Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 737137..737677 Replicon chromosome
Accession NZ_CP102928
Organism Vibrio cholerae strain N1252

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag NW313_RS17155 Protein ID WP_000277238.1
Coordinates 737137..737406 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag NW313_RS17160 Protein ID WP_001258569.1
Coordinates 737399..737677 (-) Length 93 a.a.

Genomic Context

NW313_RS17115NW313_RS17120NW313_RS17125NW313_RS17140NW313_RS17145NW313_RS17150NW313_RS17165NW313_RS17170NW313_RS17175NW313_RS17180NW313_RS17185NW313_RS17190NW313_RS17195NW313_RS17200NW313_RS17205NW313_RS17210NW313_RS17215NW313_RS17220NW313_RS17225NW313_RS17130NW313_RS17135NW313_RS17155NW313_RS17160
Location: 732358..732894 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 733085..733546 (462 bp)
Type: Others
Protein ID: WP_001903091.1
Location: 733611..733679 (69 bp)
Type: Others
Protein ID: Protein_648
Location: 734855..734980 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 735230..735676 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 735739..736950 (1212 bp)
Type: Others
Protein ID: WP_001122813.1
Location: 737728..737845 (118 bp)
Type: Others
Protein ID: Protein_656
Location: 737963..738241 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 738601..738699 (99 bp)
Type: Others
Protein ID: WP_223225486.1
Location: 738899..739000 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 738990..739376 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 739571..739822 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 739795..739944 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 740036..740278 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 740530..740808 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 741240..741283 (44 bp)
Type: Others
Protein ID: Protein_665
Location: 741265..741358 (94 bp)
Type: Others
Protein ID: Protein_666
Location: 741327..741458 (132 bp)
Type: Others
Protein ID: WP_001883067.1
Location: 741630..742097 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 733696..734193 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 734190..734462 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 737137..737406 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 737399..737677 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NW313_RS17115732358..732894+537WP_000469482.1GNAT family protein-
NW313_RS17120733085..733546+462WP_001903091.1lipocalin family protein-
NW313_RS17125733611..733679+69Protein_648acetyltransferase-
NW313_RS17130733696..734193-498WP_000982260.1GNAT family N-acetyltransferase-
NW313_RS17135734190..734462-273WP_000246253.1DUF1778 domain-containing protein-
NW313_RS17140734855..734980+126WP_001900195.1DUF645 family protein-
NW313_RS17145735230..735676+447WP_000006157.1hypothetical protein-
NW313_RS17150735739..736950+1212WP_001122813.1IS256 family transposase-
NW313_RS17155737137..737406-270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
NW313_RS17160737399..737677-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
NW313_RS17165737728..737845+118Protein_656DUF3265 domain-containing protein-
NW313_RS17170737963..738241+279WP_001921601.1DUF3709 domain-containing protein-
NW313_RS17175738601..738699+99WP_223225486.1DUF3709 domain-containing protein-
NW313_RS17180738899..739000+102WP_001921603.1hypothetical protein-
NW313_RS17185738990..739376+387WP_000703163.1VOC family protein-
NW313_RS17190739571..739822+252WP_001890111.1TIGR03643 family protein-
NW313_RS17195739795..739944+150WP_071908333.1DUF3265 domain-containing protein-
NW313_RS17200740036..740278+243WP_000107461.1hypothetical protein-
NW313_RS17205740530..740808+279WP_000280324.1DUF3709 domain-containing protein-
NW313_RS17210741240..741283+44Protein_665hypothetical protein-
NW313_RS17215741265..741358+94Protein_666ggdef family protein-
NW313_RS17220741327..741458+132WP_001883067.1hypothetical protein-
NW313_RS17225741630..742097+468WP_001289288.1OsmC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-713852..820357106505
insideIntegroncatB9-718932..819981101049
-flankIS/Tn--735739..7369501211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T254467 WP_000277238.1 NZ_CP102928:c737406-737137 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT254467 WP_001258569.1 NZ_CP102928:c737677-737399 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References