145807

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 343643..344202 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GTF72_RS15370 Protein ID WP_000578476.1
Coordinates 343643..343921 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GTF72_RS15375 Protein ID WP_000381183.1
Coordinates 343918..344202 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF72_RS15320 338680..338913 + 234 WP_001890112.1 DUF3709 domain-containing protein -
GTF72_RS15325 339181..339687 + 507 WP_000393074.1 hypothetical protein -
GTF72_RS15330 339844..340230 + 387 WP_000703163.1 VOC family protein -
GTF72_RS15335 340425..340676 + 252 WP_001890111.1 TIGR03643 family protein -
GTF72_RS15340 340649..340798 + 150 WP_071908333.1 DUF3265 domain-containing protein -
GTF72_RS15345 340945..341370 + 426 WP_000415750.1 hypothetical protein -
GTF72_RS15350 341576..342199 + 624 WP_000247070.1 DUF1349 domain-containing protein -
GTF72_RS15355 342412..342891 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
GTF72_RS15360 343079..343492 + 414 WP_000049420.1 VOC family protein -
GTF72_RS15365 343499..343594 - 96 Protein_321 hypothetical protein -
GTF72_RS15370 343643..343921 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GTF72_RS15375 343918..344202 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GTF72_RS15380 344397..344912 + 516 WP_001201520.1 lipocalin family protein -
GTF72_RS15385 344977..345573 + 597 WP_000255434.1 hypothetical protein -
GTF72_RS15390 345965..346147 + 183 WP_000923182.1 DUF645 family protein -
GTF72_RS15395 346347..346820 + 474 WP_001161076.1 GrpB family protein -
GTF72_RS15400 346817..346927 + 111 WP_071908312.1 DUF3265 domain-containing protein -
GTF72_RS15405 346969..347595 + 627 WP_000365424.1 LysE family translocator -
GTF72_RS15410 347718..348416 + 699 WP_001890502.1 hypothetical protein -
GTF72_RS15415 348420..348536 + 117 WP_071908339.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306905..436165 129260
inside Integron - - 311985..435789 123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T145807 WP_000578476.1 NZ_CP047296:c343921-343643 [Vibrio cholerae C6706]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T145807 NZ_CP062700:c697207-696743 [Escherichia coli O157:H7]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT145807 WP_000381183.1 NZ_CP047296:c344202-343918 [Vibrio cholerae C6706]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT145807 NZ_CP062700:c697542-697207 [Escherichia coli O157:H7]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAGCAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References