Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 418478..419111 Replicon chromosome
Accession NZ_CP047300
Organism Vibrio cholerae O1 biovar El Tor strain P27459

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag GTF71_RS15700 Protein ID WP_000843587.1
Coordinates 418478..418810 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GTF71_RS15705 Protein ID WP_000071008.1
Coordinates 418797..419111 (+) Length 105 a.a.

Genomic Context

GTF71_RS15635GTF71_RS15640GTF71_RS15645GTF71_RS15650GTF71_RS15655GTF71_RS15660GTF71_RS15665GTF71_RS15670GTF71_RS15675GTF71_RS15685GTF71_RS15690GTF71_RS15700GTF71_RS15705GTF71_RS15710GTF71_RS15715GTF71_RS15725GTF71_RS15730GTF71_RS15735GTF71_RS15740GTF71_RS15745GTF71_RS15750GTF71_RS15755GTF71_RS15680GTF71_RS15695GTF71_RS15720
Location: 413919..414122 (204 bp)
Type: Others
Protein ID: WP_001911745.1
Location: 414403..414576 (174 bp)
Type: Others
Protein ID: WP_001882305.1
Location: 414936..415205 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 415516..415602 (87 bp)
Type: Others
Protein ID: WP_134820423.1
Location: 415602..415694 (93 bp)
Type: Others
Protein ID: Protein_441
Location: 415903..416289 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 416491..416733 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 416904..417281 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 417461..417682 (222 bp)
Type: Others
Protein ID: WP_032468461.1
Location: 417848..417961 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 417910..418137 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 418478..418810 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 418797..419111 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 419248..419682 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 419850..420005 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 421178..421450 (273 bp)
Type: Others
Protein ID: Protein_455
Location: 421621..422313 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 422313..422714 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 422684..422827 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 422902..423315 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 423529..423780 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 423770..424057 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 417658..417816 (159 bp)
Type: Others
Protein ID: WP_001894455.1
Location: 418167..418325 (159 bp)
Type: Others
Protein ID: WP_001882309.1
Location: 420130..421110 (981 bp)
Type: Others
Protein ID: WP_000019370.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF71_RS15635413919..414122+204WP_001911745.1hypothetical protein-
GTF71_RS15640414403..414576+174WP_001882305.1DUF3709 domain-containing protein-
GTF71_RS15645414936..415205+270WP_001198131.1hypothetical protein-
GTF71_RS15650415516..415602+87WP_134820423.1DUF645 family protein-
GTF71_RS15655415602..415694+93Protein_441DUF645 family protein-
GTF71_RS15660415903..416289+387WP_000703163.1VOC family protein-
GTF71_RS15665416491..416733+243WP_000107461.1hypothetical protein-
GTF71_RS15670416904..417281+378WP_000411109.1hypothetical protein-
GTF71_RS15675417461..417682+222WP_032468461.1DUF1289 domain-containing protein-
GTF71_RS15680417658..417816-159WP_001894455.1DUF1196 family protein-
GTF71_RS15685417848..417961+114WP_001889158.1hypothetical protein-
GTF71_RS15690417910..418137+228WP_001894457.1DUF1289 domain-containing protein-
GTF71_RS15695418167..418325-159WP_001882309.1DUF1196 family protein-
GTF71_RS15700418478..418810+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF71_RS15705418797..419111+315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
GTF71_RS15710419248..419682+435WP_000256036.1GNAT family N-acetyltransferase-
GTF71_RS15715419850..420005+156WP_000751734.1hypothetical protein-
GTF71_RS15720420130..421110-981WP_000019370.1IS5-like element ISVch5 family transposase-
GTF71_RS15725421178..421450+273Protein_455CatB-related O-acetyltransferase-
GTF71_RS15730421621..422313+693WP_001047169.1GNAT family N-acetyltransferase-
GTF71_RS15735422313..422714+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
GTF71_RS15740422684..422827+144WP_071908341.1DUF3265 domain-containing protein-
GTF71_RS15745422902..423315+414WP_000049417.1VOC family protein-
GTF71_RS15750423529..423780+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF71_RS15755423770..424057+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306926..439292132366
insideIntegron--312006..438916126910
flankIS/Tn--420130..421110980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T145853 WP_000843587.1 NZ_CP047300:418478-418810 [Vibrio cholerae O1 biovar El Tor]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T145853 NZ_CP062702:4415541-4415801 [Escherichia coli O157:H7]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT145853 WP_000071008.1 NZ_CP047300:418797-419111 [Vibrio cholerae O1 biovar El Tor]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT145853 NZ_CP062702:4415262-4415522 [Escherichia coli O157:H7]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

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Source
ID
Structure
No matching records found

References