Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 343643..344202 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GTF72_RS15370 Protein ID WP_000578476.1
Coordinates 343643..343921 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GTF72_RS15375 Protein ID WP_000381183.1
Coordinates 343918..344202 (-) Length 95 a.a.

Genomic Context

GTF72_RS15320GTF72_RS15325GTF72_RS15330GTF72_RS15335GTF72_RS15340GTF72_RS15345GTF72_RS15350GTF72_RS15355GTF72_RS15360GTF72_RS15380GTF72_RS15385GTF72_RS15390GTF72_RS15395GTF72_RS15400GTF72_RS15405GTF72_RS15410GTF72_RS15415GTF72_RS15365GTF72_RS15370GTF72_RS15375
Location: 338680..338913 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 339181..339687 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 339844..340230 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 340425..340676 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 340649..340798 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 340945..341370 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 341576..342199 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 342412..342891 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 343079..343492 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 344397..344912 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 344977..345573 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 345965..346147 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 346347..346820 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 346817..346927 (111 bp)
Type: Others
Protein ID: WP_071908312.1
Location: 346969..347595 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 347718..348416 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 348420..348536 (117 bp)
Type: Others
Protein ID: WP_071908339.1
Location: 343499..343594 (96 bp)
Type: Others
Protein ID: Protein_321
Location: 343643..343921 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 343918..344202 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF72_RS15320338680..338913+234WP_001890112.1DUF3709 domain-containing protein-
GTF72_RS15325339181..339687+507WP_000393074.1hypothetical protein-
GTF72_RS15330339844..340230+387WP_000703163.1VOC family protein-
GTF72_RS15335340425..340676+252WP_001890111.1TIGR03643 family protein-
GTF72_RS15340340649..340798+150WP_071908333.1DUF3265 domain-containing protein-
GTF72_RS15345340945..341370+426WP_000415750.1hypothetical protein-
GTF72_RS15350341576..342199+624WP_000247070.1DUF1349 domain-containing protein-
GTF72_RS15355342412..342891+480WP_000009888.1lecithin retinol acyltransferase family protein-
GTF72_RS15360343079..343492+414WP_000049420.1VOC family protein-
GTF72_RS15365343499..343594-96Protein_321hypothetical protein-
GTF72_RS15370343643..343921-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
GTF72_RS15375343918..344202-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
GTF72_RS15380344397..344912+516WP_001201520.1lipocalin family protein-
GTF72_RS15385344977..345573+597WP_000255434.1hypothetical protein-
GTF72_RS15390345965..346147+183WP_000923182.1DUF645 family protein-
GTF72_RS15395346347..346820+474WP_001161076.1GrpB family protein-
GTF72_RS15400346817..346927+111WP_071908312.1DUF3265 domain-containing protein-
GTF72_RS15405346969..347595+627WP_000365424.1LysE family translocator-
GTF72_RS15410347718..348416+699WP_001890502.1hypothetical protein-
GTF72_RS15415348420..348536+117WP_071908339.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306905..436165129260
insideIntegron--311985..435789123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T145807 WP_000578476.1 NZ_CP047296:c343921-343643 [Vibrio cholerae C6706]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T145807 NZ_CP062700:c697207-696743 [Escherichia coli O157:H7]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT145807 WP_000381183.1 NZ_CP047296:c344202-343918 [Vibrio cholerae C6706]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT145807 NZ_CP062700:c697542-697207 [Escherichia coli O157:H7]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAGCAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References