Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 933469..933997 Replicon chromosome
Accession NZ_LT992487
Organism Vibrio cholerae strain 4295STDY6534216

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag DG247_RS18695 Protein ID WP_000221352.1
Coordinates 933707..933997 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag DG247_RS18690 Protein ID WP_000213183.1
Coordinates 933469..933717 (+) Length 83 a.a.

Genomic Context

DG247_RS18640DG247_RS18690DG247_RS18695DG247_RS18645DG247_RS18655DG247_RS18660DG247_RS18665DG247_RS18670DG247_RS18675DG247_RS18700DG247_RS18705DG247_RS18710DG247_RS18715DG247_RS18720DG247_RS18725DG247_RS19820DG247_RS19825DG247_RS19830
Location: 928504..928968 (465 bp)
Type: Others
Protein ID: WP_000140244.1
Location: 933469..933717 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 933707..933997 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 929068..929470 (403 bp)
Type: Others
Protein ID: Protein_811
Location: 929626..930126 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 930264..930794 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 930945..931340 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 931548..931973 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 932245..932898 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 934133..934648 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 934785..935261 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 935289..935399 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 935396..936325 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 936445..936891 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 937044..938048 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 938261..938299 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 938315..938440 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 938617..938727 (111 bp)
Type: Others
Protein ID: WP_134814058.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG247_RS18640928504..928968+465WP_000140244.1hypothetical protein-
DG247_RS18645929068..929470-403Protein_811hypothetical protein-
DG247_RS18655929626..930126-501WP_000789723.1hypothetical protein-
DG247_RS18660930264..930794-531WP_000415563.1hypothetical protein-
DG247_RS18665930945..931340-396WP_000649527.1DUF3465 domain-containing protein-
DG247_RS18670931548..931973-426WP_000415748.1hypothetical protein-
DG247_RS18675932245..932898-654WP_000036957.1site-specific DNA-methyltransferase-
DG247_RS18690933469..933717+249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
DG247_RS18695933707..933997+291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DG247_RS18700934133..934648-516WP_001201528.1lipocalin family protein-
DG247_RS18705934785..935261-477WP_001047180.1GNAT family N-acetyltransferase-
DG247_RS18710935289..935399-111WP_071917832.1DUF3265 domain-containing protein-
DG247_RS18715935396..936325-930WP_000335802.1hypothetical protein-
DG247_RS18720936445..936891-447WP_000128977.1hypothetical protein-
DG247_RS18725937044..938048-1005WP_000964925.1LD-carboxypeptidase-
DG247_RS19820938261..938299-39WP_106019119.1hypothetical protein-
DG247_RS19825938315..938440-126WP_001944767.1DUF645 family protein-
DG247_RS19830938617..938727-111WP_134814058.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-897525..99449796972
insideIntegroncatB9-897901..98770989808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T294357 WP_000221352.1 NZ_LT992487:933707-933997 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT294357 WP_000213183.1 NZ_LT992487:933469-933717 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References