230651

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 924930..925508 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag LZM82_RS18115 Protein ID WP_001180243.1
Coordinates 925191..925508 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag LZM82_RS18110 Protein ID WP_000557292.1
Coordinates 924930..925172 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZM82_RS18060 (LZM82_18060) 920324..920770 - 447 WP_000006157.1 hypothetical protein -
LZM82_RS18065 (LZM82_18065) 921020..921145 - 126 WP_001900195.1 DUF645 family protein -
LZM82_RS18070 (LZM82_18070) 921538..921810 + 273 WP_000246253.1 DUF1778 domain-containing protein -
LZM82_RS18075 (LZM82_18075) 921807..922304 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
LZM82_RS18080 (LZM82_18080) 922321..922389 - 69 Protein_884 acetyltransferase -
LZM82_RS18085 (LZM82_18085) 922454..922915 - 462 WP_001903091.1 lipocalin family protein -
LZM82_RS18090 (LZM82_18090) 923106..923642 - 537 WP_000469482.1 GNAT family protein -
LZM82_RS18095 (LZM82_18095) 923900..924121 - 222 WP_032467793.1 DUF1289 domain-containing protein -
LZM82_RS18100 (LZM82_18100) 924130..924243 - 114 WP_001900214.1 hypothetical protein -
LZM82_RS18105 (LZM82_18105) 924300..924686 - 387 WP_001015867.1 NUDIX hydrolase -
LZM82_RS18110 (LZM82_18110) 924930..925172 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LZM82_RS18115 (LZM82_18115) 925191..925508 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZM82_RS18120 (LZM82_18120) 925662..926000 - 339 WP_000713853.1 hypothetical protein -
LZM82_RS18125 (LZM82_18125) 926158..926862 - 705 WP_000087610.1 HNH endonuclease -
LZM82_RS18130 (LZM82_18130) 927024..928232 - 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
LZM82_RS18135 (LZM82_18135) 928394..929071 - 678 WP_000254617.1 HNH endonuclease signature motif containing protein -
LZM82_RS18140 (LZM82_18140) 929266..929448 - 183 WP_000923153.1 DUF645 family protein -
LZM82_RS18145 (LZM82_18145) 929620..929682 - 63 Protein_897 acetyltransferase -
LZM82_RS18150 (LZM82_18150) 929802..929984 - 183 WP_000923340.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 835643..943910 108267
inside Integron - - 836019..937068 101049
- flank IS/Tn - - 919050..920261 1211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T230651 WP_001180243.1 NZ_CP090400:925191-925508 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T230651 NZ_CP125279:c1297189-1296443 [Bacillus velezensis]
ATGCTTATGTTTTTTCAGATTATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT230651 WP_000557292.1 NZ_CP090400:924930-925172 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT230651 NZ_CP125279:c1296442-1296272 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References