230636

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) DhiAT/-
Location 839580..840364 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag LZM82_RS17245 Protein ID WP_001114075.1
Coordinates 840095..840364 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag LZM82_RS17240 Protein ID WP_000921691.1
Coordinates 839580..840101 (-) Length 174 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZM82_RS17210 (LZM82_17210) 836506..836919 - 414 WP_000049420.1 VOC family protein -
LZM82_RS17215 (LZM82_17215) 837103..837618 - 516 WP_000343779.1 GNAT family protein -
LZM82_RS17220 (LZM82_17220) 837812..838096 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LZM82_RS17225 (LZM82_17225) 838093..838371 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
LZM82_RS17230 (LZM82_17230) 838510..838905 - 396 WP_001000867.1 hypothetical protein -
LZM82_RS17235 (LZM82_17235) 839156..839281 - 126 WP_001905700.1 DUF645 family protein -
LZM82_RS17240 (LZM82_17240) 839580..840101 - 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
LZM82_RS17245 (LZM82_17245) 840095..840364 - 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
LZM82_RS17250 (LZM82_17250) 840431..840499 - 69 Protein_717 acetyltransferase -
LZM82_RS17255 (LZM82_17255) 840556..841155 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
LZM82_RS17260 (LZM82_17260) 841305..842177 - 873 WP_000254716.1 DUF3800 domain-containing protein -
LZM82_RS17265 (LZM82_17265) 842352..842573 - 222 Protein_720 GNAT family N-acetyltransferase -
LZM82_RS17270 (LZM82_17270) 842634..843071 - 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
LZM82_RS17275 (LZM82_17275) 843190..843399 - 210 Protein_722 GNAT family N-acetyltransferase -
LZM82_RS17280 (LZM82_17280) 843535..843924 - 390 WP_001081302.1 hypothetical protein -
LZM82_RS17285 (LZM82_17285) 844081..844998 - 918 WP_000186333.1 alpha/beta hydrolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 835643..943910 108267
inside Integron - - 836019..937068 101049
flank IS/Tn - - 842634..843071 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-74)

Antitoxin

(4-59)


Sequences


Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T230636 WP_001114075.1 NZ_CP090400:c840364-840095 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T230636 NZ_CP125220:c4031597-4031289 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT230636 WP_000921691.1 NZ_CP090400:c840101-839580 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT230636 NZ_CP125220:c4031839-4031600 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A086SLD6


Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References