Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 232924..233557 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag K6J80_RS14970 Protein ID WP_000843587.1
Coordinates 233225..233557 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6J80_RS14965 Protein ID WP_000071008.1
Coordinates 232924..233238 (-) Length 105 a.a.

Genomic Context

K6J80_RS14950K6J80_RS14920K6J80_RS14925K6J80_RS14930K6J80_RS18960K6J80_RS14935K6J80_RS18965K6J80_RS18970K6J80_RS14945K6J80_RS14955K6J80_RS14960K6J80_RS14965K6J80_RS14970K6J80_RS14975K6J80_RS14980K6J80_RS14985K6J80_RS14990K6J80_RS14995K6J80_RS15000K6J80_RS15005K6J80_RS15010K6J80_RS18975K6J80_RS15015K6J80_RS15020K6J80_RS15025
Location: 230925..231905 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 227978..228265 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 228255..228506 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 228720..229133 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 229208..229318 (111 bp)
Type: Others
Protein ID: WP_082798255.1
Location: 229321..229722 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 229722..229892 (171 bp)
Type: Others
Protein ID: WP_001080654.1
Location: 230016..230414 (399 bp)
Type: Others
Protein ID: Protein_219
Location: 230551..230857 (307 bp)
Type: Others
Protein ID: Protein_220
Location: 232030..232185 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 232353..232787 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 232924..233238 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 233225..233557 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 233898..234125 (228 bp)
Type: Others
Protein ID: WP_073426587.1
Location: 234074..234187 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 234353..234574 (222 bp)
Type: Others
Protein ID: WP_032468461.1
Location: 234583..234697 (115 bp)
Type: Others
Protein ID: Protein_229
Location: 234754..235131 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 235302..235661 (360 bp)
Type: Others
Protein ID: WP_226979446.1
Location: 235746..236132 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 236341..236473 (133 bp)
Type: Others
Protein ID: Protein_233
Location: 236464..236589 (126 bp)
Type: Others
Protein ID: WP_080360924.1
Location: 236830..237099 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 237459..237656 (198 bp)
Type: Others
Protein ID: WP_001894451.1
Location: 237913..238116 (204 bp)
Type: Others
Protein ID: WP_001911745.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J80_RS14920227978..228265-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J80_RS14925228255..228506-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K6J80_RS14930228720..229133-414WP_000049417.1VOC family protein-
K6J80_RS18960229208..229318-111WP_082798255.1DUF3265 domain-containing protein-
K6J80_RS14935229321..229722-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
K6J80_RS18965229722..229892-171WP_001080654.1hypothetical protein-
K6J80_RS18970230016..230414-399Protein_219GNAT family N-acetyltransferase-
K6J80_RS14945230551..230857-307Protein_220CatB-related O-acetyltransferase-
K6J80_RS14950230925..231905+981WP_000019370.1IS5-like element ISVch5 family transposase-
K6J80_RS14955232030..232185-156WP_000751734.1hypothetical protein-
K6J80_RS14960232353..232787-435WP_000256036.1GNAT family N-acetyltransferase-
K6J80_RS14965232924..233238-315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
K6J80_RS14970233225..233557-333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K6J80_RS14975233898..234125-228WP_073426587.1DUF1289 domain-containing protein-
K6J80_RS14980234074..234187-114WP_001889158.1hypothetical protein-
K6J80_RS14985234353..234574-222WP_032468461.1DUF1289 domain-containing protein-
K6J80_RS14990234583..234697-115Protein_229acetyltransferase-
K6J80_RS14995234754..235131-378WP_000411109.1hypothetical protein-
K6J80_RS15000235302..235661-360WP_226979446.1pullulanase-
K6J80_RS15005235746..236132-387WP_000703163.1VOC family protein-
K6J80_RS15010236341..236473-133Protein_233DUF645 family protein-
K6J80_RS18975236464..236589-126WP_080360924.1general secretion pathway protein GspH-
K6J80_RS15015236830..237099-270WP_001198131.1hypothetical protein-
K6J80_RS15020237459..237656-198WP_001894451.1DUF3709 domain-containing protein-
K6J80_RS15025237913..238116-204WP_001911745.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-213119..319686106567
insideIntegron--213119..31285699737
flankIS/Tn--230925..231905980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T38675 WP_000843587.1 NZ_AP024554:c233557-233225 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T38675 NZ_AP024554:c233557-233225 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT38675 WP_000071008.1 NZ_AP024554:c233238-232924 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT38675 NZ_AP024554:c233238-232924 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

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Source
ID
Structure
No matching records found

References