25713

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 99835..100363 Replicon chromosome
Accession NC_016446
Organism Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag HJ37_RS14645 Protein ID WP_000221352.1
Coordinates 99835..100125 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag HJ37_RS14650 Protein ID WP_000213183.1
Coordinates 100115..100363 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ37_RS20215 95105..95215 + 111 WP_134814058.1 DUF3265 domain-containing protein -
HJ37_RS19525 95392..95517 + 126 WP_001944767.1 DUF645 family protein -
HJ37_RS19980 95533..95571 + 39 WP_106019119.1 hypothetical protein -
HJ37_RS14620 95784..96788 + 1005 WP_000964925.1 LD-carboxypeptidase -
HJ37_RS14625 96941..97387 + 447 WP_000128977.1 hypothetical protein -
HJ37_RS14630 97507..98436 + 930 WP_000335802.1 hypothetical protein -
HJ37_RS19985 98433..98543 + 111 WP_071917832.1 DUF3265 domain-containing protein -
HJ37_RS14635 98571..99047 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
HJ37_RS14640 99184..99699 + 516 WP_001201528.1 lipocalin family protein -
HJ37_RS14645 99835..100125 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HJ37_RS14650 100115..100363 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HJ37_RS14665 100934..101587 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
HJ37_RS14670 101859..102284 + 426 WP_000415748.1 hypothetical protein -
HJ37_RS14675 102492..102887 + 396 WP_000649527.1 DUF3465 domain-containing protein -
HJ37_RS14680 103038..103568 + 531 WP_000415563.1 hypothetical protein -
HJ37_RS14685 103706..104206 + 501 WP_000789723.1 hypothetical protein -
HJ37_RS14690 104362..104760 + 399 WP_001882293.1 hypothetical protein -
HJ37_RS14695 104860..105324 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31115..136304 105189
inside Integron catB9 - 36195..135928 99733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T25713 WP_000221352.1 NC_016446:c100125-99835 [Vibrio cholerae O1 str. 2010EL-1786]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T25713 NC_016446:c100125-99835 [Vibrio cholerae O1 str. 2010EL-1786]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT25713 WP_000213183.1 NC_016446:c100363-100115 [Vibrio cholerae O1 str. 2010EL-1786]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT25713 NC_016446:c100363-100115 [Vibrio cholerae O1 str. 2010EL-1786]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References