145866

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 327907..328447 Replicon chromosome
Accession NZ_CP047302
Organism Vibrio cholerae O1 biovar El Tor strain DRC-193A

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag GTF75_RS15355 Protein ID WP_000277238.1
Coordinates 327907..328176 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag GTF75_RS15360 Protein ID WP_001258569.1
Coordinates 328169..328447 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF75_RS15295 322911..323153 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GTF75_RS15300 323397..323783 + 387 WP_001015867.1 NUDIX hydrolase -
GTF75_RS15305 323840..323953 + 114 WP_001900214.1 hypothetical protein -
GTF75_RS15310 323902..324183 + 282 WP_001894429.1 DUF1289 domain-containing protein -
GTF75_RS15315 324159..324317 - 159 WP_001886450.1 DUF1196 family protein -
GTF75_RS15320 324441..324977 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
GTF75_RS15325 325114..325629 + 516 WP_001201509.1 lipocalin family protein -
GTF75_RS15330 325779..326276 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GTF75_RS15335 326273..326545 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GTF75_RS15340 326938..327063 + 126 WP_001900195.1 DUF645 family protein -
GTF75_RS15345 327079..327117 + 39 WP_106019118.1 hypothetical protein -
GTF75_RS15350 327313..327759 + 447 WP_000006157.1 hypothetical protein -
GTF75_RS15355 327907..328176 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
GTF75_RS15360 328169..328447 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GTF75_RS15365 328733..329011 + 279 WP_001921601.1 DUF3709 domain-containing protein -
GTF75_RS15370 329263..329469 + 207 Protein_293 DUF3709 domain-containing protein -
GTF75_RS15375 329669..329770 + 102 WP_001921603.1 hypothetical protein -
GTF75_RS15380 329760..330146 + 387 WP_000703163.1 VOC family protein -
GTF75_RS15385 330341..330592 + 252 WP_001890111.1 TIGR03643 family protein -
GTF75_RS15390 330565..330714 + 150 WP_071908333.1 DUF3265 domain-containing protein -
GTF75_RS15395 330806..331048 + 243 WP_000107461.1 hypothetical protein -
GTF75_RS15400 331300..331578 + 279 WP_000280324.1 DUF3709 domain-containing protein -
GTF75_RS15405 331953..332096 + 144 Protein_300 DUF645 family protein -
GTF75_RS15410 332150..332188 + 39 WP_082798268.1 hypothetical protein -
GTF75_RS15415 332400..332867 + 468 WP_001289288.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305935..411136 105201
inside Integron - - 311015..410760 99745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T145866 WP_000277238.1 NZ_CP047302:c328176-327907 [Vibrio cholerae O1 biovar El Tor]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T145866 NZ_CP062705:c458523-458038 [Escherichia coli O157:H7]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT145866 WP_001258569.1 NZ_CP047302:c328447-328169 [Vibrio cholerae O1 biovar El Tor]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT145866 NZ_CP062705:c458792-458514 [Escherichia coli O157:H7]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References