Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | dhiT-phd/- |
Location | 406303..406707 | Replicon | chromosome |
Accession | NZ_CP047060 | ||
Organism | Vibrio cholerae isolate CTMA_1441 |
Toxin (Protein)
Gene name | dhiT | Uniprot ID | A0A086SLD6 |
Locus tag | GQX72_RS16010 | Protein ID | WP_001114075.1 |
Coordinates | 406438..406707 (+) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | - |
Locus tag | GQX72_RS16005 | Protein ID | WP_099607150.1 |
Coordinates | 406303..406407 (+) | Length | 35 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GQX72_RS15970 | 401804..402721 | + | 918 | WP_000186333.1 | alpha/beta hydrolase | - |
GQX72_RS15975 | 402878..403267 | + | 390 | WP_001081302.1 | hypothetical protein | - |
GQX72_RS15980 | 403403..403612 | + | 210 | Protein_424 | GNAT family N-acetyltransferase | - |
GQX72_RS15985 | 403731..404168 | + | 438 | WP_000503164.1 | IS200/IS605-like element IS1004 family transposase | - |
GQX72_RS15990 | 404232..404450 | + | 219 | WP_071908318.1 | GNAT family N-acetyltransferase | - |
GQX72_RS15995 | 404625..405497 | + | 873 | WP_000254716.1 | DUF3800 domain-containing protein | - |
GQX72_RS16000 | 405647..406246 | + | 600 | WP_001891245.1 | glutathione S-transferase N-terminal domain-containing protein | - |
GQX72_RS16005 | 406303..406407 | + | 105 | WP_099607150.1 | acetyltransferase | Antitoxin |
GQX72_RS16010 | 406438..406707 | + | 270 | WP_001114075.1 | DUF4160 domain-containing protein | Toxin |
GQX72_RS16015 | 406701..407222 | + | 522 | WP_000921691.1 | DUF2442 domain-containing protein | - |
GQX72_RS16020 | 407521..407646 | + | 126 | WP_001905700.1 | DUF645 family protein | - |
GQX72_RS16030 | 407897..408292 | + | 396 | WP_001000867.1 | hypothetical protein | - |
GQX72_RS16035 | 408431..408709 | - | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
GQX72_RS16040 | 408706..408990 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
GQX72_RS16045 | 409184..409699 | + | 516 | WP_000343779.1 | GNAT family N-acetyltransferase | - |
GQX72_RS16050 | 409883..410296 | + | 414 | WP_000049420.1 | VOC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 305960..411159 | 105199 | |
inside | Integron | - | - | 311040..410783 | 99743 | ||
flank | IS/Tn | - | - | 403731..404168 | 437 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10310.94 Da Isoelectric Point: 6.6303
>T145407 WP_001114075.1 NZ_CP047060:406438-406707 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
Download Length: 270 bp
>T145407 NZ_CP062376:2659379-2659741 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG
Antitoxin
Download Length: 35 a.a. Molecular weight: 3991.79 Da Isoelectric Point: 9.2853
>AT145407 WP_099607150.1 NZ_CP047060:406303-406407 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL
Download Length: 105 bp
>AT145407 NZ_CP062376:2659212-2659382 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|