Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 995791..996369 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag VCD_RS19195 Protein ID WP_001180243.1
Coordinates 996052..996369 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag VCD_RS19190 Protein ID WP_000557292.1
Coordinates 995791..996033 (+) Length 81 a.a.

Genomic Context

VCD_RS19190VCD_RS19195VCD_RS20895VCD_RS20430VCD_RS21075VCD_RS19160VCD_RS19165VCD_RS19170VCD_RS20440VCD_RS19175VCD_RS19180VCD_RS19185VCD_RS21080VCD_RS20905VCD_RS19200VCD_RS19205VCD_RS19210VCD_RS19220VCD_RS19225VCD_RS20460VCD_RS19230
Location: 995791..996033 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 996052..996369 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 991216..991254 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 991270..991395 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 991572..991682 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 991679..991996 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 992007..992294 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 992561..992741 (181 bp)
Type: Others
Protein ID: Protein_892
Location: 993166..993399 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 993802..994020 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 994330..994983 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 995040..995549 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 996563..996658 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 997014..997307 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 997454..997801 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 997950..998375 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 998571..998750 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 999047..999583 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 999727..1000122 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 1000299..1000480 (182 bp)
Type: Others
Protein ID: Protein_906
Location: 1000783..1001178 (396 bp)
Type: Others
Protein ID: WP_000046952.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCD_RS20895991216..991254-39WP_106019119.1hypothetical protein-
VCD_RS20430991270..991395-126WP_001944767.1DUF645 family protein-
VCD_RS21075991572..991682-111WP_134814058.1DUF3265 domain-containing protein-
VCD_RS19160991679..991996-318WP_001232701.1HigA family addiction module antidote protein-
VCD_RS19165992007..992294-288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
VCD_RS19170992561..992741-181Protein_892DUF645 family protein-
VCD_RS20440993166..993399-234WP_032482776.1DUF3709 domain-containing protein-
VCD_RS19175993802..994020-219WP_001917086.1DUF3709 domain-containing protein-
VCD_RS19180994330..994983-654WP_000226874.1hypothetical protein-
VCD_RS19185995040..995549-510WP_000405987.1GNAT family N-acetyltransferase-
VCD_RS19190995791..996033+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
VCD_RS19195996052..996369+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
VCD_RS21080996563..996658-96WP_001907607.1DUF645 family protein-
VCD_RS20905997014..997307-294WP_125460920.1hypothetical protein-
VCD_RS19200997454..997801-348WP_000933409.1hypothetical protein-
VCD_RS19205997950..998375-426WP_000403014.1GNAT family N-acetyltransferase-
VCD_RS19210998571..998750-180WP_001883039.1DUF645 family protein-
VCD_RS19220999047..999583-537WP_000644491.1nucleotidyltransferase family protein-
VCD_RS19225999727..1000122-396WP_000046953.1hypothetical protein-
VCD_RS204601000299..1000480-182Protein_906DUF645 family protein-
VCD_RS192301000783..1001178-396WP_000046952.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932253..1057432125179
insideIntegron--958376..105059692220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T23789 WP_001180243.1 NC_012667:996052-996369 [Vibrio cholerae MJ-1236]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T23789 NC_012667:996052-996369 [Vibrio cholerae MJ-1236]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT23789 WP_000557292.1 NC_012667:995791-996033 [Vibrio cholerae MJ-1236]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT23789 NC_012667:995791-996033 [Vibrio cholerae MJ-1236]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References