Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 410525..411103 Replicon chromosome
Accession NZ_OW443148
Organism Vibrio cholerae strain CNRVC190243 isolate YE-NCPHL-19014-PI

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag OC617_RS15925 Protein ID WP_001180243.1
Coordinates 410525..410842 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag OC617_RS15930 Protein ID WP_000557292.1
Coordinates 410861..411103 (-) Length 81 a.a.

Genomic Context

OC617_RS15865OC617_RS15870OC617_RS15875OC617_RS15880OC617_RS15885OC617_RS15890OC617_RS15895OC617_RS15900OC617_RS15905OC617_RS15910OC617_RS15915OC617_RS15920OC617_RS15935OC617_RS15940OC617_RS15945OC617_RS15950OC617_RS15955OC617_RS15960OC617_RS15965OC617_RS15970OC617_RS15975OC617_RS15980OC617_RS15985OC617_RS15990OC617_RS15995OC617_RS16000OC617_RS15925OC617_RS15930
Location: 405755..406111 (357 bp)
Type: Others
Protein ID: WP_001094969.1
Location: 406210..406353 (144 bp)
Type: Others
Protein ID: Protein_396
Location: 406476..406595 (120 bp)
Type: Others
Protein ID: WP_001900954.1
Location: 406772..407167 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 407311..407847 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 408198..408260 (63 bp)
Type: Others
Protein ID: Protein_400
Location: 408250..408360 (111 bp)
Type: Others
Protein ID: WP_223804330.1
Location: 408519..408944 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 409093..409440 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 409587..409880 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 409943..410118 (176 bp)
Type: Others
Protein ID: Protein_405
Location: 410179..410331 (153 bp)
Type: Others
Protein ID: Protein_406
Location: 411345..411854 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 411911..412564 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 412653..412862 (210 bp)
Type: Others
Protein ID: WP_001900246.1
Location: 412874..413092 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 413281..413474 (194 bp)
Type: Others
Protein ID: Protein_413
Location: 413495..413728 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 414153..414333 (181 bp)
Type: Others
Protein ID: Protein_415
Location: 414446..414559 (114 bp)
Type: Others
Protein ID: WP_001894955.1
Location: 414600..414887 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 414898..415215 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 415212..415322 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 415361..415471 (111 bp)
Type: Others
Protein ID: Protein_420
Location: 415499..415624 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 415587..415703 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 410525..410842 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 410861..411103 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
OC617_RS15865 (CNRVC190243H_03134)405755..406111+357WP_001094969.1DUF6404 family protein-
OC617_RS15870406210..406353+144Protein_396acetyltransferase-
OC617_RS15875406476..406595+120WP_001900954.1DUF645 family protein-
OC617_RS15880 (CNRVC190243H_03135)406772..407167+396WP_000046953.1DUF6404 family protein-
OC617_RS15885 (CNRVC190243H_03136)407311..407847+537WP_000644491.1nucleotidyltransferase family protein-
OC617_RS15890408198..408260+63Protein_400DUF645 family protein-
OC617_RS15895408250..408360+111WP_223804330.1Tfp pilus assembly protein-
OC617_RS15900 (CNRVC190243H_03137)408519..408944+426WP_000403014.1GNAT family N-acetyltransferase-
OC617_RS15905 (CNRVC190243H_03138)409093..409440+348WP_000933409.1hypothetical protein-
OC617_RS15910409587..409880+294WP_125460920.1hypothetical protein-
OC617_RS15915409943..410118+176Protein_405acetyltransferase-
OC617_RS15920410179..410331+153Protein_406DUF645 family protein-
OC617_RS15925 (CNRVC190243H_03139)410525..410842-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
OC617_RS15930 (CNRVC190243H_03140)410861..411103-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
OC617_RS15935 (CNRVC190243H_03141)411345..411854+510WP_000405987.1GNAT family N-acetyltransferase-
OC617_RS15940 (CNRVC190243H_03142)411911..412564+654WP_000226874.1hypothetical protein-
OC617_RS15945412653..412862+210WP_001900246.1DUF3709 domain-containing protein-
OC617_RS15950412874..413092+219WP_001917086.1DUF3709 domain-containing protein-
OC617_RS15955413281..413474+194Protein_413hypothetical protein-
OC617_RS15960413495..413728+234WP_032482776.1DUF3709 domain-containing protein-
OC617_RS15965414153..414333+181Protein_415DUF645 family protein-
OC617_RS15970414446..414559+114WP_001894955.1hypothetical protein-
OC617_RS15975 (CNRVC190243H_03143)414600..414887+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
OC617_RS15980 (CNRVC190243H_03144)414898..415215+318WP_001232701.1HigA family addiction module antitoxin-
OC617_RS15985415212..415322+111WP_134814058.1DUF3265 domain-containing protein-
OC617_RS15990415361..415471+111Protein_420acetyltransferase-
OC617_RS15995415499..415624+126WP_001944767.1DUF645 family protein-
OC617_RS16000415587..415703+117WP_001889170.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-349905..456410106505
insideIntegroncatB9-354985..456034101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T295392 WP_001180243.1 NZ_OW443148:c410842-410525 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT295392 WP_000557292.1 NZ_OW443148:c411103-410861 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References