Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 112170..112936 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ83_RS14525 Protein ID WP_000982260.1
Coordinates 112170..112667 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ83_RS14530 Protein ID WP_000246253.1
Coordinates 112664..112936 (-) Length 91 a.a.

Genomic Context

ASZ83_RS14475ASZ83_RS14480ASZ83_RS14495ASZ83_RS14500ASZ83_RS14505ASZ83_RS14515ASZ83_RS14520ASZ83_RS19990ASZ83_RS19995ASZ83_RS14540ASZ83_RS14555ASZ83_RS14560ASZ83_RS14565ASZ83_RS14570ASZ83_RS20010ASZ83_RS14485ASZ83_RS14490ASZ83_RS14525ASZ83_RS14530ASZ83_RS14545ASZ83_RS14550
Location: 107612..108316 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 108474..108812 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 109788..110174 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 110231..110344 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 110293..110574 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 110832..111368 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 111505..112020 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 113329..113454 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 113470..113508 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 113704..114150 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 115088..115345 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 115333..115635 (303 bp)
Type: Others
Protein ID: WP_000229318.1
Location: 115924..116148 (225 bp)
Type: Others
Protein ID: WP_001894423.1
Location: 116592..116711 (120 bp)
Type: Others
Protein ID: WP_071919600.1
Location: 116715..116768 (54 bp)
Type: Others
Protein ID: Protein_123
Location: 108966..109283 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 109302..109544 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 112170..112667 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 112664..112936 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 114298..114567 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 114560..114838 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ83_RS14475107612..108316+705WP_000087610.1HNH endonuclease-
ASZ83_RS14480108474..108812+339WP_000713853.1hypothetical protein-
ASZ83_RS14485108966..109283-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ83_RS14490109302..109544-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ83_RS14495109788..110174+387WP_001015867.1NUDIX hydrolase-
ASZ83_RS14500110231..110344+114WP_001900214.1hypothetical protein-
ASZ83_RS14505110293..110574+282WP_001894429.1DUF1289 domain-containing protein-
ASZ83_RS14515110832..111368+537WP_000469482.1GNAT family N-acetyltransferase-
ASZ83_RS14520111505..112020+516WP_001201509.1lipocalin family protein-
ASZ83_RS14525112170..112667-498WP_000982260.1GNAT family N-acetyltransferaseToxin
ASZ83_RS14530112664..112936-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
ASZ83_RS19990113329..113454+126WP_001900195.1DUF645 family protein-
ASZ83_RS19995113470..113508+39WP_106019118.1hypothetical protein-
ASZ83_RS14540113704..114150+447WP_000006157.1hypothetical protein-
ASZ83_RS14545114298..114567-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
ASZ83_RS14550114560..114838-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
ASZ83_RS14555115088..115345+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ83_RS14560115333..115635+303WP_000229318.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ83_RS14565115924..116148+225WP_001894423.1DUF3709 domain-containing protein-
ASZ83_RS14570116592..116711+120WP_071919600.1DUF645 family protein-
ASZ83_RS20010116715..116768+54Protein_123DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--87981..224211136230
insideIntegron--93061..221594128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58373 WP_000982260.1 NZ_CP013316:c112667-112170 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58373 NZ_CP013316:c112667-112170 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58373 WP_000246253.1 NZ_CP013316:c112936-112664 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58373 NZ_CP013316:c112936-112664 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References