145407

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) dhiT-phd/-
Location 406303..406707 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag GQX72_RS16010 Protein ID WP_001114075.1
Coordinates 406438..406707 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GQX72_RS16005 Protein ID WP_099607150.1
Coordinates 406303..406407 (+) Length 35 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX72_RS15970 401804..402721 + 918 WP_000186333.1 alpha/beta hydrolase -
GQX72_RS15975 402878..403267 + 390 WP_001081302.1 hypothetical protein -
GQX72_RS15980 403403..403612 + 210 Protein_424 GNAT family N-acetyltransferase -
GQX72_RS15985 403731..404168 + 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
GQX72_RS15990 404232..404450 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
GQX72_RS15995 404625..405497 + 873 WP_000254716.1 DUF3800 domain-containing protein -
GQX72_RS16000 405647..406246 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GQX72_RS16005 406303..406407 + 105 WP_099607150.1 acetyltransferase Antitoxin
GQX72_RS16010 406438..406707 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
GQX72_RS16015 406701..407222 + 522 WP_000921691.1 DUF2442 domain-containing protein -
GQX72_RS16020 407521..407646 + 126 WP_001905700.1 DUF645 family protein -
GQX72_RS16030 407897..408292 + 396 WP_001000867.1 hypothetical protein -
GQX72_RS16035 408431..408709 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
GQX72_RS16040 408706..408990 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GQX72_RS16045 409184..409699 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
GQX72_RS16050 409883..410296 + 414 WP_000049420.1 VOC family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305960..411159 105199
inside Integron - - 311040..410783 99743
flank IS/Tn - - 403731..404168 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-74)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T145407 WP_001114075.1 NZ_CP047060:406438-406707 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T145407 NZ_CP062376:2659379-2659741 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT145407 WP_099607150.1 NZ_CP047060:406303-406407 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT145407 NZ_CP062376:2659212-2659382 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A086SLD6


Antitoxin

Source ID Structure

References