88991

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 341455..342014 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag VCA1552_RS15960 Protein ID WP_000578476.1
Coordinates 341455..341733 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag VCA1552_RS15965 Protein ID WP_000381183.1
Coordinates 341730..342014 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCA1552_RS15905 336492..336725 + 234 WP_001890112.1 DUF3709 domain-containing protein -
VCA1552_RS15910 336993..337499 + 507 WP_000393074.1 hypothetical protein -
VCA1552_RS15915 337656..338042 + 387 WP_000703163.1 VOC family protein -
VCA1552_RS15920 338237..338488 + 252 WP_001890111.1 TIGR03643 family protein -
VCA1552_RS15925 338461..338610 + 150 WP_071908333.1 DUF3265 domain-containing protein -
VCA1552_RS15930 338757..339182 + 426 WP_000415750.1 hypothetical protein -
VCA1552_RS15935 339388..340011 + 624 WP_000247070.1 DUF1349 domain-containing protein -
VCA1552_RS15940 340224..340703 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
VCA1552_RS15950 340891..341304 + 414 WP_000049420.1 VOC family protein -
VCA1552_RS15960 341455..341733 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
VCA1552_RS15965 341730..342014 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
VCA1552_RS15970 342209..342724 + 516 WP_001201520.1 lipocalin family protein -
VCA1552_RS15975 342789..343385 + 597 WP_000255434.1 hypothetical protein -
VCA1552_RS15985 343777..343959 + 183 WP_000923182.1 DUF645 family protein -
VCA1552_RS15990 344159..344632 + 474 WP_001161076.1 GrpB family protein -
VCA1552_RS15995 344629..344739 + 111 WP_071908312.1 DUF3265 domain-containing protein -
VCA1552_RS16000 344781..345407 + 627 WP_000365424.1 LysE family translocator -
VCA1552_RS16005 345530..346228 + 699 WP_001890502.1 hypothetical protein -
VCA1552_RS16010 346232..346348 + 117 WP_071908339.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304717..433978 129261
inside Integron - - 309797..433602 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T88991 WP_000578476.1 NZ_CP024868:c341733-341455 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T88991 NZ_CP024868:c341733-341455 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT88991 WP_000381183.1 NZ_CP024868:c342014-341730 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT88991 NZ_CP024868:c342014-341730 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References