Detailed information of TA system TA145405

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 399866..400821
• Replicon: chromosome
• Accession: NZ_CP047060
• Organism: Vibrio cholerae isolate CTMA_1441

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KM94
• Locus tag: GQX72_RS15950
• Protein ID: WP_000118351.1
• Coordinates: 400288..400821 (+)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: GQX72_RS19055
• Protein ID: WP_001882332.1
• Coordinates: 399866..400291 (+)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQX72_RS15895	395396..395647	+	252	WP_001250179.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
GQX72_RS15900	395637..395924	+	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GQX72_RS15905	396052..396507	+	456	WP_001245327.1	GNAT family N-acetyltransferase	-
GQX72_RS15910	396829..396981	+	153	WP_001884520.1	DUF645 family protein	-
GQX72_RS15920	397183..397680	-	498	WP_000982260.1	GNAT family N-acetyltransferase	-
GQX72_RS15925	397677..397949	-	273	WP_000246253.1	DUF1778 domain-containing protein	-
GQX72_RS15930	398180..398848	+	669	WP_000043871.1	hypothetical protein	-
GQX72_RS15935	399000..399287	+	288	WP_000426470.1	hypothetical protein	-
GQX72_RS15940	399428..399799	+	372	WP_001164080.1	nucleotide pyrophosphohydrolase	-
GQX72_RS19055	399866..400291	+	426	WP_001882332.1	DUF1778 domain-containing protein	Antitoxin
GQX72_RS15950	400288..400821	+	534	WP_000118351.1	GNAT family N-acetyltransferase	Toxin
GQX72_RS15960	401023..401280	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
GQX72_RS15965	401268..401570	+	303	WP_000229317.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GQX72_RS15970	401804..402721	+	918	WP_000186333.1	alpha/beta hydrolase	-
GQX72_RS15975	402878..403267	+	390	WP_001081302.1	hypothetical protein	-
GQX72_RS15980	403403..403612	+	210	Protein_424	GNAT family N-acetyltransferase	-
GQX72_RS15985	403731..404168	+	438	WP_000503164.1	IS200/IS605-like element IS1004 family transposase	-
GQX72_RS15990	404232..404450	+	219	WP_071908318.1	GNAT family N-acetyltransferase	-
GQX72_RS15995	404625..405497	+	873	WP_000254716.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	305960..411159	105199
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.004	inside	Integron	-	-	311040..410783	99743
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000179, TA000177, TA000178, TA010035 428335..428772 0.002	flank	IS/Tn	-	-	403731..404168	437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (57-133)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20171.46 Da
• Isoelectric Point: 9.1432

>T145405 WP_000118351.1 NZ_CP047060:400288-400821 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Nucleotide

• Length: 534 bp

>T145405 NZ_CP062376:2582532-2582636 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15714.41 Da
• Isoelectric Point: 7.6659

>AT145405 WP_001882332.1 NZ_CP047060:399866-400291 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Nucleotide

• Length: 426 bp

>AT145405 NZ_CP062376:c2582794-2582631 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: Q9KM94