Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 402948..403563 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag ASZ80_RS16475 Protein ID WP_001162670.1
Coordinates 402948..403235 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ASZ80_RS16480 Protein ID WP_001232701.1
Coordinates 403246..403563 (+) Length 106 a.a.

Genomic Context

ASZ80_RS20965ASZ80_RS16445ASZ80_RS16450ASZ80_RS16455ASZ80_RS16465ASZ80_RS16470ASZ80_RS16475ASZ80_RS16480ASZ80_RS20970ASZ80_RS20975ASZ80_RS20980ASZ80_RS16500ASZ80_RS16505ASZ80_RS16510ASZ80_RS16520ASZ80_RS16525ASZ80_RS16435ASZ80_RS16440
Location: 398584..398679 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 399693..400202 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 400259..400912 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 401222..401440 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 401843..402076 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 402501..402681 (181 bp)
Type: Others
Protein ID: Protein_419
Location: 402948..403235 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 403246..403563 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 403560..403670 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 403847..403972 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 403988..404026 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 404250..404990 (741 bp)
Type: Others
Protein ID: WP_000469836.1
Location: 405195..406025 (831 bp)
Type: Others
Protein ID: WP_000056616.1
Location: 406082..406564 (483 bp)
Type: Others
Protein ID: WP_001895003.1
Location: 407011..407886 (876 bp)
Type: Others
Protein ID: WP_000259044.1
Location: 408016..408471 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 398873..399190 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 399209..399451 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ80_RS20965398584..398679+96WP_001907607.1DUF645 family protein-
ASZ80_RS16435398873..399190-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ80_RS16440399209..399451-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ80_RS16445399693..400202+510WP_000405987.1GNAT family N-acetyltransferase-
ASZ80_RS16450400259..400912+654WP_000226874.1hypothetical protein-
ASZ80_RS16455401222..401440+219WP_001917086.1DUF3709 domain-containing protein-
ASZ80_RS16465401843..402076+234WP_032482776.1DUF3709 domain-containing protein-
ASZ80_RS16470402501..402681+181Protein_419DUF645 family protein-
ASZ80_RS16475402948..403235+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ80_RS16480403246..403563+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
ASZ80_RS20970403560..403670+111WP_134814058.1DUF3265 domain-containing protein-
ASZ80_RS20975403847..403972+126WP_001944767.1DUF645 family protein-
ASZ80_RS20980403988..404026+39WP_106019119.1hypothetical protein-
ASZ80_RS16500404250..404990+741WP_000469836.1PhzF family phenazine biosynthesis protein-
ASZ80_RS16505405195..406025+831WP_000056616.1abortive infection family protein-
ASZ80_RS16510406082..406564+483WP_001895003.1hypothetical protein-
ASZ80_RS16520407011..407886+876WP_000259044.1hypothetical protein-
ASZ80_RS16525408016..408471+456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304694..469286164592
insideIntegron--309774..468910159136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T58225 WP_001162670.1 NZ_CP013302:402948-403235 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T58225 NZ_CP013302:402948-403235 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT58225 WP_001232701.1 NZ_CP013302:403246-403563 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT58225 NZ_CP013302:403246-403563 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References