58353

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 356212..356790 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ79_RS15935 Protein ID WP_001180243.1
Coordinates 356212..356529 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ79_RS15940 Protein ID WP_000557292.1
Coordinates 356548..356790 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ79_RS15905 351736..351918 + 183 WP_000923340.1 DUF645 family protein -
ASZ79_RS15910 352272..352454 + 183 WP_000923153.1 DUF645 family protein -
ASZ79_RS15915 352649..353326 + 678 WP_000254617.1 HNH endonuclease -
ASZ79_RS15920 353488..354696 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
ASZ79_RS15925 354858..355562 + 705 WP_000087610.1 HNH endonuclease -
ASZ79_RS15930 355720..356058 + 339 WP_000713853.1 hypothetical protein -
ASZ79_RS15935 356212..356529 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ79_RS15940 356548..356790 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ79_RS15945 357034..357420 + 387 WP_001015867.1 NUDIX hydrolase -
ASZ79_RS15950 357477..357590 + 114 WP_001900214.1 hypothetical protein -
ASZ79_RS15955 357539..357820 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ79_RS15965 358078..358614 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ79_RS15970 358751..359266 + 516 WP_001201509.1 lipocalin family protein -
ASZ79_RS15975 359416..359913 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ79_RS15980 359910..360182 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ79_RS20555 360575..360700 + 126 WP_001900195.1 DUF645 family protein -
ASZ79_RS20560 360716..360754 + 39 WP_106019118.1 hypothetical protein -
ASZ79_RS15990 360950..361396 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..468464 163764
inside Integron - - 309780..468088 158308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58353 WP_001180243.1 NZ_CP013314:c356529-356212 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58353 NZ_CP013314:c356529-356212 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58353 WP_000557292.1 NZ_CP013314:c356790-356548 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58353 NZ_CP013314:c356790-356548 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References