Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 356212..356790 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ79_RS15935 Protein ID WP_001180243.1
Coordinates 356212..356529 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ79_RS15940 Protein ID WP_000557292.1
Coordinates 356548..356790 (-) Length 81 a.a.

Genomic Context

ASZ79_RS15905ASZ79_RS15910ASZ79_RS15915ASZ79_RS15920ASZ79_RS15925ASZ79_RS15930ASZ79_RS15945ASZ79_RS15950ASZ79_RS15955ASZ79_RS15965ASZ79_RS15970ASZ79_RS20555ASZ79_RS20560ASZ79_RS15990ASZ79_RS15935ASZ79_RS15940ASZ79_RS15975ASZ79_RS15980
Location: 351736..351918 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 352272..352454 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 352649..353326 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 353488..354696 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 354858..355562 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 355720..356058 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 357034..357420 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 357477..357590 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 357539..357820 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 358078..358614 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 358751..359266 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 360575..360700 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 360716..360754 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 360950..361396 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 356212..356529 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 356548..356790 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 359416..359913 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 359910..360182 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ79_RS15905351736..351918+183WP_000923340.1DUF645 family protein-
ASZ79_RS15910352272..352454+183WP_000923153.1DUF645 family protein-
ASZ79_RS15915352649..353326+678WP_000254617.1HNH endonuclease-
ASZ79_RS15920353488..354696+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
ASZ79_RS15925354858..355562+705WP_000087610.1HNH endonuclease-
ASZ79_RS15930355720..356058+339WP_000713853.1hypothetical protein-
ASZ79_RS15935356212..356529-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ79_RS15940356548..356790-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ79_RS15945357034..357420+387WP_001015867.1NUDIX hydrolase-
ASZ79_RS15950357477..357590+114WP_001900214.1hypothetical protein-
ASZ79_RS15955357539..357820+282WP_001894429.1DUF1289 domain-containing protein-
ASZ79_RS15965358078..358614+537WP_000469482.1GNAT family N-acetyltransferase-
ASZ79_RS15970358751..359266+516WP_001201509.1lipocalin family protein-
ASZ79_RS15975359416..359913-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ79_RS15980359910..360182-273WP_000246253.1DUF1778 domain-containing protein-
ASZ79_RS20555360575..360700+126WP_001900195.1DUF645 family protein-
ASZ79_RS20560360716..360754+39WP_106019118.1hypothetical protein-
ASZ79_RS15990360950..361396+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..468464163764
insideIntegron--309780..468088158308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58353 WP_001180243.1 NZ_CP013314:c356529-356212 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58353 NZ_CP013314:c356529-356212 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58353 WP_000557292.1 NZ_CP013314:c356790-356548 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58353 NZ_CP013314:c356790-356548 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References