230639

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 848853..849619 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag LZM82_RS17340 Protein ID WP_000982260.1
Coordinates 849122..849619 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag LZM82_RS17335 Protein ID WP_000246253.1
Coordinates 848853..849125 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZM82_RS17285 (LZM82_17285) 844081..844998 - 918 WP_000186333.1 alpha/beta hydrolase -
LZM82_RS17290 (LZM82_17290) 845232..845534 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZM82_RS17295 (LZM82_17295) 845522..845779 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LZM82_RS17300 (LZM82_17300) 845861..845971 - 111 WP_086010065.1 DUF3265 domain-containing protein -
LZM82_RS17305 (LZM82_17305) 845981..846514 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
LZM82_RS17310 (LZM82_17310) 846511..846780 - 270 WP_000179600.1 DUF1778 domain-containing protein -
LZM82_RS17315 (LZM82_17315) 847003..847374 - 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
LZM82_RS17320 (LZM82_17320) 847515..847802 - 288 WP_000426470.1 hypothetical protein -
LZM82_RS17325 (LZM82_17325) 847954..848622 - 669 WP_000043871.1 hypothetical protein -
LZM82_RS17330 (LZM82_17330) 848639..848701 - 63 Protein_733 acetyltransferase -
LZM82_RS17335 (LZM82_17335) 848853..849125 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
LZM82_RS17340 (LZM82_17340) 849122..849619 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
LZM82_RS17345 (LZM82_17345) 849636..849704 - 69 Protein_736 acetyltransferase -
LZM82_RS17350 (LZM82_17350) 849821..849925 - 105 WP_228840819.1 DUF645 family protein -
LZM82_RS17360 (LZM82_17360) 850116..850238 - 123 Protein_738 acetyltransferase -
LZM82_RS17365 (LZM82_17365) 850295..850750 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
LZM82_RS17370 (LZM82_17370) 850878..851165 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZM82_RS17375 (LZM82_17375) 851155..851406 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LZM82_RS17380 (LZM82_17380) 851620..852033 - 414 WP_000049417.1 VOC family protein -
LZM82_RS17385 (LZM82_17385) 852108..852218 - 111 WP_082798255.1 DUF3265 domain-containing protein -
LZM82_RS17390 (LZM82_17390) 852221..852622 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
LZM82_RS17395 (LZM82_17395) 852622..852792 - 171 WP_001080654.1 hypothetical protein -
LZM82_RS17400 (LZM82_17400) 852916..853314 - 399 Protein_746 GNAT family N-acetyltransferase -
LZM82_RS17405 (LZM82_17405) 853451..853757 - 307 Protein_747 CatB-related O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 835643..943910 108267
inside Integron - - 836019..937068 101049
flank IS/Tn - - 853825..854805 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T230639 WP_000982260.1 NZ_CP090400:849122-849619 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T230639 NZ_CP125220:c4489047-4488736 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT230639 WP_000246253.1 NZ_CP090400:848853-849125 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT230639 NZ_CP125220:c4488735-4488445 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References