Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 936617..937401 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag K1T75_RS17805 Protein ID WP_001114075.1
Coordinates 937132..937401 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag K1T75_RS17800 Protein ID WP_000921691.1
Coordinates 936617..937138 (-) Length 174 a.a.

Genomic Context

K1T75_RS17780K1T75_RS17785K1T75_RS17770K1T75_RS17775K1T75_RS17790K1T75_RS17795K1T75_RS17800K1T75_RS17805K1T75_RS17810K1T75_RS17815K1T75_RS17820K1T75_RS17825K1T75_RS17830K1T75_RS17835K1T75_RS17840K1T75_RS17845
Location: 934849..935133 (285 bp)
Type: Others
Protein ID: WP_000381183.1
Location: 935130..935408 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 933543..933956 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 934140..934655 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 935547..935942 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 936193..936318 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 936617..937138 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 937132..937401 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 937468..937536 (69 bp)
Type: Others
Protein ID: Protein_805
Location: 937593..938192 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 938342..939214 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 939389..939610 (222 bp)
Type: Others
Protein ID: Protein_808
Location: 939671..940108 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 940227..940436 (210 bp)
Type: Others
Protein ID: Protein_810
Location: 940572..940961 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 941118..942035 (918 bp)
Type: Others
Protein ID: WP_000186333.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K1T75_RS17770933543..933956-414WP_000049420.1VOC family protein-
K1T75_RS17775934140..934655-516WP_000343779.1GNAT family protein-
K1T75_RS17780934849..935133+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
K1T75_RS17785935130..935408+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
K1T75_RS17790935547..935942-396WP_001000867.1hypothetical protein-
K1T75_RS17795936193..936318-126WP_001905700.1DUF645 family protein-
K1T75_RS17800936617..937138-522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
K1T75_RS17805937132..937401-270WP_001114075.1DUF4160 domain-containing proteinToxin
K1T75_RS17810937468..937536-69Protein_805acetyltransferase-
K1T75_RS17815937593..938192-600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
K1T75_RS17820938342..939214-873WP_000254716.1DUF3800 domain-containing protein-
K1T75_RS17825939389..939610-222Protein_808GNAT family N-acetyltransferase-
K1T75_RS17830939671..940108-438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
K1T75_RS17835940227..940436-210Protein_810GNAT family N-acetyltransferase-
K1T75_RS17840940572..940961-390WP_001081302.1hypothetical protein-
K1T75_RS17845941118..942035-918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932680..1039634106954
insideIntegron--933056..103279299736
flankIS/Tn--939671..940108437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T211907 WP_001114075.1 NZ_CP080466:c937401-937132 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T211907 NZ_CP106838:c2117912-2117604 [Klebsiella michiganensis]
ATGCAGTATTACGTATATAAGAATACAGGTCGAATTGCTGCGTATCCTTACCTCCTTGATGTACAGAGTGACATTATCGG
CAAGCGCAATACTCGGGTCGTGATTCCACTGTTTCCACTGAAAAACTATAAAGGTCCACGCGCCGATCGTTTAACACCGC
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGCATCCCACATCGTGTTCTGGGTGAAGAG
GTTTGTAATCTGAATCACCAGCTCGAAGTCGTTAAAGCTTCAATGGATTTTCTTTTCGACGGGATCTAA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT211907 WP_000921691.1 NZ_CP080466:c937138-936617 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT211907 NZ_CP106838:c2118151-2117915 [Klebsiella michiganensis]
ATGCCAGCCGCAAAACGCAATAAGCAGAACGTCAGCGTGACACTGGACCCAGGCCTGGTCAAACAGGCTCGTGAGGTCGG
CATCAATCTGTCTCTAACGTTGACTAACGCTCTAAAAAGCGAAATCCACAGCCTCGAAATAGCCCGCTGGCAAAAAGAAA
ATGCCCAGGCAATCGACTACCTCAATAATTTAACTGAGGAAAATGGACTTCTCTCTGATGAATACAGGACGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References