Detailed information of TA system TA145851

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 391192..391829
• Replicon: chromosome
• Accession: NZ_CP047300
• Organism: Vibrio cholerae O1 biovar El Tor strain P27459

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GTF71_RS15460
• Protein ID: WP_000869997.1
• Coordinates: 391470..391829 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D0IIK3
• Locus tag: GTF71_RS15455
• Protein ID: WP_000086649.1
• Coordinates: 391192..391473 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GTF71_RS15420	386314..386673	+	360	WP_001071514.1	VOC family protein	-
GTF71_RS15425	386856..387179	+	324	WP_001889156.1	DUF3709 domain-containing protein	-
GTF71_RS15430	387460..387996	+	537	WP_000469482.1	GNAT family N-acetyltransferase	-
GTF71_RS15435	388757..388939	+	183	WP_000947517.1	DUF645 family protein	-
GTF71_RS15440	389058..389843	+	786	WP_001176447.1	hypothetical protein	-
GTF71_RS15445	389945..390307	+	363	WP_170831679.1	DUF4144 domain-containing protein	-
GTF71_RS15450	390553..390978	+	426	WP_000735184.1	hypothetical protein	-
GTF71_RS15455	391192..391473	+	282	WP_000086649.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GTF71_RS15460	391470..391829	+	360	WP_000869997.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GTF71_RS15465	391934..392257	+	324	WP_001999495.1	DUF3709 domain-containing protein	-
GTF71_RS15470	392543..392938	+	396	WP_000870868.1	DUF3465 domain-containing protein	-
GTF71_RS15475	393005..393119	+	115	Protein_405	acetyltransferase	-
GTF71_RS15480	393128..393349	+	222	WP_043987927.1	DUF1289 domain-containing protein	-
GTF71_RS15485	393325..393483	-	159	WP_001909351.1	DUF1196 family protein	-
GTF71_RS15490	393713..394138	+	426	WP_000415748.1	hypothetical protein	-
GTF71_RS15495	394464..394697	+	234	WP_001999499.1	DUF3709 domain-containing protein	-
GTF71_RS15500	394886..395281	+	396	WP_001889207.1	DUF4144 domain-containing protein	-
GTF71_RS15505	395500..395889	+	390	WP_000491261.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	306926..439292	132366
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0	inside	Integron	-	-	312006..438916	126910

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13608.84 Da
• Isoelectric Point: 8.1459

>T145851 WP_000869997.1 NZ_CP047300:391470-391829 [Vibrio cholerae O1 biovar El Tor]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTLRQEQTVNPPHNKRLKRDCQRVAFPVPLSRGGCSCCV

Nucleotide

• Length: 360 bp

>T145851 NZ_CP062702:4155874-4156092 [Escherichia coli O157:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10361.93 Da
• Isoelectric Point: 5.1548

>AT145851 WP_000086649.1 NZ_CP047300:391192-391473 [Vibrio cholerae O1 biovar El Tor]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Nucleotide

• Length: 282 bp

>AT145851 NZ_CP062702:4155474-4155848 [Escherichia coli O157:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A0K9UIW4