293833

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 421785..422551 Replicon chromosome
Accession NZ_LT907990
Organism Vibrio cholerae strain A19

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ALC86_RS16470 Protein ID WP_000982260.1
Coordinates 421785..422282 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ALC86_RS16475 Protein ID WP_000246253.1
Coordinates 422279..422551 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ALC86_RS16415 417647..417953 + 307 Protein_446 CatB-related O-acetyltransferase -
ALC86_RS16420 418090..418782 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
ALC86_RS16425 418782..419183 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
ALC86_RS16430 419153..419296 + 144 WP_071908341.1 DUF3265 domain-containing protein -
ALC86_RS16435 419371..419784 + 414 WP_000049417.1 VOC family protein -
ALC86_RS16440 419998..420249 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ALC86_RS16445 420239..420526 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
ALC86_RS16450 420654..421109 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
ALC86_RS16460 421431..421583 + 153 WP_001884520.1 DUF645 family protein -
ALC86_RS16470 421785..422282 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
ALC86_RS16475 422279..422551 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
ALC86_RS16485 422782..423450 + 669 WP_000043871.1 hypothetical protein -
ALC86_RS16490 423602..423889 + 288 WP_000426470.1 hypothetical protein -
ALC86_RS16495 424030..424401 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
ALC86_RS19780 424468..424893 + 426 WP_001882332.1 DUF1778 domain-containing protein -
ALC86_RS16505 424890..425423 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
ALC86_RS16515 425625..425882 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ALC86_RS16520 425870..426172 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
ALC86_RS16525 426406..427323 + 918 WP_000186333.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304666..435761 131095
inside Integron catB9 - 309746..435385 125639
flank IS/Tn - - 416599..417579 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T293833 WP_000982260.1 NZ_LT907990:c422282-421785 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT293833 WP_000246253.1 NZ_LT907990:c422551-422279 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References