Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 333842..334340 Replicon chromosome
Accession NZ_CP047302
Organism Vibrio cholerae O1 biovar El Tor strain DRC-193A

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag GTF75_RS15425 Protein ID WP_000589156.1
Coordinates 333842..334108 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag GTF75_RS15430 Protein ID WP_000643598.1
Coordinates 334095..334340 (+) Length 82 a.a.

Genomic Context

GTF75_RS15370GTF75_RS15375GTF75_RS15380GTF75_RS15385GTF75_RS15390GTF75_RS15395GTF75_RS15400GTF75_RS15405GTF75_RS15410GTF75_RS15415GTF75_RS15420GTF75_RS15425GTF75_RS15430GTF75_RS15435GTF75_RS15440GTF75_RS15445GTF75_RS15450GTF75_RS15455GTF75_RS15460GTF75_RS15465GTF75_RS15470
Location: 329263..329469 (207 bp)
Type: Others
Protein ID: Protein_293
Location: 329669..329770 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 329760..330146 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 330341..330592 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 330565..330714 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 330806..331048 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 331300..331578 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 331953..332096 (144 bp)
Type: Others
Protein ID: Protein_300
Location: 332150..332188 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 332400..332867 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 332995..333657 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 333842..334108 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 334095..334340 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 334436..335230 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 335333..335461 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 335522..335704 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 335920..336924 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 337077..337436 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 337709..337942 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 338210..338716 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 338873..339259 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF75_RS15370329263..329469+207Protein_293DUF3709 domain-containing protein-
GTF75_RS15375329669..329770+102WP_001921603.1hypothetical protein-
GTF75_RS15380329760..330146+387WP_000703163.1VOC family protein-
GTF75_RS15385330341..330592+252WP_001890111.1TIGR03643 family protein-
GTF75_RS15390330565..330714+150WP_071908333.1DUF3265 domain-containing protein-
GTF75_RS15395330806..331048+243WP_000107461.1hypothetical protein-
GTF75_RS15400331300..331578+279WP_000280324.1DUF3709 domain-containing protein-
GTF75_RS15405331953..332096+144Protein_300DUF645 family protein-
GTF75_RS15410332150..332188+39WP_082798268.1hypothetical protein-
GTF75_RS15415332400..332867+468WP_001289288.1OsmC family protein-
GTF75_RS15420332995..333657+663WP_000960654.1hypothetical protein-
GTF75_RS15425333842..334108+267WP_000589156.1BrnT family toxinToxin
GTF75_RS15430334095..334340+246WP_000643598.1hypothetical proteinAntitoxin
GTF75_RS15435334436..335230+795WP_001911581.1hypothetical protein-
GTF75_RS15440335333..335461+129WP_071908338.1general secretion pathway protein GspI-
GTF75_RS15445335522..335704+183WP_000923182.1DUF645 family protein-
GTF75_RS15450335920..336924+1005WP_000964920.1LD-carboxypeptidase-
GTF75_RS15455337077..337436+360WP_001071541.1VOC family protein-
GTF75_RS15460337709..337942+234WP_001890112.1DUF3709 domain-containing protein-
GTF75_RS15465338210..338716+507WP_000393074.1hypothetical protein-
GTF75_RS15470338873..339259+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-305935..411136105201
insideIntegron--311015..41076099745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T145867 WP_000589156.1 NZ_CP047302:333842-334108 [Vibrio cholerae O1 biovar El Tor]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T145867 NZ_CP062705:c710184-709720 [Escherichia coli O157:H7]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT145867 WP_000643598.1 NZ_CP047302:334095-334340 [Vibrio cholerae O1 biovar El Tor]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT145867 NZ_CP062705:c710519-710184 [Escherichia coli O157:H7]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAGCAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References