Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 924930..925508 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag LZM82_RS18115 Protein ID WP_001180243.1
Coordinates 925191..925508 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag LZM82_RS18110 Protein ID WP_000557292.1
Coordinates 924930..925172 (+) Length 81 a.a.

Genomic Context

LZM82_RS18070LZM82_RS18075LZM82_RS18110LZM82_RS18115LZM82_RS18060LZM82_RS18065LZM82_RS18080LZM82_RS18085LZM82_RS18090LZM82_RS18095LZM82_RS18100LZM82_RS18105LZM82_RS18120LZM82_RS18125LZM82_RS18130LZM82_RS18135LZM82_RS18140LZM82_RS18145LZM82_RS18150
Location: 921538..921810 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 921807..922304 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 924930..925172 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 925191..925508 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 920324..920770 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 921020..921145 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 922321..922389 (69 bp)
Type: Others
Protein ID: Protein_884
Location: 922454..922915 (462 bp)
Type: Others
Protein ID: WP_001903091.1
Location: 923106..923642 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 923900..924121 (222 bp)
Type: Others
Protein ID: WP_032467793.1
Location: 924130..924243 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 924300..924686 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 925662..926000 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 926158..926862 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 927024..928232 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 928394..929071 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 929266..929448 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 929620..929682 (63 bp)
Type: Others
Protein ID: Protein_897
Location: 929802..929984 (183 bp)
Type: Others
Protein ID: WP_000923340.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LZM82_RS18060 (LZM82_18060)920324..920770-447WP_000006157.1hypothetical protein-
LZM82_RS18065 (LZM82_18065)921020..921145-126WP_001900195.1DUF645 family protein-
LZM82_RS18070 (LZM82_18070)921538..921810+273WP_000246253.1DUF1778 domain-containing protein-
LZM82_RS18075 (LZM82_18075)921807..922304+498WP_000982260.1GNAT family N-acetyltransferase-
LZM82_RS18080 (LZM82_18080)922321..922389-69Protein_884acetyltransferase-
LZM82_RS18085 (LZM82_18085)922454..922915-462WP_001903091.1lipocalin family protein-
LZM82_RS18090 (LZM82_18090)923106..923642-537WP_000469482.1GNAT family protein-
LZM82_RS18095 (LZM82_18095)923900..924121-222WP_032467793.1DUF1289 domain-containing protein-
LZM82_RS18100 (LZM82_18100)924130..924243-114WP_001900214.1hypothetical protein-
LZM82_RS18105 (LZM82_18105)924300..924686-387WP_001015867.1NUDIX hydrolase-
LZM82_RS18110 (LZM82_18110)924930..925172+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
LZM82_RS18115 (LZM82_18115)925191..925508+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LZM82_RS18120 (LZM82_18120)925662..926000-339WP_000713853.1hypothetical protein-
LZM82_RS18125 (LZM82_18125)926158..926862-705WP_000087610.1HNH endonuclease-
LZM82_RS18130 (LZM82_18130)927024..928232-1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
LZM82_RS18135 (LZM82_18135)928394..929071-678WP_000254617.1HNH endonuclease signature motif containing protein-
LZM82_RS18140 (LZM82_18140)929266..929448-183WP_000923153.1DUF645 family protein-
LZM82_RS18145 (LZM82_18145)929620..929682-63Protein_897acetyltransferase-
LZM82_RS18150 (LZM82_18150)929802..929984-183WP_000923340.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-835643..943910108267
insideIntegron--836019..937068101049
-flankIS/Tn--919050..9202611211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T230651 WP_001180243.1 NZ_CP090400:925191-925508 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T230651 NZ_CP125279:c1297189-1296443 [Bacillus velezensis]
ATGCTTATGTTTTTTCAGATTATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT230651 WP_000557292.1 NZ_CP090400:924930-925172 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT230651 NZ_CP125279:c1296442-1296272 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References