Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 490250..491016 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ87_RS16760 Protein ID WP_000982260.1
Coordinates 490250..490747 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ87_RS16765 Protein ID WP_000246253.1
Coordinates 490744..491016 (-) Length 91 a.a.

Genomic Context

ASZ87_RS16710ASZ87_RS16715ASZ87_RS16730ASZ87_RS16735ASZ87_RS16740ASZ87_RS16750ASZ87_RS16755ASZ87_RS20635ASZ87_RS20640ASZ87_RS16775ASZ87_RS16790ASZ87_RS20655ASZ87_RS20660ASZ87_RS16795ASZ87_RS16800ASZ87_RS16805ASZ87_RS16810ASZ87_RS16720ASZ87_RS16725ASZ87_RS16760ASZ87_RS16765ASZ87_RS16780ASZ87_RS16785
Location: 485692..486396 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 486554..486892 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 487868..488254 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 488311..488424 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 488373..488654 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 488912..489448 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 489585..490100 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 491409..491534 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 491550..491588 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 491784..492230 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 493204..493482 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 493734..493940 (207 bp)
Type: Others
Protein ID: Protein_463
Location: 494140..494241 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 494231..494617 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 494812..495063 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 495036..495185 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 495277..495519 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 487046..487363 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 487382..487624 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 490250..490747 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 490744..491016 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 492378..492647 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 492640..492918 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ87_RS16710485692..486396+705WP_000087610.1HNH endonuclease-
ASZ87_RS16715486554..486892+339WP_000713853.1hypothetical protein-
ASZ87_RS16720487046..487363-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ87_RS16725487382..487624-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ87_RS16730487868..488254+387WP_001015867.1NUDIX hydrolase-
ASZ87_RS16735488311..488424+114WP_001900214.1hypothetical protein-
ASZ87_RS16740488373..488654+282WP_001894429.1DUF1289 domain-containing protein-
ASZ87_RS16750488912..489448+537WP_000469482.1GNAT family N-acetyltransferase-
ASZ87_RS16755489585..490100+516WP_001201509.1lipocalin family protein-
ASZ87_RS16760490250..490747-498WP_000982260.1GNAT family N-acetyltransferaseToxin
ASZ87_RS16765490744..491016-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
ASZ87_RS20635491409..491534+126WP_001900195.1DUF645 family protein-
ASZ87_RS20640491550..491588+39WP_106019118.1hypothetical protein-
ASZ87_RS16775491784..492230+447WP_000006157.1hypothetical protein-
ASZ87_RS16780492378..492647-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
ASZ87_RS16785492640..492918-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
ASZ87_RS16790493204..493482+279WP_001921601.1DUF3709 domain-containing protein-
ASZ87_RS20655493734..493940+207Protein_463DUF3709 domain-containing protein-
ASZ87_RS20660494140..494241+102WP_001921603.1hypothetical protein-
ASZ87_RS16795494231..494617+387WP_000703163.1VOC family protein-
ASZ87_RS16800494812..495063+252WP_001890111.1TIGR03643 family protein-
ASZ87_RS16805495036..495185+150WP_071908333.1DUF3265 domain-containing protein-
ASZ87_RS16810495277..495519+243WP_000107461.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-435534..596659161125
insideIntegron--440614..596283155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58307 WP_000982260.1 NZ_CP013310:c490747-490250 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58307 NZ_CP013310:c490747-490250 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58307 WP_000246253.1 NZ_CP013310:c491016-490744 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58307 NZ_CP013310:c491016-490744 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References