Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 99835..100363 Replicon chromosome
Accession NC_016446
Organism Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag HJ37_RS14645 Protein ID WP_000221352.1
Coordinates 99835..100125 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag HJ37_RS14650 Protein ID WP_000213183.1
Coordinates 100115..100363 (-) Length 83 a.a.

Genomic Context

HJ37_RS20215HJ37_RS19525HJ37_RS19980HJ37_RS14620HJ37_RS14625HJ37_RS14630HJ37_RS19985HJ37_RS14635HJ37_RS14640HJ37_RS14665HJ37_RS14670HJ37_RS14675HJ37_RS14680HJ37_RS14685HJ37_RS14690HJ37_RS14645HJ37_RS14650HJ37_RS14695
Location: 95105..95215 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 95392..95517 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 95533..95571 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 95784..96788 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 96941..97387 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 97507..98436 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 98433..98543 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 98571..99047 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 99184..99699 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 100934..101587 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 101859..102284 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 102492..102887 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 103038..103568 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 103706..104206 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 104362..104760 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 99835..100125 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 100115..100363 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 104860..105324 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HJ37_RS2021595105..95215+111WP_134814058.1DUF3265 domain-containing protein-
HJ37_RS1952595392..95517+126WP_001944767.1DUF645 family protein-
HJ37_RS1998095533..95571+39WP_106019119.1hypothetical protein-
HJ37_RS1462095784..96788+1005WP_000964925.1LD-carboxypeptidase-
HJ37_RS1462596941..97387+447WP_000128977.1hypothetical protein-
HJ37_RS1463097507..98436+930WP_000335802.1hypothetical protein-
HJ37_RS1998598433..98543+111WP_071917832.1DUF3265 domain-containing protein-
HJ37_RS1463598571..99047+477WP_001047180.1GNAT family N-acetyltransferase-
HJ37_RS1464099184..99699+516WP_001201528.1lipocalin family protein-
HJ37_RS1464599835..100125-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HJ37_RS14650100115..100363-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
HJ37_RS14665100934..101587+654WP_000036957.1site-specific DNA-methyltransferase-
HJ37_RS14670101859..102284+426WP_000415748.1hypothetical protein-
HJ37_RS14675102492..102887+396WP_000649527.1DUF3465 domain-containing protein-
HJ37_RS14680103038..103568+531WP_000415563.1hypothetical protein-
HJ37_RS14685103706..104206+501WP_000789723.1hypothetical protein-
HJ37_RS14690104362..104760+399WP_001882293.1hypothetical protein-
HJ37_RS14695104860..105324-465WP_000140244.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31115..136304105189
insideIntegroncatB9-36195..13592899733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T25713 WP_000221352.1 NC_016446:c100125-99835 [Vibrio cholerae O1 str. 2010EL-1786]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T25713 NC_016446:c100125-99835 [Vibrio cholerae O1 str. 2010EL-1786]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT25713 WP_000213183.1 NC_016446:c100363-100115 [Vibrio cholerae O1 str. 2010EL-1786]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT25713 NC_016446:c100363-100115 [Vibrio cholerae O1 str. 2010EL-1786]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References