Detailed information of TA system TA104338

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 334822..335320
• Replicon: chromosome
• Accession: NZ_CP028895
• Organism: Vibrio cholerae strain A1552

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK7
• Locus tag: A1552VC_RS15875
• Protein ID: WP_000589156.1
• Coordinates: 334822..335088 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK6
• Locus tag: A1552VC_RS15880
• Protein ID: WP_000643598.1
• Coordinates: 335075..335320 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A1552VC_RS15815	330242..330448	+	207	Protein_292	DUF3709 domain-containing protein	-
A1552VC_RS15820	330648..330749	+	102	WP_001921603.1	hypothetical protein	-
A1552VC_RS15825	330739..331125	+	387	WP_000703163.1	VOC family protein	-
A1552VC_RS15830	331320..331571	+	252	WP_001890111.1	TIGR03643 family protein	-
A1552VC_RS15835	331544..331693	+	150	WP_071908333.1	DUF3265 domain-containing protein	-
A1552VC_RS15840	331785..332027	+	243	WP_000107461.1	hypothetical protein	-
A1552VC_RS15845	332279..332557	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
A1552VC_RS20015	332932..333075	+	144	Protein_299	DUF645 family protein	-
A1552VC_RS20020	333129..333167	+	39	WP_082798268.1	hypothetical protein	-
A1552VC_RS15860	333379..333846	+	468	WP_001289288.1	OsmC family protein	-
A1552VC_RS15865	333974..334637	+	664	Protein_302	hypothetical protein	-
A1552VC_RS15875	334822..335088	+	267	WP_000589156.1	BrnT family toxin	Toxin
A1552VC_RS15880	335075..335320	+	246	WP_000643598.1	hypothetical protein	Antitoxin
A1552VC_RS15885	335416..336210	+	795	WP_001911581.1	hypothetical protein	-
A1552VC_RS20035	336313..336441	+	129	WP_071908338.1	general secretion pathway protein GspI	-
A1552VC_RS15900	336502..336684	+	183	WP_000923182.1	DUF645 family protein	-
A1552VC_RS15905	336900..337904	+	1005	WP_000964920.1	LD-carboxypeptidase	-
A1552VC_RS15910	338057..338416	+	360	WP_001071541.1	VOC family protein	-
A1552VC_RS15915	338689..338922	+	234	WP_001890112.1	DUF3709 domain-containing protein	-
A1552VC_RS15920	339190..339696	+	507	WP_000393074.1	hypothetical protein	-
A1552VC_RS15925	339853..340239	+	387	WP_000703163.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	306914..436175	129261
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0	inside	Integron	-	-	311994..435799	123805

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10092.34 Da
• Isoelectric Point: 7.3171

>T104338 WP_000589156.1 NZ_CP028895:334822-335088 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Nucleotide

• Length: 267 bp

>T104338 NZ_CP028895:334822-335088 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9478.77 Da
• Isoelectric Point: 6.4832

>AT104338 WP_000643598.1 NZ_CP028895:335075-335320 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Nucleotide

• Length: 246 bp

>AT104338 NZ_CP028895:335075-335320 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Structures

Toxin

• AlphaFold DB: A0A271VMP7

Antitoxin

• AlphaFold DB: A0A271VME2