145403

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 395396..395924 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag GQX72_RS15900 Protein ID WP_000221354.1
Coordinates 395637..395924 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag GQX72_RS15895 Protein ID WP_001250179.1
Coordinates 395396..395647 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX72_RS15850 390664..390978 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
GQX72_RS15855 391115..391549 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
GQX72_RS15860 391717..391872 + 156 WP_000751734.1 hypothetical protein -
GQX72_RS15865 391997..392977 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
GQX72_RS15870 393045..393351 + 307 Protein_404 CatB-related O-acetyltransferase -
GQX72_RS15875 393488..394180 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
GQX72_RS15880 394180..394581 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GQX72_RS15885 394551..394694 + 144 WP_071908341.1 DUF3265 domain-containing protein -
GQX72_RS15890 394769..395182 + 414 WP_000049417.1 VOC family protein -
GQX72_RS15895 395396..395647 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GQX72_RS15900 395637..395924 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQX72_RS15905 396052..396507 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
GQX72_RS15910 396829..396981 + 153 WP_001884520.1 DUF645 family protein -
GQX72_RS15920 397183..397680 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GQX72_RS15925 397677..397949 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GQX72_RS15930 398180..398848 + 669 WP_000043871.1 hypothetical protein -
GQX72_RS15935 399000..399287 + 288 WP_000426470.1 hypothetical protein -
GQX72_RS15940 399428..399799 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GQX72_RS19055 399866..400291 + 426 WP_001882332.1 DUF1778 domain-containing protein -
GQX72_RS15950 400288..400821 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305960..411159 105199
inside Integron - - 311040..410783 99743
flank IS/Tn - - 391997..392977 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T145403 WP_000221354.1 NZ_CP047060:395637-395924 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T145403 NZ_CP062376:2303054-2303161 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT145403 WP_001250179.1 NZ_CP047060:395396-395647 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT145403 NZ_CP062376:c2303238-2303178 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References