198991

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 425038..425837 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag J9265_RS16070 Protein ID WP_000118351.1
Coordinates 425304..425837 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0K9UER4
Locus tag J9265_RS19190 Protein ID WP_000179600.1
Coordinates 425038..425307 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9265_RS16020 (J9265_16020) 420412..420663 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
J9265_RS16025 (J9265_16025) 420653..420940 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
J9265_RS16030 (J9265_16030) 421068..421523 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
J9265_RS19175 421580..421702 + 123 Protein_480 acetyltransferase -
J9265_RS16035 (J9265_16035) 421873..421997 + 125 Protein_481 DUF645 family protein -
J9265_RS19180 422114..422182 + 69 Protein_482 acetyltransferase -
J9265_RS16040 (J9265_16040) 422199..422696 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
J9265_RS16045 (J9265_16045) 422693..422965 - 273 WP_000246253.1 DUF1778 domain-containing protein -
J9265_RS19185 423117..423179 + 63 Protein_485 acetyltransferase -
J9265_RS16050 (J9265_16050) 423196..423864 + 669 WP_000043871.1 hypothetical protein -
J9265_RS16055 (J9265_16055) 424016..424303 + 288 WP_000426470.1 hypothetical protein -
J9265_RS16060 (J9265_16060) 424444..424815 + 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
J9265_RS19190 425038..425307 + 270 WP_000179600.1 DUF1778 domain-containing protein Antitoxin
J9265_RS16070 (J9265_16070) 425304..425837 + 534 WP_000118351.1 GNAT family N-acetyltransferase Toxin
J9265_RS19195 425847..425957 + 111 WP_086010065.1 DUF3265 domain-containing protein -
J9265_RS16075 (J9265_16075) 426039..426296 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
J9265_RS16080 (J9265_16080) 426284..426586 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
J9265_RS16085 (J9265_16085) 426820..427737 + 918 WP_000186333.1 alpha/beta hydrolase -
J9265_RS16090 (J9265_16090) 427894..428283 + 390 WP_001081302.1 hypothetical protein -
J9265_RS16095 (J9265_16095) 428419..428628 + 210 Protein_496 GNAT family N-acetyltransferase -
J9265_RS16100 (J9265_16100) 428747..429184 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
J9265_RS16105 (J9265_16105) 429245..429466 + 222 Protein_498 GNAT family N-acetyltransferase -
J9265_RS16110 (J9265_16110) 429641..430513 + 873 WP_000254716.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805
flank IS/Tn - - 428747..429184 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T198991 WP_000118351.1 NZ_CP072848:425304-425837 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T198991 NZ_CP097082:811635-812045 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9924.49 Da        Isoelectric Point: 4.9107

>AT198991 WP_000179600.1 NZ_CP072848:425038-425307 [Vibrio cholerae]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAV
KFTEKSGIK

Download         Length: 270 bp

>AT198991 NZ_CP097082:811388-811654 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM94

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UER4

References