Detailed information of TA system TA104351

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 431454..432238
• Replicon: chromosome
• Accession: NZ_CP028895
• Organism: Vibrio cholerae strain A1552

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: A1552VC_RS16900
• Protein ID: WP_001114075.1
• Coordinates: 431454..431723 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: Q9KM84
• Locus tag: A1552VC_RS16905
• Protein ID: WP_000921691.1
• Coordinates: 431717..432238 (+)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A1552VC_RS16860	426820..427737	+	918	WP_000186333.1	alpha/beta hydrolase	-
A1552VC_RS16865	427894..428283	+	390	WP_001081302.1	hypothetical protein	-
A1552VC_RS16870	428419..428628	+	210	Protein_465	GNAT family N-acetyltransferase	-
A1552VC_RS16875	428747..429184	+	438	WP_000503169.1	IS200/IS605-like element IS1004 family transposase	-
A1552VC_RS16880	429248..429466	+	219	WP_071908318.1	GNAT family N-acetyltransferase	-
A1552VC_RS16885	429641..430513	+	873	WP_000254716.1	DUF3800 domain-containing protein	-
A1552VC_RS16890	430663..431262	+	600	WP_001891245.1	glutathione S-transferase N-terminal domain-containing protein	-
A1552VC_RS16895	431319..431423	+	105	WP_099607150.1	acetyltransferase	-
A1552VC_RS16900	431454..431723	+	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
A1552VC_RS16905	431717..432238	+	522	WP_000921691.1	DUF2442 domain-containing protein	Antitoxin
A1552VC_RS16910	432537..432662	+	126	WP_001905700.1	DUF645 family protein	-
A1552VC_RS16920	432913..433308	+	396	WP_001000867.1	hypothetical protein	-
A1552VC_RS16925	433447..433725	-	279	WP_000578476.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
A1552VC_RS16930	433722..434006	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
A1552VC_RS16935	434200..434715	+	516	WP_000343779.1	GNAT family N-acetyltransferase	-
A1552VC_RS16945	434899..435312	+	414	WP_000049420.1	VOC family protein	-
A1552VC_RS16960	435867..437044	+	1178	WP_086010879.1	IS3-like element ISVch4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	306914..436175	129261
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0	inside	Integron	-	-	311994..435799	123805
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000179, TA000177, TA000178, TA010035 428335..428772 0	flank	IS/Tn	-	-	428747..429184	437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Protein of unknown function DUF2442 (4-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T104351 WP_001114075.1 NZ_CP028895:431454-431723 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T104351 NZ_CP028895:431454-431723 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19409.01 Da
• Isoelectric Point: 6.7342

>AT104351 WP_000921691.1 NZ_CP028895:431717-432238 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

>AT104351 NZ_CP028895:431717-432238 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Structures

Toxin

• AlphaFold DB: A0A086SLD6

Antitoxin

• AlphaFold DB: Q9KM84