Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 406303..406707 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag GQX72_RS16010 Protein ID WP_001114075.1
Coordinates 406438..406707 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GQX72_RS16005 Protein ID WP_099607150.1
Coordinates 406303..406407 (+) Length 35 a.a.

Genomic Context

GQX72_RS15970GQX72_RS15975GQX72_RS15980GQX72_RS15985GQX72_RS15990GQX72_RS15995GQX72_RS16000GQX72_RS16005GQX72_RS16010GQX72_RS16015GQX72_RS16020GQX72_RS16030GQX72_RS16045GQX72_RS16050GQX72_RS16035GQX72_RS16040
Location: 401804..402721 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 402878..403267 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 403403..403612 (210 bp)
Type: Others
Protein ID: Protein_424
Location: 403731..404168 (438 bp)
Type: Others
Protein ID: WP_000503164.1
Location: 404232..404450 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 404625..405497 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 405647..406246 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 406303..406407 (105 bp)
Type: Antitoxin
Protein ID: WP_099607150.1
Location: 406438..406707 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 406701..407222 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 407521..407646 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 407897..408292 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 409184..409699 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 409883..410296 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 408431..408709 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 408706..408990 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GQX72_RS15970401804..402721+918WP_000186333.1alpha/beta hydrolase-
GQX72_RS15975402878..403267+390WP_001081302.1hypothetical protein-
GQX72_RS15980403403..403612+210Protein_424GNAT family N-acetyltransferase-
GQX72_RS15985403731..404168+438WP_000503164.1IS200/IS605-like element IS1004 family transposase-
GQX72_RS15990404232..404450+219WP_071908318.1GNAT family N-acetyltransferase-
GQX72_RS15995404625..405497+873WP_000254716.1DUF3800 domain-containing protein-
GQX72_RS16000405647..406246+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
GQX72_RS16005406303..406407+105WP_099607150.1acetyltransferaseAntitoxin
GQX72_RS16010406438..406707+270WP_001114075.1DUF4160 domain-containing proteinToxin
GQX72_RS16015406701..407222+522WP_000921691.1DUF2442 domain-containing protein-
GQX72_RS16020407521..407646+126WP_001905700.1DUF645 family protein-
GQX72_RS16030407897..408292+396WP_001000867.1hypothetical protein-
GQX72_RS16035408431..408709-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
GQX72_RS16040408706..408990-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
GQX72_RS16045409184..409699+516WP_000343779.1GNAT family N-acetyltransferase-
GQX72_RS16050409883..410296+414WP_000049420.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-305960..411159105199
insideIntegron--311040..41078399743
flankIS/Tn--403731..404168437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T145407 WP_001114075.1 NZ_CP047060:406438-406707 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T145407 NZ_CP062376:2659379-2659741 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT145407 WP_099607150.1 NZ_CP047060:406303-406407 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT145407 NZ_CP062376:2659212-2659382 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
No matching records found

References