23789

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 995791..996369 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag VCD_RS19195 Protein ID WP_001180243.1
Coordinates 996052..996369 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag VCD_RS19190 Protein ID WP_000557292.1
Coordinates 995791..996033 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCD_RS20895 991216..991254 - 39 WP_106019119.1 hypothetical protein -
VCD_RS20430 991270..991395 - 126 WP_001944767.1 DUF645 family protein -
VCD_RS21075 991572..991682 - 111 WP_134814058.1 DUF3265 domain-containing protein -
VCD_RS19160 991679..991996 - 318 WP_001232701.1 HigA family addiction module antidote protein -
VCD_RS19165 992007..992294 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
VCD_RS19170 992561..992741 - 181 Protein_892 DUF645 family protein -
VCD_RS20440 993166..993399 - 234 WP_032482776.1 DUF3709 domain-containing protein -
VCD_RS19175 993802..994020 - 219 WP_001917086.1 DUF3709 domain-containing protein -
VCD_RS19180 994330..994983 - 654 WP_000226874.1 hypothetical protein -
VCD_RS19185 995040..995549 - 510 WP_000405987.1 GNAT family N-acetyltransferase -
VCD_RS19190 995791..996033 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VCD_RS19195 996052..996369 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VCD_RS21080 996563..996658 - 96 WP_001907607.1 DUF645 family protein -
VCD_RS20905 997014..997307 - 294 WP_125460920.1 hypothetical protein -
VCD_RS19200 997454..997801 - 348 WP_000933409.1 hypothetical protein -
VCD_RS19205 997950..998375 - 426 WP_000403014.1 GNAT family N-acetyltransferase -
VCD_RS19210 998571..998750 - 180 WP_001883039.1 DUF645 family protein -
VCD_RS19220 999047..999583 - 537 WP_000644491.1 nucleotidyltransferase family protein -
VCD_RS19225 999727..1000122 - 396 WP_000046953.1 hypothetical protein -
VCD_RS20460 1000299..1000480 - 182 Protein_906 DUF645 family protein -
VCD_RS19230 1000783..1001178 - 396 WP_000046952.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932253..1057432 125179
inside Integron - - 958376..1050596 92220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T23789 WP_001180243.1 NC_012667:996052-996369 [Vibrio cholerae MJ-1236]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T23789 NC_012667:996052-996369 [Vibrio cholerae MJ-1236]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT23789 WP_000557292.1 NC_012667:995791-996033 [Vibrio cholerae MJ-1236]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT23789 NC_012667:995791-996033 [Vibrio cholerae MJ-1236]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References