230645

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 880950..881528 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag LZM82_RS17675 Protein ID WP_001180243.1
Coordinates 881211..881528 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag LZM82_RS17670 Protein ID WP_000557292.1
Coordinates 880950..881192 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZM82_RS17600 (LZM82_17600) 876350..876466 - 117 WP_001889170.1 hypothetical protein -
LZM82_RS17605 (LZM82_17605) 876429..876554 - 126 WP_001944767.1 DUF645 family protein -
LZM82_RS17610 (LZM82_17610) 876582..876692 - 111 Protein_790 acetyltransferase -
LZM82_RS17615 (LZM82_17615) 876731..876841 - 111 WP_134814058.1 DUF3265 domain-containing protein -
LZM82_RS17620 (LZM82_17620) 876838..877155 - 318 WP_001232701.1 HigA family addiction module antitoxin -
LZM82_RS17625 (LZM82_17625) 877166..877453 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZM82_RS17630 (LZM82_17630) 877494..877607 - 114 WP_001894955.1 hypothetical protein -
LZM82_RS17635 (LZM82_17635) 877720..877900 - 181 Protein_795 DUF645 family protein -
LZM82_RS17640 (LZM82_17640) 878325..878558 - 234 WP_032482776.1 DUF3709 domain-containing protein -
LZM82_RS17645 (LZM82_17645) 878579..878772 - 194 Protein_797 hypothetical protein -
LZM82_RS17650 (LZM82_17650) 878961..879179 - 219 WP_001917086.1 DUF3709 domain-containing protein -
LZM82_RS17655 (LZM82_17655) 879191..879400 - 210 WP_001900246.1 DUF3709 domain-containing protein -
LZM82_RS17660 (LZM82_17660) 879489..880142 - 654 WP_000226874.1 hypothetical protein -
LZM82_RS17665 (LZM82_17665) 880199..880708 - 510 WP_000405987.1 GNAT family N-acetyltransferase -
LZM82_RS17670 (LZM82_17670) 880950..881192 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LZM82_RS17675 (LZM82_17675) 881211..881528 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZM82_RS17680 (LZM82_17680) 881722..881874 - 153 Protein_804 DUF645 family protein -
LZM82_RS17685 (LZM82_17685) 881935..882110 - 176 Protein_805 acetyltransferase -
LZM82_RS17690 (LZM82_17690) 882173..882466 - 294 WP_125460920.1 hypothetical protein -
LZM82_RS17695 (LZM82_17695) 882613..882960 - 348 WP_000933409.1 hypothetical protein -
LZM82_RS17700 (LZM82_17700) 883109..883534 - 426 WP_000403014.1 GNAT family N-acetyltransferase -
LZM82_RS17705 (LZM82_17705) 883693..883803 - 111 WP_223804330.1 Tfp pilus assembly protein -
LZM82_RS17710 (LZM82_17710) 883793..883855 - 63 Protein_810 DUF645 family protein -
LZM82_RS17715 (LZM82_17715) 884206..884742 - 537 WP_000644491.1 nucleotidyltransferase family protein -
LZM82_RS17720 (LZM82_17720) 884886..885242 - 357 WP_001094970.1 DUF6404 family protein -
LZM82_RS17725 (LZM82_17725) 885458..885577 - 120 WP_001900954.1 DUF645 family protein -
LZM82_RS17730 (LZM82_17730) 885700..885843 - 144 Protein_814 acetyltransferase -
LZM82_RS17735 (LZM82_17735) 885942..886298 - 357 WP_001094969.1 DUF6404 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 835643..943910 108267
inside Integron - - 836019..937068 101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T230645 WP_001180243.1 NZ_CP090400:881211-881528 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T230645 NZ_CP125224:5666-5953 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGATATACTAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT230645 WP_000557292.1 NZ_CP090400:880950-881192 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT230645 NZ_CP125224:5940-6254 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References