211920

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1015360..1015900 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag K1T75_RS18495 Protein ID WP_000277238.1
Coordinates 1015631..1015900 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag K1T75_RS18490 Protein ID WP_001258569.1
Coordinates 1015360..1015638 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T75_RS18440 1010940..1011407 - 468 WP_001289288.1 OsmC family protein -
K1T75_RS18980 1011579..1011710 - 132 WP_001883067.1 hypothetical protein -
K1T75_RS18455 1012229..1012507 - 279 WP_000280324.1 DUF3709 domain-containing protein -
K1T75_RS18460 1012759..1013001 - 243 WP_000107461.1 hypothetical protein -
K1T75_RS18985 1013093..1013242 - 150 WP_071908333.1 DUF3265 domain-containing protein -
K1T75_RS18465 1013215..1013466 - 252 WP_001890111.1 TIGR03643 family protein -
K1T75_RS18470 1013661..1014047 - 387 WP_000703163.1 VOC family protein -
K1T75_RS18475 1014037..1014138 - 102 WP_001921603.1 hypothetical protein -
K1T75_RS18990 1014338..1014436 - 99 WP_223225486.1 DUF3709 domain-containing protein -
K1T75_RS18485 1014796..1015074 - 279 WP_001921601.1 DUF3709 domain-containing protein -
K1T75_RS18995 1015192..1015309 - 118 Protein_963 DUF3265 domain-containing protein -
K1T75_RS18490 1015360..1015638 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K1T75_RS18495 1015631..1015900 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
K1T75_RS18500 1016048..1016494 - 447 WP_000006157.1 hypothetical protein -
K1T75_RS18510 1016744..1016869 - 126 WP_001900195.1 DUF645 family protein -
K1T75_RS18515 1017262..1017534 + 273 WP_000246253.1 DUF1778 domain-containing protein -
K1T75_RS18520 1017531..1018028 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
K1T75_RS19000 1018045..1018113 - 69 Protein_970 acetyltransferase -
K1T75_RS18525 1018178..1018639 - 462 WP_001903091.1 lipocalin family protein -
K1T75_RS18530 1018830..1019366 - 537 WP_000469482.1 GNAT family protein -
K1T75_RS18535 1019624..1019845 - 222 WP_032467793.1 DUF1289 domain-containing protein -
K1T75_RS18540 1019854..1019967 - 114 WP_001900214.1 hypothetical protein -
K1T75_RS18545 1020024..1020410 - 387 WP_001015867.1 NUDIX hydrolase -
K1T75_RS18550 1020654..1020896 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932680..1039634 106954
inside Integron - - 933056..1032792 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T211920 WP_000277238.1 NZ_CP080466:1015631-1015900 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T211920 NZ_CP106849:1963258-1963635 [Edwardsiella ictaluri]
ATGGGCAAGAACTTGCGAAAACATAACAATATTGTTATGTTTCACTCCATGAACTACACTATTGAGTACTACAGCGAAGA
GGTTCGGCTTGAGGTCGATCAGTTGCCAATGGGTATGCGGGTTCGATACCAGCATCTCGTTGAACGCATGGAAATCTACG
GTAGTAATCTCGGAGAACCACACACAAGCCCTTTTGGCGATGGGCTTTTTGAGCTTCGAATCAAAGGCAGTGATGGCATC
GCCCGCGTGTTTTACTGCACTCTTACCGGAAAACGTATCGTCATGCTGCACAGCTTCATCAAGAAAACCCAGAAGACGCC
AAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAACATGGCTGGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT211920 WP_001258569.1 NZ_CP080466:1015360-1015638 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT211920 NZ_CP106849:1963625-1963933 [Edwardsiella ictaluri]
ATGGCTGGTAAACGCACCCCCCCCACGATGACGCATGATGAAATGGCTGCAAAATGGATGGAAGACCCGGCATTTAAAGC
AGAATACGATGCCATCGAAGAGGAATACGCCCTACTCGATGAAATGCTCGCAGCCCGCAAAAACGCGGGGCTGACCCAGG
CGCAGGTCGCCGAACGTATGGGAACCAAGGCTACAGCGATCACTCGCATGGAAAGTAATTTAGCCTCCGGCCAAAGCGGG
CCATCATTCGCCACGCTGAAAAAATTTGCACACGCGACCGGCAAGAAACTGCAGATCCGGTTTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References