180876

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 486701..487229 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag IT766_RS16275 Protein ID WP_000221354.1
Coordinates 486942..487229 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag IT766_RS16270 Protein ID WP_001250179.1
Coordinates 486701..486952 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT766_RS16225 481969..482283 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
IT766_RS16230 482420..482854 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
IT766_RS16235 483022..483177 + 156 WP_000751734.1 hypothetical protein -
IT766_RS16240 483302..484282 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
IT766_RS16245 484350..484622 + 273 Protein_499 CatB-related O-acetyltransferase -
IT766_RS16250 484793..485485 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
IT766_RS16255 485485..485886 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
IT766_RS16260 485856..485999 + 144 WP_071908341.1 DUF3265 domain-containing protein -
IT766_RS16265 486074..486487 + 414 WP_000049417.1 VOC family protein -
IT766_RS16270 486701..486952 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IT766_RS16275 486942..487229 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IT766_RS16280 487357..487812 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
IT766_RS16285 488134..488286 + 153 WP_001884520.1 DUF645 family protein -
IT766_RS16290 488488..488985 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
IT766_RS16295 488982..489254 - 273 WP_000246253.1 DUF1778 domain-containing protein -
IT766_RS16300 489485..490153 + 669 WP_000043871.1 hypothetical protein -
IT766_RS16305 490305..490592 + 288 WP_000426470.1 hypothetical protein -
IT766_RS16310 490733..491104 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
IT766_RS16315 491171..491596 + 426 WP_001882332.1 DUF1778 domain-containing protein -
IT766_RS16320 491593..492126 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 373204..502464 129260
inside Integron - - 378284..502088 123804
flank IS/Tn - - 483302..484282 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T180876 WP_000221354.1 NZ_CP064351:486942-487229 [Vibrio cholerae C6706]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T180876 NZ_CP085767:2939556-2939924 [Enterobacter hormaechei]
ATGAAAACTTTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGTCTCCAGTGGCTGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATCAAACCGTTATACAGGAACATATCG
ATGCGGGTATCACTCTGGCTAATGCCGTTAACTTTCTGGTAGAAAAGTATGAGTTAGTACGTATCGATCGCACAGGATTT
ACCTCACAGGAACAAGCGCCATATTTGACCGTGACAGATATCCTTCATGCCAGGAGAGCATGCGGATTAATGAACAGTTG
TTCGTATCGGGAAGTAAGTAATATTGTTCTTAGCCGATCGCGGCAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT180876 WP_001250179.1 NZ_CP064351:486701-486952 [Vibrio cholerae C6706]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT180876 NZ_CP085767:2939215-2939535 [Enterobacter hormaechei]
ATGAGGAGTAACGCTACATGGGGACTGCAACGTGATATCACACCGCGTCTGGGAGCCCGTCTGGTGCAGGAGGGCAACCG
GCTCCACTATCTGGCTGACCGGGCAAGTATCACCGGTAAATTCAGTGACGCCGAATGCCTGAAGTTGGATGTCGCATTCC
CGCATTTTATCAGTCTGATGGAATCAATGCTGACTACTGGTGAAATGAACCCTCGCCATGCCCACTGTGTCACCCTGTAC
CGCAACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGCTGCGGCTACTTATATATCGTTGTTTATCCCACTCAAAGCTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References