Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 229321..229892 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag K6J80_RS14935 Protein ID WP_000351248.1
Coordinates 229321..229722 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag K6J80_RS18965 Protein ID WP_001080654.1
Coordinates 229722..229892 (-) Length 57 a.a.

Genomic Context

K6J80_RS14900K6J80_RS14905K6J80_RS14950K6J80_RS14890K6J80_RS14895K6J80_RS18945K6J80_RS18950K6J80_RS14910K6J80_RS18955K6J80_RS14915K6J80_RS14920K6J80_RS14925K6J80_RS14930K6J80_RS18960K6J80_RS14935K6J80_RS18965K6J80_RS18970K6J80_RS14945K6J80_RS14955K6J80_RS14960K6J80_RS14965K6J80_RS14970K6J80_RS14975K6J80_RS14980K6J80_RS14985K6J80_RS14990
Location: 225953..226225 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 226222..226719 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 230925..231905 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 224615..224902 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 225054..225722 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 225739..225801 (63 bp)
Type: Others
Protein ID: Protein_206
Location: 226736..226804 (69 bp)
Type: Others
Protein ID: Protein_209
Location: 226921..227025 (105 bp)
Type: Others
Protein ID: WP_228840819.1
Location: 227216..227338 (123 bp)
Type: Others
Protein ID: Protein_211
Location: 227395..227850 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 227978..228265 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 228255..228506 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 228720..229133 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 229208..229318 (111 bp)
Type: Others
Protein ID: WP_082798255.1
Location: 229321..229722 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 229722..229892 (171 bp)
Type: Antitoxin
Protein ID: WP_001080654.1
Location: 230016..230414 (399 bp)
Type: Others
Protein ID: Protein_219
Location: 230551..230857 (307 bp)
Type: Others
Protein ID: Protein_220
Location: 232030..232185 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 232353..232787 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 232924..233238 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 233225..233557 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 233898..234125 (228 bp)
Type: Others
Protein ID: WP_073426587.1
Location: 234074..234187 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 234353..234574 (222 bp)
Type: Others
Protein ID: WP_032468461.1
Location: 234583..234697 (115 bp)
Type: Others
Protein ID: Protein_229
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J80_RS14890224615..224902-288WP_000426470.1hypothetical protein-
K6J80_RS14895225054..225722-669WP_000043871.1hypothetical protein-
K6J80_RS18945225739..225801-63Protein_206acetyltransferase-
K6J80_RS14900225953..226225+273WP_000246253.1DUF1778 domain-containing protein-
K6J80_RS14905226222..226719+498WP_000982260.1GNAT family N-acetyltransferase-
K6J80_RS18950226736..226804-69Protein_209acetyltransferase-
K6J80_RS14910226921..227025-105WP_228840819.1DUF645 family protein-
K6J80_RS18955227216..227338-123Protein_211acetyltransferase-
K6J80_RS14915227395..227850-456WP_001245327.1GNAT family N-acetyltransferase-
K6J80_RS14920227978..228265-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J80_RS14925228255..228506-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K6J80_RS14930228720..229133-414WP_000049417.1VOC family protein-
K6J80_RS18960229208..229318-111WP_082798255.1DUF3265 domain-containing protein-
K6J80_RS14935229321..229722-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
K6J80_RS18965229722..229892-171WP_001080654.1hypothetical proteinAntitoxin
K6J80_RS18970230016..230414-399Protein_219GNAT family N-acetyltransferase-
K6J80_RS14945230551..230857-307Protein_220CatB-related O-acetyltransferase-
K6J80_RS14950230925..231905+981WP_000019370.1IS5-like element ISVch5 family transposase-
K6J80_RS14955232030..232185-156WP_000751734.1hypothetical protein-
K6J80_RS14960232353..232787-435WP_000256036.1GNAT family N-acetyltransferase-
K6J80_RS14965232924..233238-315WP_000071008.1DNA-binding transcriptional regulator-
K6J80_RS14970233225..233557-333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J80_RS14975233898..234125-228WP_073426587.1DUF1289 domain-containing protein-
K6J80_RS14980234074..234187-114WP_001889158.1hypothetical protein-
K6J80_RS14985234353..234574-222WP_032468461.1DUF1289 domain-containing protein-
K6J80_RS14990234583..234697-115Protein_229acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-213119..319686106567
insideIntegron--213119..31285699737
flankIS/Tn--230925..231905980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T38674 WP_000351248.1 NZ_AP024554:c229722-229321 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T38674 NZ_AP024554:c229722-229321 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT38674 WP_001080654.1 NZ_AP024554:c229892-229722 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT38674 NZ_AP024554:c229892-229722 [Vibrio cholerae]
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
TGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SJJ1

References