Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 871583..872111 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag LZM82_RS17565 Protein ID WP_000221352.1
Coordinates 871821..872111 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag LZM82_RS17560 Protein ID WP_000213183.1
Coordinates 871583..871831 (+) Length 83 a.a.

Genomic Context

LZM82_RS17525LZM82_RS17560LZM82_RS17565LZM82_RS17530LZM82_RS17535LZM82_RS17540LZM82_RS17545LZM82_RS17550LZM82_RS17555LZM82_RS17570LZM82_RS17575LZM82_RS17580LZM82_RS17585LZM82_RS17590LZM82_RS17595LZM82_RS17600LZM82_RS17605LZM82_RS17610LZM82_RS17615
Location: 866622..867086 (465 bp)
Type: Others
Protein ID: WP_000140244.1
Location: 871583..871831 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 871821..872111 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 867186..867584 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 867740..868240 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 868378..868908 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 869059..869454 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 869662..870087 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 870359..871012 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 872247..872708 (462 bp)
Type: Others
Protein ID: WP_001911578.1
Location: 872899..873375 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 873403..873513 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 873510..874439 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 874559..875005 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 875158..876162 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 876350..876466 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 876429..876554 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 876582..876692 (111 bp)
Type: Others
Protein ID: Protein_790
Location: 876731..876841 (111 bp)
Type: Others
Protein ID: WP_134814058.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LZM82_RS17525 (LZM82_17525)866622..867086+465WP_000140244.1hypothetical protein-
LZM82_RS17530 (LZM82_17530)867186..867584-399WP_001882293.1hypothetical protein-
LZM82_RS17535 (LZM82_17535)867740..868240-501WP_000789723.1hypothetical protein-
LZM82_RS17540 (LZM82_17540)868378..868908-531WP_000415563.1hypothetical protein-
LZM82_RS17545 (LZM82_17545)869059..869454-396WP_000649527.1DUF3465 domain-containing protein-
LZM82_RS17550 (LZM82_17550)869662..870087-426WP_000415748.1hypothetical protein-
LZM82_RS17555 (LZM82_17555)870359..871012-654WP_000036957.1site-specific DNA-methyltransferase-
LZM82_RS17560 (LZM82_17560)871583..871831+249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
LZM82_RS17565 (LZM82_17565)871821..872111+291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LZM82_RS17570 (LZM82_17570)872247..872708-462WP_001911578.1lipocalin family protein-
LZM82_RS17575 (LZM82_17575)872899..873375-477WP_001047180.1GNAT family N-acetyltransferase-
LZM82_RS17580 (LZM82_17580)873403..873513-111WP_071917832.1DUF3265 domain-containing protein-
LZM82_RS17585 (LZM82_17585)873510..874439-930WP_000335802.1hypothetical protein-
LZM82_RS17590 (LZM82_17590)874559..875005-447WP_000128977.1hypothetical protein-
LZM82_RS17595 (LZM82_17595)875158..876162-1005WP_000964925.1LD-carboxypeptidase-
LZM82_RS17600 (LZM82_17600)876350..876466-117WP_001889170.1hypothetical protein-
LZM82_RS17605 (LZM82_17605)876429..876554-126WP_001944767.1DUF645 family protein-
LZM82_RS17610 (LZM82_17610)876582..876692-111Protein_790acetyltransferase-
LZM82_RS17615 (LZM82_17615)876731..876841-111WP_134814058.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-835643..943910108267
insideIntegron--836019..937068101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T230643 WP_000221352.1 NZ_CP090400:871821-872111 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T230643 NZ_CP125223:454351-454740 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT230643 WP_000213183.1 NZ_CP090400:871583-871831 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT230643 NZ_CP125223:454087-454344 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References