Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 368082..368697 Replicon chromosome
Accession NZ_CP009041
Organism Vibrio cholerae O1 biovar El Tor strain FJ147

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag IR04_RS01795 Protein ID WP_001162670.1
Coordinates 368082..368369 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IR04_RS01800 Protein ID WP_001232701.1
Coordinates 368380..368697 (+) Length 106 a.a.

Genomic Context

IR04_RS20395IR04_RS01775IR04_RS01780IR04_RS01785IR04_RS19310IR04_RS01790IR04_RS01795IR04_RS01800IR04_RS20400IR04_RS20405IR04_RS20410IR04_RS01805IR04_RS01810IR04_RS01815IR04_RS19990IR04_RS01820IR04_RS01825IR04_RS01765IR04_RS01770
Location: 363718..363813 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 364827..365336 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 365393..366046 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 366356..366574 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 366977..367210 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 367635..367815 (181 bp)
Type: Others
Protein ID: Protein_361
Location: 368082..368369 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 368380..368697 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 368694..368804 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 368981..369106 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 369122..369160 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 369373..370377 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 370530..370976 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 371096..372025 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 372022..372132 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 372160..372636 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 372773..373288 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 364007..364324 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 364343..364585 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IR04_RS20395363718..363813+96WP_001907607.1DUF645 family protein-
IR04_RS01765364007..364324-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
IR04_RS01770364343..364585-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
IR04_RS01775364827..365336+510WP_000405987.1GNAT family N-acetyltransferase-
IR04_RS01780365393..366046+654WP_000226874.1hypothetical protein-
IR04_RS01785366356..366574+219WP_001917086.1DUF3709 domain-containing protein-
IR04_RS19310366977..367210+234WP_032482776.1DUF3709 domain-containing protein-
IR04_RS01790367635..367815+181Protein_361DUF645 family protein-
IR04_RS01795368082..368369+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
IR04_RS01800368380..368697+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
IR04_RS20400368694..368804+111WP_134814058.1DUF3265 domain-containing protein-
IR04_RS20405368981..369106+126WP_001944767.1DUF645 family protein-
IR04_RS20410369122..369160+39WP_106019119.1hypothetical protein-
IR04_RS01805369373..370377+1005WP_000964925.1LD-carboxypeptidase-
IR04_RS01810370530..370976+447WP_000128977.1hypothetical protein-
IR04_RS01815371096..372025+930WP_000335802.1hypothetical protein-
IR04_RS19990372022..372132+111WP_071917832.1DUF3265 domain-containing protein-
IR04_RS01820372160..372636+477WP_001047180.1GNAT family N-acetyltransferase-
IR04_RS01825372773..373288+516WP_001201528.1lipocalin family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..409892105192
insideIntegron--309780..40951699736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T48152 WP_001162670.1 NZ_CP009041:368082-368369 [Vibrio cholerae O1 biovar El Tor]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T48152 NZ_CP009041:368082-368369 [Vibrio cholerae O1 biovar El Tor]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT48152 WP_001232701.1 NZ_CP009041:368380-368697 [Vibrio cholerae O1 biovar El Tor]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT48152 NZ_CP009041:368380-368697 [Vibrio cholerae O1 biovar El Tor]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References