Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 334822..335320 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag A1552VC_RS15875 Protein ID WP_000589156.1
Coordinates 334822..335088 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag A1552VC_RS15880 Protein ID WP_000643598.1
Coordinates 335075..335320 (+) Length 82 a.a.

Genomic Context

A1552VC_RS15815A1552VC_RS15820A1552VC_RS15825A1552VC_RS15830A1552VC_RS15835A1552VC_RS15840A1552VC_RS15845A1552VC_RS20015A1552VC_RS20020A1552VC_RS15860A1552VC_RS15865A1552VC_RS15875A1552VC_RS15880A1552VC_RS15885A1552VC_RS20035A1552VC_RS15900A1552VC_RS15905A1552VC_RS15910A1552VC_RS15915A1552VC_RS15920A1552VC_RS15925
Location: 330242..330448 (207 bp)
Type: Others
Protein ID: Protein_292
Location: 330648..330749 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 330739..331125 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 331320..331571 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 331544..331693 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 331785..332027 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 332279..332557 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 332932..333075 (144 bp)
Type: Others
Protein ID: Protein_299
Location: 333129..333167 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 333379..333846 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 333974..334637 (664 bp)
Type: Others
Protein ID: Protein_302
Location: 334822..335088 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 335075..335320 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 335416..336210 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 336313..336441 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 336502..336684 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 336900..337904 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 338057..338416 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 338689..338922 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 339190..339696 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 339853..340239 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A1552VC_RS15815330242..330448+207Protein_292DUF3709 domain-containing protein-
A1552VC_RS15820330648..330749+102WP_001921603.1hypothetical protein-
A1552VC_RS15825330739..331125+387WP_000703163.1VOC family protein-
A1552VC_RS15830331320..331571+252WP_001890111.1TIGR03643 family protein-
A1552VC_RS15835331544..331693+150WP_071908333.1DUF3265 domain-containing protein-
A1552VC_RS15840331785..332027+243WP_000107461.1hypothetical protein-
A1552VC_RS15845332279..332557+279WP_000280324.1DUF3709 domain-containing protein-
A1552VC_RS20015332932..333075+144Protein_299DUF645 family protein-
A1552VC_RS20020333129..333167+39WP_082798268.1hypothetical protein-
A1552VC_RS15860333379..333846+468WP_001289288.1OsmC family protein-
A1552VC_RS15865333974..334637+664Protein_302hypothetical protein-
A1552VC_RS15875334822..335088+267WP_000589156.1BrnT family toxinToxin
A1552VC_RS15880335075..335320+246WP_000643598.1hypothetical proteinAntitoxin
A1552VC_RS15885335416..336210+795WP_001911581.1hypothetical protein-
A1552VC_RS20035336313..336441+129WP_071908338.1general secretion pathway protein GspI-
A1552VC_RS15900336502..336684+183WP_000923182.1DUF645 family protein-
A1552VC_RS15905336900..337904+1005WP_000964920.1LD-carboxypeptidase-
A1552VC_RS15910338057..338416+360WP_001071541.1VOC family protein-
A1552VC_RS15915338689..338922+234WP_001890112.1DUF3709 domain-containing protein-
A1552VC_RS15920339190..339696+507WP_000393074.1hypothetical protein-
A1552VC_RS15925339853..340239+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306914..436175129261
insideIntegron--311994..435799123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T104338 WP_000589156.1 NZ_CP028895:334822-335088 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T104338 NZ_CP028895:334822-335088 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT104338 WP_000643598.1 NZ_CP028895:335075-335320 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT104338 NZ_CP028895:335075-335320 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References