230526

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 385916..386682 Replicon chromosome
Accession NZ_CP090379
Organism Vibrio cholerae strain BY369

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag LVJ30_RS15905 Protein ID WP_000982260.1
Coordinates 385916..386413 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag LVJ30_RS15910 Protein ID WP_000246253.1
Coordinates 386410..386682 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ30_RS15845 (LVJ30_15845) 381778..382084 + 307 Protein_402 CatB-related O-acetyltransferase -
LVJ30_RS15850 (LVJ30_15850) 382221..382619 + 399 Protein_403 GNAT family N-acetyltransferase -
LVJ30_RS15855 (LVJ30_15855) 382743..382913 + 171 WP_001080654.1 hypothetical protein -
LVJ30_RS15860 (LVJ30_15860) 382913..383314 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
LVJ30_RS15865 (LVJ30_15865) 383317..383427 + 111 WP_082798255.1 DUF3265 domain-containing protein -
LVJ30_RS15870 (LVJ30_15870) 383502..383915 + 414 WP_000049417.1 VOC family protein -
LVJ30_RS15875 (LVJ30_15875) 384129..384380 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LVJ30_RS15880 (LVJ30_15880) 384370..384657 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
LVJ30_RS15885 (LVJ30_15885) 384785..385240 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
LVJ30_RS15890 (LVJ30_15890) 385297..385419 + 123 Protein_411 acetyltransferase -
LVJ30_RS15895 (LVJ30_15895) 385590..385714 + 125 Protein_412 DUF645 family protein -
LVJ30_RS15900 (LVJ30_15900) 385831..385899 + 69 Protein_413 acetyltransferase -
LVJ30_RS15905 (LVJ30_15905) 385916..386413 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
LVJ30_RS15910 (LVJ30_15910) 386410..386682 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
LVJ30_RS15915 (LVJ30_15915) 386834..386896 + 63 Protein_416 acetyltransferase -
LVJ30_RS15920 (LVJ30_15920) 386913..387581 + 669 WP_000043871.1 hypothetical protein -
LVJ30_RS15925 (LVJ30_15925) 387733..388020 + 288 WP_000426470.1 hypothetical protein -
LVJ30_RS15930 (LVJ30_15930) 388161..388532 + 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
LVJ30_RS15935 (LVJ30_15935) 388755..389024 + 270 WP_000179600.1 DUF1778 domain-containing protein -
LVJ30_RS15940 (LVJ30_15940) 389021..389554 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
LVJ30_RS15945 (LVJ30_15945) 389564..389674 + 111 WP_086010065.1 DUF3265 domain-containing protein -
LVJ30_RS15950 (LVJ30_15950) 389756..390013 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LVJ30_RS15955 (LVJ30_15955) 390001..390303 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
LVJ30_RS15960 (LVJ30_15960) 390537..391454 + 918 WP_000186333.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..399892 95247
inside Integron - - 309725..399516 89791
flank IS/Tn - - 380730..381710 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T230526 WP_000982260.1 NZ_CP090379:c386413-385916 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T230526 NZ_CP124918:1828165-1828509 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTCTCCCATTCGGATTATATTGAGTTATATAAAATTCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCAGATTAT
CATATGTTTAAATGTCTTATTGAAAAACATGACGAGCAATTTAATTATTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAATTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT230526 WP_000246253.1 NZ_CP090379:c386682-386410 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT230526 NZ_CP124918:1827816-1828148 [Enterococcus faecalis]
ATGAACCTCTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTATTTGAAAGGGAG
ATTCGGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References