Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 432030..432814 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag GTF74_RS16160 Protein ID WP_001114075.1
Coordinates 432030..432299 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag GTF74_RS16165 Protein ID WP_000921691.1
Coordinates 432293..432814 (+) Length 174 a.a.

Genomic Context

GTF74_RS16120GTF74_RS16125GTF74_RS16130GTF74_RS16135GTF74_RS16140GTF74_RS16145GTF74_RS16150GTF74_RS16155GTF74_RS16160GTF74_RS16165GTF74_RS16170GTF74_RS16175GTF74_RS16190GTF74_RS16195GTF74_RS16200GTF74_RS16210GTF74_RS16180GTF74_RS16185GTF74_RS16205
Location: 427396..428313 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 428470..428859 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 428995..429204 (210 bp)
Type: Others
Protein ID: Protein_472
Location: 429323..429760 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 429824..430042 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 430217..431089 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 431239..431838 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 431895..431999 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 432030..432299 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 432293..432814 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 433113..433238 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 433489..433884 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 434776..435291 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 435348..435443 (96 bp)
Type: Others
Protein ID: WP_099607151.1
Location: 435475..435888 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 436443..437620 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 434023..434301 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 434298..434582 (285 bp)
Type: Others
Protein ID: WP_000381183.1
Location: 435895..436027 (133 bp)
Type: Others
Protein ID: Protein_487
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF74_RS16120427396..428313+918WP_000186333.1alpha/beta hydrolase-
GTF74_RS16125428470..428859+390WP_001081302.1hypothetical protein-
GTF74_RS16130428995..429204+210Protein_472GNAT family N-acetyltransferase-
GTF74_RS16135429323..429760+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
GTF74_RS16140429824..430042+219WP_071908318.1GNAT family N-acetyltransferase-
GTF74_RS16145430217..431089+873WP_000254716.1DUF3800 domain-containing protein-
GTF74_RS16150431239..431838+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
GTF74_RS16155431895..431999+105WP_099607150.1acetyltransferase-
GTF74_RS16160432030..432299+270WP_001114075.1DUF4160 domain-containing proteinToxin
GTF74_RS16165432293..432814+522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
GTF74_RS16170433113..433238+126WP_001905700.1DUF645 family protein-
GTF74_RS16175433489..433884+396WP_001000867.1hypothetical protein-
GTF74_RS16180434023..434301-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
GTF74_RS16185434298..434582-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
GTF74_RS16190434776..435291+516WP_000343779.1GNAT family N-acetyltransferase-
GTF74_RS16195435348..435443+96WP_099607151.1acetyltransferase-
GTF74_RS16200435475..435888+414WP_000049420.1VOC family protein-
GTF74_RS16205435895..436027-133Protein_487hypothetical protein-
GTF74_RS16210436443..437620+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-307032..436751129719
insideIntegron--312112..436375124263
flankIS/Tn--429323..429760437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T145900 WP_001114075.1 NZ_CP047304:432030-432299 [Vibrio cholerae O1 biovar El Tor]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T145900 NZ_CP062708:947785-948192 [Escherichia coli O157:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT145900 WP_000921691.1 NZ_CP047304:432293-432814 [Vibrio cholerae O1 biovar El Tor]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT145900 NZ_CP062708:947538-947804 [Escherichia coli O157:H7]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References