Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 970665..971298 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag VCD_RS19015 Protein ID WP_000843587.1
Coordinates 970966..971298 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag VCD_RS19010 Protein ID WP_000071008.1
Coordinates 970665..970979 (-) Length 105 a.a.

Genomic Context

VCD_RS18995VCD_RS18965VCD_RS18970VCD_RS18975VCD_RS20710VCD_RS18980VCD_RS18985VCD_RS18990VCD_RS19000VCD_RS19005VCD_RS19010VCD_RS19015VCD_RS20360VCD_RS20365VCD_RS20380VCD_RS21065VCD_RS19025VCD_RS19030VCD_RS19035VCD_RS20385VCD_RS19040VCD_RS20885VCD_RS21070
Location: 968666..969646 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 965719..966006 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 965996..966247 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 966461..966874 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 966949..967092 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 967062..967463 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 967463..968155 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 968292..968598 (307 bp)
Type: Others
Protein ID: Protein_849
Location: 969771..969926 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 970094..970528 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 970665..970979 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 970966..971298 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 971639..971866 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 971815..971928 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 972094..972375 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 972324..972438 (115 bp)
Type: Others
Protein ID: Protein_858
Location: 972495..972872 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 973043..973285 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 973487..973873 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 974082..974253 (172 bp)
Type: Others
Protein ID: Protein_862
Location: 974571..974840 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 975200..975373 (174 bp)
Type: Others
Protein ID: WP_001882305.1
Location: 975654..975857 (204 bp)
Type: Others
Protein ID: WP_001911745.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCD_RS18965965719..966006-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
VCD_RS18970965996..966247-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
VCD_RS18975966461..966874-414WP_000049417.1VOC family protein-
VCD_RS20710966949..967092-144WP_071908341.1DUF3265 domain-containing protein-
VCD_RS18980967062..967463-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
VCD_RS18985967463..968155-693WP_001047169.1GNAT family N-acetyltransferase-
VCD_RS18990968292..968598-307Protein_849CatB-related O-acetyltransferase-
VCD_RS18995968666..969646+981WP_000019370.1IS5-like element ISVch5 family transposase-
VCD_RS19000969771..969926-156WP_000751734.1hypothetical protein-
VCD_RS19005970094..970528-435WP_000256036.1GNAT family N-acetyltransferase-
VCD_RS19010970665..970979-315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
VCD_RS19015970966..971298-333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
VCD_RS20360971639..971866-228WP_001894457.1DUF1289 domain-containing protein-
VCD_RS20365971815..971928-114WP_001889158.1hypothetical protein-
VCD_RS20380972094..972375-282WP_001894453.1DUF1289 domain-containing protein-
VCD_RS21065972324..972438-115Protein_858acetyltransferase-
VCD_RS19025972495..972872-378WP_000411109.1hypothetical protein-
VCD_RS19030973043..973285-243WP_000107461.1hypothetical protein-
VCD_RS19035973487..973873-387WP_000703163.1VOC family protein-
VCD_RS20385974082..974253-172Protein_862DUF645 family protein-
VCD_RS19040974571..974840-270WP_001198131.1hypothetical protein-
VCD_RS20885975200..975373-174WP_001882305.1DUF3709 domain-containing protein-
VCD_RS21070975654..975857-204WP_001911745.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932253..1057432125179
insideIntegron--958376..105059692220
flankIS/Tn--968666..969646980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T23786 WP_000843587.1 NC_012667:c971298-970966 [Vibrio cholerae MJ-1236]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T23786 NC_012667:c971298-970966 [Vibrio cholerae MJ-1236]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT23786 WP_000071008.1 NC_012667:c970979-970665 [Vibrio cholerae MJ-1236]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT23786 NC_012667:c970979-970665 [Vibrio cholerae MJ-1236]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

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Source
ID
Structure
No matching records found

References