104 (396 bp)
Type: Others
Protein ID: WP_000046952.1
Location: 63203..63346 (144 bp)
Type: Others
Protein ID: Protein_113
Location: 63469..63588 (120 bp)
Type: Others
Protein ID: WP_001900954.1
Location: 63765..64160 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 64304..64840 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 65191..65253 (63 bp)
Type: Others
Protein ID: Protein_117
Location: 65243..65353 (111 bp)
Type: Others
Protein ID: WP_223804330.1
Location: 65512..65937 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 66086..66433 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 66580..66873 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 66936..67111 (176 bp)
Type: Others
Protein ID: Protein_122
Location: 67172..67324 (153 bp)
Type: Others
Protein ID: Protein_123
Location: 68338..68847 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 68904..69557 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 69646..69855 (210 bp)
Type: Others
Protein ID: WP_001900246.1
Location: 69867..70085 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 70274..70467 (194 bp)
Type: Others
Protein ID: Protein_130
Location: 70488..70721 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 71146..71326 (181 bp)
Type: Others
Protein ID: Protein_132
Location: 71439..71552 (114 bp)
Type: Others
Protein ID: WP_001894955.1
Location: 71593..71880 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 71891..72208 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 72205..72315 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 72354..72464 (111 bp)
Type: Others
Protein ID: Protein_137
Location: 72492..72617 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 72580..72696 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 67518..67835 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 67854..68096 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J77_RS1434562709..63104+396WP_000046952.1DUF6404 family protein-
K6J77_RS1901563203..63346+144Protein_113acetyltransferase-
K6J77_RS1435063469..63588+120WP_001900954.1DUF645 family protein-
K6J77_RS1435563765..64160+396WP_000046953.1DUF6404 family protein-
K6J77_RS1436064304..64840+537WP_000644491.1nucleotidyltransferase family protein-
K6J77_RS1902065191..65253+63Protein_117DUF645 family protein-
K6J77_RS1902565243..65353+111WP_223804330.1Tfp pilus assembly protein-
K6J77_RS1437065512..65937+426WP_000403014.1GNAT family N-acetyltransferase-
K6J77_RS1437566086..66433+348WP_000933409.1hypothetical protein-
K6J77_RS1438066580..66873+294WP_125460920.1hypothetical protein-
K6J77_RS1903066936..67111+176Protein_122acetyltransferase-
K6J77_RS1903567172..67324+153Protein_123DUF645 family protein-
K6J77_RS1439067518..67835-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K6J77_RS1439567854..68096-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
K6J77_RS1440068338..68847+510WP_000405987.1GNAT family N-acetyltransferase-
K6J77_RS1440568904..69557+654WP_000226874.1hypothetical protein-
K6J77_RS1904069646..69855+210WP_001900246.1DUF3709 domain-containing protein-
K6J77_RS1441069867..70085+219WP_001917086.1DUF3709 domain-containing protein-
K6J77_RS1904570274..70467+194Protein_130hypothetical protein-
K6J77_RS1441570488..70721+234WP_032482776.1DUF3709 domain-containing protein-
K6J77_RS1442071146..71326+181Protein_132DUF645 family protein-
K6J77_RS1905071439..71552+114WP_001894955.1hypothetical protein-
K6J77_RS1442571593..71880+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J77_RS1443071891..72208+318WP_001232701.1HigA family addiction module antitoxin-
K6J77_RS1905572205..72315+111WP_134814058.1DUF3265 domain-containing protein-
K6J77_RS1906072354..72464+111Protein_137acetyltransferase-
K6J77_RS1443572492..72617+126WP_001944767.1DUF645 family protein-
K6J77_RS1906572580..72696+117WP_001889170.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegron--11978..113648101670


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T38622 WP_001180243.1 NZ_AP024548:c67835-67518 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T38622 NZ_AP024548:c67835-67518 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT38622 WP_000557292.1 NZ_AP024548:c68096-67854 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT38622 NZ_AP024548:c68096-67854 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References