230643

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 871583..872111 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag LZM82_RS17565 Protein ID WP_000221352.1
Coordinates 871821..872111 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag LZM82_RS17560 Protein ID WP_000213183.1
Coordinates 871583..871831 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZM82_RS17525 (LZM82_17525) 866622..867086 + 465 WP_000140244.1 hypothetical protein -
LZM82_RS17530 (LZM82_17530) 867186..867584 - 399 WP_001882293.1 hypothetical protein -
LZM82_RS17535 (LZM82_17535) 867740..868240 - 501 WP_000789723.1 hypothetical protein -
LZM82_RS17540 (LZM82_17540) 868378..868908 - 531 WP_000415563.1 hypothetical protein -
LZM82_RS17545 (LZM82_17545) 869059..869454 - 396 WP_000649527.1 DUF3465 domain-containing protein -
LZM82_RS17550 (LZM82_17550) 869662..870087 - 426 WP_000415748.1 hypothetical protein -
LZM82_RS17555 (LZM82_17555) 870359..871012 - 654 WP_000036957.1 site-specific DNA-methyltransferase -
LZM82_RS17560 (LZM82_17560) 871583..871831 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LZM82_RS17565 (LZM82_17565) 871821..872111 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZM82_RS17570 (LZM82_17570) 872247..872708 - 462 WP_001911578.1 lipocalin family protein -
LZM82_RS17575 (LZM82_17575) 872899..873375 - 477 WP_001047180.1 GNAT family N-acetyltransferase -
LZM82_RS17580 (LZM82_17580) 873403..873513 - 111 WP_071917832.1 DUF3265 domain-containing protein -
LZM82_RS17585 (LZM82_17585) 873510..874439 - 930 WP_000335802.1 hypothetical protein -
LZM82_RS17590 (LZM82_17590) 874559..875005 - 447 WP_000128977.1 hypothetical protein -
LZM82_RS17595 (LZM82_17595) 875158..876162 - 1005 WP_000964925.1 LD-carboxypeptidase -
LZM82_RS17600 (LZM82_17600) 876350..876466 - 117 WP_001889170.1 hypothetical protein -
LZM82_RS17605 (LZM82_17605) 876429..876554 - 126 WP_001944767.1 DUF645 family protein -
LZM82_RS17610 (LZM82_17610) 876582..876692 - 111 Protein_790 acetyltransferase -
LZM82_RS17615 (LZM82_17615) 876731..876841 - 111 WP_134814058.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 835643..943910 108267
inside Integron - - 836019..937068 101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T230643 WP_000221352.1 NZ_CP090400:871821-872111 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T230643 NZ_CP125223:454351-454740 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT230643 WP_000213183.1 NZ_CP090400:871583-871831 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT230643 NZ_CP125223:454087-454344 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References