Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1015360..1015900 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag K1T75_RS18495 Protein ID WP_000277238.1
Coordinates 1015631..1015900 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag K1T75_RS18490 Protein ID WP_001258569.1
Coordinates 1015360..1015638 (+) Length 93 a.a.

Genomic Context

K1T75_RS18490K1T75_RS18495K1T75_RS18515K1T75_RS18520K1T75_RS18550K1T75_RS18440K1T75_RS18980K1T75_RS18455K1T75_RS18460K1T75_RS18985K1T75_RS18465K1T75_RS18470K1T75_RS18475K1T75_RS18990K1T75_RS18485K1T75_RS18995K1T75_RS18500K1T75_RS18510K1T75_RS19000K1T75_RS18525K1T75_RS18530K1T75_RS18535K1T75_RS18540K1T75_RS18545
Location: 1015360..1015638 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
Location: 1015631..1015900 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 1017262..1017534 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 1017531..1018028 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 1020654..1020896 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 1010940..1011407 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 1011579..1011710 (132 bp)
Type: Others
Protein ID: WP_001883067.1
Location: 1012229..1012507 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 1012759..1013001 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 1013093..1013242 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 1013215..1013466 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 1013661..1014047 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 1014037..1014138 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 1014338..1014436 (99 bp)
Type: Others
Protein ID: WP_223225486.1
Location: 1014796..1015074 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 1015192..1015309 (118 bp)
Type: Others
Protein ID: Protein_963
Location: 1016048..1016494 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 1016744..1016869 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 1018045..1018113 (69 bp)
Type: Others
Protein ID: Protein_970
Location: 1018178..1018639 (462 bp)
Type: Others
Protein ID: WP_001903091.1
Location: 1018830..1019366 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 1019624..1019845 (222 bp)
Type: Others
Protein ID: WP_032467793.1
Location: 1019854..1019967 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 1020024..1020410 (387 bp)
Type: Others
Protein ID: WP_001015867.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K1T75_RS184401010940..1011407-468WP_001289288.1OsmC family protein-
K1T75_RS189801011579..1011710-132WP_001883067.1hypothetical protein-
K1T75_RS184551012229..1012507-279WP_000280324.1DUF3709 domain-containing protein-
K1T75_RS184601012759..1013001-243WP_000107461.1hypothetical protein-
K1T75_RS189851013093..1013242-150WP_071908333.1DUF3265 domain-containing protein-
K1T75_RS184651013215..1013466-252WP_001890111.1TIGR03643 family protein-
K1T75_RS184701013661..1014047-387WP_000703163.1VOC family protein-
K1T75_RS184751014037..1014138-102WP_001921603.1hypothetical protein-
K1T75_RS189901014338..1014436-99WP_223225486.1DUF3709 domain-containing protein-
K1T75_RS184851014796..1015074-279WP_001921601.1DUF3709 domain-containing protein-
K1T75_RS189951015192..1015309-118Protein_963DUF3265 domain-containing protein-
K1T75_RS184901015360..1015638+279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
K1T75_RS184951015631..1015900+270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
K1T75_RS185001016048..1016494-447WP_000006157.1hypothetical protein-
K1T75_RS185101016744..1016869-126WP_001900195.1DUF645 family protein-
K1T75_RS185151017262..1017534+273WP_000246253.1DUF1778 domain-containing protein-
K1T75_RS185201017531..1018028+498WP_000982260.1GNAT family N-acetyltransferase-
K1T75_RS190001018045..1018113-69Protein_970acetyltransferase-
K1T75_RS185251018178..1018639-462WP_001903091.1lipocalin family protein-
K1T75_RS185301018830..1019366-537WP_000469482.1GNAT family protein-
K1T75_RS185351019624..1019845-222WP_032467793.1DUF1289 domain-containing protein-
K1T75_RS185401019854..1019967-114WP_001900214.1hypothetical protein-
K1T75_RS185451020024..1020410-387WP_001015867.1NUDIX hydrolase-
K1T75_RS185501020654..1020896+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932680..1039634106954
insideIntegron--933056..103279299736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T211920 WP_000277238.1 NZ_CP080466:1015631-1015900 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T211920 NZ_CP106849:1963258-1963635 [Edwardsiella ictaluri]
ATGGGCAAGAACTTGCGAAAACATAACAATATTGTTATGTTTCACTCCATGAACTACACTATTGAGTACTACAGCGAAGA
GGTTCGGCTTGAGGTCGATCAGTTGCCAATGGGTATGCGGGTTCGATACCAGCATCTCGTTGAACGCATGGAAATCTACG
GTAGTAATCTCGGAGAACCACACACAAGCCCTTTTGGCGATGGGCTTTTTGAGCTTCGAATCAAAGGCAGTGATGGCATC
GCCCGCGTGTTTTACTGCACTCTTACCGGAAAACGTATCGTCATGCTGCACAGCTTCATCAAGAAAACCCAGAAGACGCC
AAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAACATGGCTGGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT211920 WP_001258569.1 NZ_CP080466:1015360-1015638 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT211920 NZ_CP106849:1963625-1963933 [Edwardsiella ictaluri]
ATGGCTGGTAAACGCACCCCCCCCACGATGACGCATGATGAAATGGCTGCAAAATGGATGGAAGACCCGGCATTTAAAGC
AGAATACGATGCCATCGAAGAGGAATACGCCCTACTCGATGAAATGCTCGCAGCCCGCAAAAACGCGGGGCTGACCCAGG
CGCAGGTCGCCGAACGTATGGGAACCAAGGCTACAGCGATCACTCGCATGGAAAGTAATTTAGCCTCCGGCCAAAGCGGG
CCATCATTCGCCACGCTGAAAAAATTTGCACACGCGACCGGCAAGAAACTGCAGATCCGGTTTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References