104251

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 345550..346109 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag N16961_RS15750 Protein ID WP_000578476.1
Coordinates 345550..345828 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag N16961_RS15755 Protein ID WP_000381183.1
Coordinates 345825..346109 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N16961_RS15695 340628..341134 + 507 WP_000393074.1 hypothetical protein -
N16961_RS15700 341291..341677 + 387 WP_000703163.1 VOC family protein -
N16961_RS15705 341934..342137 + 204 WP_001911580.1 hypothetical protein -
N16961_RS15710 342332..342583 + 252 WP_001890111.1 TIGR03643 family protein -
N16961_RS15715 342556..342705 + 150 WP_071908333.1 DUF3265 domain-containing protein -
N16961_RS15720 342852..343277 + 426 WP_000415750.1 hypothetical protein -
N16961_RS15725 343483..344106 + 624 WP_000247070.1 DUF1349 domain-containing protein -
N16961_RS15730 344319..344798 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
N16961_RS15740 344986..345399 + 414 WP_000049420.1 VOC family protein -
N16961_RS15750 345550..345828 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
N16961_RS15755 345825..346109 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N16961_RS15760 346304..346819 + 516 WP_001201520.1 lipocalin family protein -
N16961_RS15765 346884..347480 + 597 WP_000255434.1 hypothetical protein -
N16961_RS15775 347872..348054 + 183 WP_000923182.1 DUF645 family protein -
N16961_RS15780 348254..348727 + 474 WP_001161076.1 GrpB family protein -
N16961_RS15785 348742..348834 + 93 WP_014378730.1 DUF3265 domain-containing protein -
N16961_RS15790 348876..349502 + 627 WP_000365424.1 LysE family translocator -
N16961_RS15795 349625..350323 + 699 WP_001890502.1 hypothetical protein -
N16961_RS15800 350333..350443 + 111 WP_079857360.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306977..438073 131096
inside Integron - - 312057..437697 125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T104251 WP_000578476.1 NZ_CP028828:c345828-345550 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T104251 NZ_CP028828:c345828-345550 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT104251 WP_000381183.1 NZ_CP028828:c346109-345825 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT104251 NZ_CP028828:c346109-345825 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References