293826

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 349626..350164 Replicon chromosome
Accession NZ_LT907990
Organism Vibrio cholerae strain A19

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag ALC86_RS15700 Protein ID WP_000802136.1
Coordinates 349626..349925 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag ALC86_RS15705 Protein ID WP_001107719.1
Coordinates 349922..350164 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ALC86_RS15650 345561..345743 + 183 WP_000923182.1 DUF645 family protein -
ALC86_RS15655 345943..346416 + 474 WP_001161076.1 GrpB family protein -
ALC86_RS15660 346431..346523 + 93 WP_014378730.1 DUF3265 domain-containing protein -
ALC86_RS15665 346565..347191 + 627 WP_000365424.1 LysE family translocator -
ALC86_RS15670 347314..348012 + 699 WP_001890502.1 hypothetical protein -
ALC86_RS15675 348022..348132 + 111 WP_079857360.1 DUF3265 domain-containing protein -
ALC86_RS15690 348710..348889 + 180 WP_001883058.1 DUF645 family protein -
ALC86_RS15695 349103..349498 + 396 WP_000870857.1 DUF3465 domain-containing protein -
ALC86_RS15700 349626..349925 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ALC86_RS15705 349922..350164 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
ALC86_RS15710 350393..350971 + 579 WP_000110120.1 hypothetical protein -
ALC86_RS15715 350993..351085 + 93 WP_014164112.1 DUF3265 domain-containing protein -
ALC86_RS15725 351509..352192 + 684 WP_000877436.1 hypothetical protein -
ALC86_RS15730 352406..352672 + 267 WP_000937852.1 hypothetical protein -
ALC86_RS15740 352827..353425 + 599 Protein_338 hypothetical protein -
ALC86_RS15745 353706..354641 + 936 WP_000051985.1 restriction endonuclease -
ALC86_RS15750 354607..354747 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304666..435761 131095
inside Integron catB9 - 309746..435385 125639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T293826 WP_000802136.1 NZ_LT907990:c349925-349626 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT293826 WP_001107719.1 NZ_LT907990:c350164-349922 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References