58307

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 490250..491016 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ87_RS16760 Protein ID WP_000982260.1
Coordinates 490250..490747 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ87_RS16765 Protein ID WP_000246253.1
Coordinates 490744..491016 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ87_RS16710 485692..486396 + 705 WP_000087610.1 HNH endonuclease -
ASZ87_RS16715 486554..486892 + 339 WP_000713853.1 hypothetical protein -
ASZ87_RS16720 487046..487363 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ87_RS16725 487382..487624 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ87_RS16730 487868..488254 + 387 WP_001015867.1 NUDIX hydrolase -
ASZ87_RS16735 488311..488424 + 114 WP_001900214.1 hypothetical protein -
ASZ87_RS16740 488373..488654 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ87_RS16750 488912..489448 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ87_RS16755 489585..490100 + 516 WP_001201509.1 lipocalin family protein -
ASZ87_RS16760 490250..490747 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
ASZ87_RS16765 490744..491016 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
ASZ87_RS20635 491409..491534 + 126 WP_001900195.1 DUF645 family protein -
ASZ87_RS20640 491550..491588 + 39 WP_106019118.1 hypothetical protein -
ASZ87_RS16775 491784..492230 + 447 WP_000006157.1 hypothetical protein -
ASZ87_RS16780 492378..492647 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
ASZ87_RS16785 492640..492918 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ASZ87_RS16790 493204..493482 + 279 WP_001921601.1 DUF3709 domain-containing protein -
ASZ87_RS20655 493734..493940 + 207 Protein_463 DUF3709 domain-containing protein -
ASZ87_RS20660 494140..494241 + 102 WP_001921603.1 hypothetical protein -
ASZ87_RS16795 494231..494617 + 387 WP_000703163.1 VOC family protein -
ASZ87_RS16800 494812..495063 + 252 WP_001890111.1 TIGR03643 family protein -
ASZ87_RS16805 495036..495185 + 150 WP_071908333.1 DUF3265 domain-containing protein -
ASZ87_RS16810 495277..495519 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 435534..596659 161125
inside Integron - - 440614..596283 155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58307 WP_000982260.1 NZ_CP013310:c490747-490250 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58307 NZ_CP013310:c490747-490250 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58307 WP_000246253.1 NZ_CP013310:c491016-490744 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58307 NZ_CP013310:c491016-490744 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References