58373

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 112170..112936 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ83_RS14525 Protein ID WP_000982260.1
Coordinates 112170..112667 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ83_RS14530 Protein ID WP_000246253.1
Coordinates 112664..112936 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ83_RS14475 107612..108316 + 705 WP_000087610.1 HNH endonuclease -
ASZ83_RS14480 108474..108812 + 339 WP_000713853.1 hypothetical protein -
ASZ83_RS14485 108966..109283 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ83_RS14490 109302..109544 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ83_RS14495 109788..110174 + 387 WP_001015867.1 NUDIX hydrolase -
ASZ83_RS14500 110231..110344 + 114 WP_001900214.1 hypothetical protein -
ASZ83_RS14505 110293..110574 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ83_RS14515 110832..111368 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ83_RS14520 111505..112020 + 516 WP_001201509.1 lipocalin family protein -
ASZ83_RS14525 112170..112667 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
ASZ83_RS14530 112664..112936 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
ASZ83_RS19990 113329..113454 + 126 WP_001900195.1 DUF645 family protein -
ASZ83_RS19995 113470..113508 + 39 WP_106019118.1 hypothetical protein -
ASZ83_RS14540 113704..114150 + 447 WP_000006157.1 hypothetical protein -
ASZ83_RS14545 114298..114567 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
ASZ83_RS14550 114560..114838 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ASZ83_RS14555 115088..115345 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ83_RS14560 115333..115635 + 303 WP_000229318.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ83_RS14565 115924..116148 + 225 WP_001894423.1 DUF3709 domain-containing protein -
ASZ83_RS14570 116592..116711 + 120 WP_071919600.1 DUF645 family protein -
ASZ83_RS20010 116715..116768 + 54 Protein_123 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 87981..224211 136230
inside Integron - - 93061..221594 128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58373 WP_000982260.1 NZ_CP013316:c112667-112170 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58373 NZ_CP013316:c112667-112170 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58373 WP_000246253.1 NZ_CP013316:c112936-112664 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58373 NZ_CP013316:c112936-112664 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References