38674

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 229321..229892 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag K6J80_RS14935 Protein ID WP_000351248.1
Coordinates 229321..229722 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag K6J80_RS18965 Protein ID WP_001080654.1
Coordinates 229722..229892 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J80_RS14890 224615..224902 - 288 WP_000426470.1 hypothetical protein -
K6J80_RS14895 225054..225722 - 669 WP_000043871.1 hypothetical protein -
K6J80_RS18945 225739..225801 - 63 Protein_206 acetyltransferase -
K6J80_RS14900 225953..226225 + 273 WP_000246253.1 DUF1778 domain-containing protein -
K6J80_RS14905 226222..226719 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
K6J80_RS18950 226736..226804 - 69 Protein_209 acetyltransferase -
K6J80_RS14910 226921..227025 - 105 WP_228840819.1 DUF645 family protein -
K6J80_RS18955 227216..227338 - 123 Protein_211 acetyltransferase -
K6J80_RS14915 227395..227850 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
K6J80_RS14920 227978..228265 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J80_RS14925 228255..228506 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J80_RS14930 228720..229133 - 414 WP_000049417.1 VOC family protein -
K6J80_RS18960 229208..229318 - 111 WP_082798255.1 DUF3265 domain-containing protein -
K6J80_RS14935 229321..229722 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
K6J80_RS18965 229722..229892 - 171 WP_001080654.1 hypothetical protein Antitoxin
K6J80_RS18970 230016..230414 - 399 Protein_219 GNAT family N-acetyltransferase -
K6J80_RS14945 230551..230857 - 307 Protein_220 CatB-related O-acetyltransferase -
K6J80_RS14950 230925..231905 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
K6J80_RS14955 232030..232185 - 156 WP_000751734.1 hypothetical protein -
K6J80_RS14960 232353..232787 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
K6J80_RS14965 232924..233238 - 315 WP_000071008.1 DNA-binding transcriptional regulator -
K6J80_RS14970 233225..233557 - 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J80_RS14975 233898..234125 - 228 WP_073426587.1 DUF1289 domain-containing protein -
K6J80_RS14980 234074..234187 - 114 WP_001889158.1 hypothetical protein -
K6J80_RS14985 234353..234574 - 222 WP_032468461.1 DUF1289 domain-containing protein -
K6J80_RS14990 234583..234697 - 115 Protein_229 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 213119..319686 106567
inside Integron - - 213119..312856 99737
flank IS/Tn - - 230925..231905 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T38674 WP_000351248.1 NZ_AP024554:c229722-229321 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T38674 NZ_AP024554:c229722-229321 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT38674 WP_001080654.1 NZ_AP024554:c229892-229722 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT38674 NZ_AP024554:c229892-229722 [Vibrio cholerae]
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
TGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References