113808

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 203550..204048 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag EEL44_RS01360 Protein ID WP_000589156.1
Coordinates 203782..204048 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag EEL44_RS01355 Protein ID WP_000643598.1
Coordinates 203550..203795 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EEL44_RS01310 198631..199017 - 387 WP_000703163.1 VOC family protein -
EEL44_RS01315 199174..199680 - 507 WP_000393074.1 hypothetical protein -
EEL44_RS01320 199948..200181 - 234 WP_001890112.1 DUF3709 domain-containing protein -
EEL44_RS01325 200454..200813 - 360 WP_001071541.1 VOC family protein -
EEL44_RS01330 200966..201970 - 1005 WP_000964920.1 LD-carboxypeptidase -
EEL44_RS01335 202186..202368 - 183 WP_000923182.1 DUF645 family protein -
EEL44_RS01340 202429..202557 - 129 WP_071908338.1 general secretion pathway protein GspI -
EEL44_RS01350 202660..203454 - 795 WP_001911581.1 hypothetical protein -
EEL44_RS01355 203550..203795 - 246 WP_000643598.1 hypothetical protein Antitoxin
EEL44_RS01360 203782..204048 - 267 WP_000589156.1 BrnT family toxin Toxin
EEL44_RS01370 204233..204895 - 663 WP_000960654.1 hypothetical protein -
EEL44_RS01375 205023..205490 - 468 WP_001289288.1 OsmC family protein -
EEL44_RS20970 205702..205740 - 39 WP_082798268.1 hypothetical protein -
EEL44_RS20975 205794..205937 - 144 Protein_245 DUF645 family protein -
EEL44_RS01395 206312..206590 - 279 WP_000280324.1 DUF3709 domain-containing protein -
EEL44_RS01400 206842..207084 - 243 WP_000107461.1 hypothetical protein -
EEL44_RS01405 207176..207325 - 150 WP_071908333.1 DUF3265 domain-containing protein -
EEL44_RS01410 207298..207549 - 252 WP_001890111.1 TIGR03643 family protein -
EEL44_RS01415 207744..208130 - 387 WP_000703163.1 VOC family protein -
EEL44_RS01420 208120..208221 - 102 WP_001921603.1 hypothetical protein -
EEL44_RS01425 208421..208627 - 207 Protein_252 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 126763..233717 106954
inside Integron - - 127139..226875 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T113808 WP_000589156.1 NZ_CP033513:c204048-203782 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T113808 NZ_CP033513:c204048-203782 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT113808 WP_000643598.1 NZ_CP033513:c203795-203550 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT113808 NZ_CP033513:c203795-203550 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References