145887

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 344229..344788 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag GTF74_RS15385 Protein ID WP_000578476.1
Coordinates 344229..344507 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GTF74_RS15390 Protein ID WP_000381183.1
Coordinates 344504..344788 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF74_RS15335 339307..339813 + 507 WP_000393074.1 hypothetical protein -
GTF74_RS15340 339970..340356 + 387 WP_000703163.1 VOC family protein -
GTF74_RS15345 340613..340816 + 204 WP_001911580.1 hypothetical protein -
GTF74_RS15350 341011..341262 + 252 WP_001890111.1 TIGR03643 family protein -
GTF74_RS15355 341235..341384 + 150 WP_071908333.1 DUF3265 domain-containing protein -
GTF74_RS15360 341531..341956 + 426 WP_000415750.1 hypothetical protein -
GTF74_RS15365 342162..342785 + 624 WP_000247070.1 DUF1349 domain-containing protein -
GTF74_RS15370 342998..343477 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
GTF74_RS15375 343665..344078 + 414 WP_000049420.1 VOC family protein -
GTF74_RS15380 344085..344180 - 96 Protein_322 hypothetical protein -
GTF74_RS15385 344229..344507 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GTF74_RS15390 344504..344788 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GTF74_RS15395 344983..345498 + 516 WP_001201520.1 lipocalin family protein -
GTF74_RS15400 345563..346159 + 597 WP_000255434.1 hypothetical protein -
GTF74_RS15405 346551..346733 + 183 WP_000923182.1 DUF645 family protein -
GTF74_RS15410 346933..347406 + 474 WP_001161076.1 GrpB family protein -
GTF74_RS15415 347403..347513 + 111 WP_071908312.1 DUF3265 domain-containing protein -
GTF74_RS15420 347555..348181 + 627 WP_000365424.1 LysE family translocator -
GTF74_RS15425 348304..349002 + 699 WP_001890502.1 hypothetical protein -
GTF74_RS15430 349006..349122 + 117 WP_071908339.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 307032..436751 129719
inside Integron - - 312112..436375 124263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T145887 WP_000578476.1 NZ_CP047304:c344507-344229 [Vibrio cholerae O1 biovar El Tor]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T145887 NZ_CP062705:c5060509-5060336 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT145887 WP_000381183.1 NZ_CP047304:c344788-344504 [Vibrio cholerae O1 biovar El Tor]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT145887 NZ_CP062705:c5060833-5060537 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References