Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | DhiAT/- |
Location | 839580..840364 | Replicon | chromosome |
Accession | NZ_CP090400 | ||
Organism | Vibrio cholerae strain PanChol |
Toxin (Protein)
Gene name | dhiT | Uniprot ID | A0A086SLD6 |
Locus tag | LZM82_RS17245 | Protein ID | WP_001114075.1 |
Coordinates | 840095..840364 (-) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | dhiA | Uniprot ID | Q9KM84 |
Locus tag | LZM82_RS17240 | Protein ID | WP_000921691.1 |
Coordinates | 839580..840101 (-) | Length | 174 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LZM82_RS17210 (LZM82_17210) | 836506..836919 | - | 414 | WP_000049420.1 | VOC family protein | - |
LZM82_RS17215 (LZM82_17215) | 837103..837618 | - | 516 | WP_000343779.1 | GNAT family protein | - |
LZM82_RS17220 (LZM82_17220) | 837812..838096 | + | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
LZM82_RS17225 (LZM82_17225) | 838093..838371 | + | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
LZM82_RS17230 (LZM82_17230) | 838510..838905 | - | 396 | WP_001000867.1 | hypothetical protein | - |
LZM82_RS17235 (LZM82_17235) | 839156..839281 | - | 126 | WP_001905700.1 | DUF645 family protein | - |
LZM82_RS17240 (LZM82_17240) | 839580..840101 | - | 522 | WP_000921691.1 | DUF2442 domain-containing protein | Antitoxin |
LZM82_RS17245 (LZM82_17245) | 840095..840364 | - | 270 | WP_001114075.1 | DUF4160 domain-containing protein | Toxin |
LZM82_RS17250 (LZM82_17250) | 840431..840499 | - | 69 | Protein_717 | acetyltransferase | - |
LZM82_RS17255 (LZM82_17255) | 840556..841155 | - | 600 | WP_001891245.1 | glutathione S-transferase N-terminal domain-containing protein | - |
LZM82_RS17260 (LZM82_17260) | 841305..842177 | - | 873 | WP_000254716.1 | DUF3800 domain-containing protein | - |
LZM82_RS17265 (LZM82_17265) | 842352..842573 | - | 222 | Protein_720 | GNAT family N-acetyltransferase | - |
LZM82_RS17270 (LZM82_17270) | 842634..843071 | - | 438 | WP_000503164.1 | IS200/IS605-like element IS1004 family transposase | - |
LZM82_RS17275 (LZM82_17275) | 843190..843399 | - | 210 | Protein_722 | GNAT family N-acetyltransferase | - |
LZM82_RS17280 (LZM82_17280) | 843535..843924 | - | 390 | WP_001081302.1 | hypothetical protein | - |
LZM82_RS17285 (LZM82_17285) | 844081..844998 | - | 918 | WP_000186333.1 | alpha/beta hydrolase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 835643..943910 | 108267 | |
inside | Integron | - | - | 836019..937068 | 101049 | ||
flank | IS/Tn | - | - | 842634..843071 | 437 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10310.94 Da Isoelectric Point: 6.6303
>T230636 WP_001114075.1 NZ_CP090400:c840364-840095 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
Download Length: 270 bp
>T230636 NZ_CP125220:c4031597-4031289 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
Antitoxin
Download Length: 174 a.a. Molecular weight: 19409.01 Da Isoelectric Point: 6.7342
>AT230636 WP_000921691.1 NZ_CP090400:c840101-839580 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI
Download Length: 522 bp
>AT230636 NZ_CP125220:c4031839-4031600 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A086SLD6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q9KM84 |