Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 203550..204048 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag EEL44_RS01360 Protein ID WP_000589156.1
Coordinates 203782..204048 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag EEL44_RS01355 Protein ID WP_000643598.1
Coordinates 203550..203795 (-) Length 82 a.a.

Genomic Context

EEL44_RS01310EEL44_RS01315EEL44_RS01320EEL44_RS01325EEL44_RS01330EEL44_RS01335EEL44_RS01340EEL44_RS01350EEL44_RS01355EEL44_RS01360EEL44_RS01370EEL44_RS01375EEL44_RS20970EEL44_RS20975EEL44_RS01395EEL44_RS01400EEL44_RS01405EEL44_RS01410EEL44_RS01415EEL44_RS01420EEL44_RS01425
Location: 198631..199017 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 199174..199680 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 199948..200181 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 200454..200813 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 200966..201970 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 202186..202368 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 202429..202557 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 202660..203454 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 203550..203795 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 203782..204048 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 204233..204895 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 205023..205490 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 205702..205740 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 205794..205937 (144 bp)
Type: Others
Protein ID: Protein_245
Location: 206312..206590 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 206842..207084 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 207176..207325 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 207298..207549 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 207744..208130 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 208120..208221 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 208421..208627 (207 bp)
Type: Others
Protein ID: Protein_252
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EEL44_RS01310198631..199017-387WP_000703163.1VOC family protein-
EEL44_RS01315199174..199680-507WP_000393074.1hypothetical protein-
EEL44_RS01320199948..200181-234WP_001890112.1DUF3709 domain-containing protein-
EEL44_RS01325200454..200813-360WP_001071541.1VOC family protein-
EEL44_RS01330200966..201970-1005WP_000964920.1LD-carboxypeptidase-
EEL44_RS01335202186..202368-183WP_000923182.1DUF645 family protein-
EEL44_RS01340202429..202557-129WP_071908338.1general secretion pathway protein GspI-
EEL44_RS01350202660..203454-795WP_001911581.1hypothetical protein-
EEL44_RS01355203550..203795-246WP_000643598.1hypothetical proteinAntitoxin
EEL44_RS01360203782..204048-267WP_000589156.1BrnT family toxinToxin
EEL44_RS01370204233..204895-663WP_000960654.1hypothetical protein-
EEL44_RS01375205023..205490-468WP_001289288.1OsmC family protein-
EEL44_RS20970205702..205740-39WP_082798268.1hypothetical protein-
EEL44_RS20975205794..205937-144Protein_245DUF645 family protein-
EEL44_RS01395206312..206590-279WP_000280324.1DUF3709 domain-containing protein-
EEL44_RS01400206842..207084-243WP_000107461.1hypothetical protein-
EEL44_RS01405207176..207325-150WP_071908333.1DUF3265 domain-containing protein-
EEL44_RS01410207298..207549-252WP_001890111.1TIGR03643 family protein-
EEL44_RS01415207744..208130-387WP_000703163.1VOC family protein-
EEL44_RS01420208120..208221-102WP_001921603.1hypothetical protein-
EEL44_RS01425208421..208627-207Protein_252DUF3709 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-126763..233717106954
insideIntegron--127139..22687599736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T113808 WP_000589156.1 NZ_CP033513:c204048-203782 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T113808 NZ_CP033513:c204048-203782 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT113808 WP_000643598.1 NZ_CP033513:c203795-203550 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT113808 NZ_CP033513:c203795-203550 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References