Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 341455..342014 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag VCA1552_RS15960 Protein ID WP_000578476.1
Coordinates 341455..341733 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag VCA1552_RS15965 Protein ID WP_000381183.1
Coordinates 341730..342014 (-) Length 95 a.a.

Genomic Context

VCA1552_RS15905VCA1552_RS15910VCA1552_RS15915VCA1552_RS15920VCA1552_RS15925VCA1552_RS15930VCA1552_RS15935VCA1552_RS15940VCA1552_RS15950VCA1552_RS15970VCA1552_RS15975VCA1552_RS15985VCA1552_RS15990VCA1552_RS15995VCA1552_RS16000VCA1552_RS16005VCA1552_RS16010VCA1552_RS15960VCA1552_RS15965
Location: 336492..336725 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 336993..337499 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 337656..338042 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 338237..338488 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 338461..338610 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 338757..339182 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 339388..340011 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 340224..340703 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 340891..341304 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 342209..342724 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 342789..343385 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 343777..343959 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 344159..344632 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 344629..344739 (111 bp)
Type: Others
Protein ID: WP_071908312.1
Location: 344781..345407 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 345530..346228 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 346232..346348 (117 bp)
Type: Others
Protein ID: WP_071908339.1
Location: 341455..341733 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 341730..342014 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCA1552_RS15905336492..336725+234WP_001890112.1DUF3709 domain-containing protein-
VCA1552_RS15910336993..337499+507WP_000393074.1hypothetical protein-
VCA1552_RS15915337656..338042+387WP_000703163.1VOC family protein-
VCA1552_RS15920338237..338488+252WP_001890111.1TIGR03643 family protein-
VCA1552_RS15925338461..338610+150WP_071908333.1DUF3265 domain-containing protein-
VCA1552_RS15930338757..339182+426WP_000415750.1hypothetical protein-
VCA1552_RS15935339388..340011+624WP_000247070.1DUF1349 domain-containing protein-
VCA1552_RS15940340224..340703+480WP_000009888.1lecithin retinol acyltransferase family protein-
VCA1552_RS15950340891..341304+414WP_000049420.1VOC family protein-
VCA1552_RS15960341455..341733-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
VCA1552_RS15965341730..342014-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
VCA1552_RS15970342209..342724+516WP_001201520.1lipocalin family protein-
VCA1552_RS15975342789..343385+597WP_000255434.1hypothetical protein-
VCA1552_RS15985343777..343959+183WP_000923182.1DUF645 family protein-
VCA1552_RS15990344159..344632+474WP_001161076.1GrpB family protein-
VCA1552_RS15995344629..344739+111WP_071908312.1DUF3265 domain-containing protein-
VCA1552_RS16000344781..345407+627WP_000365424.1LysE family translocator-
VCA1552_RS16005345530..346228+699WP_001890502.1hypothetical protein-
VCA1552_RS16010346232..346348+117WP_071908339.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304717..433978129261
insideIntegron--309797..433602123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T88991 WP_000578476.1 NZ_CP024868:c341733-341455 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T88991 NZ_CP024868:c341733-341455 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT88991 WP_000381183.1 NZ_CP024868:c342014-341730 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT88991 NZ_CP024868:c342014-341730 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References