Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 119871..120964 Replicon chromosome
Accession NZ_CP007635
Organism Vibrio cholerae strain 2012EL-2176

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag EN18_RS14940 Protein ID WP_000351248.1
Coordinates 120563..120964 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag EN18_RS14935 Protein ID WP_001047169.1
Coordinates 119871..120563 (+) Length 231 a.a.

Genomic Context

EN18_RS14895EN18_RS21575EN18_RS20695EN18_RS20710EN18_RS20715EN18_RS14905EN18_RS14910EN18_RS14915EN18_RS21395EN18_RS14930EN18_RS14935EN18_RS14940EN18_RS21220EN18_RS14945EN18_RS14950EN18_RS14955EN18_RS14960EN18_RS14965EN18_RS14980EN18_RS14985EN18_RS14925EN18_RS14970EN18_RS14975
Location: 115154..115531 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 115588..115702 (115 bp)
Type: Others
Protein ID: Protein_174
Location: 115651..115932 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 116098..116211 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 116160..116387 (228 bp)
Type: Others
Protein ID: WP_073426587.1
Location: 116728..117060 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 117047..117361 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 117498..117932 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 118100..118255 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 119428..119734 (307 bp)
Type: Others
Protein ID: Protein_183
Location: 119871..120563 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 120563..120964 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 120934..121077 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 121152..121565 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 121779..122030 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 122020..122307 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 122435..122890 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 123212..123364 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 124563..125231 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 125383..125670 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 118380..119360 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 123566..124063 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 124060..124332 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EN18_RS14895115154..115531+378WP_000411109.1hypothetical protein-
EN18_RS21575115588..115702+115Protein_174acetyltransferase-
EN18_RS20695115651..115932+282WP_001894453.1DUF1289 domain-containing protein-
EN18_RS20710116098..116211+114WP_001889158.1hypothetical protein-
EN18_RS20715116160..116387+228WP_073426587.1DUF1289 domain-containing protein-
EN18_RS14905116728..117060+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
EN18_RS14910117047..117361+315WP_000071008.1DNA-binding transcriptional regulator-
EN18_RS14915117498..117932+435WP_000256036.1GNAT family N-acetyltransferase-
EN18_RS21395118100..118255+156WP_000751734.1hypothetical protein-
EN18_RS14925118380..119360-981WP_000019370.1IS5-like element ISVch5 family transposase-
EN18_RS14930119428..119734+307Protein_183CatB-related O-acetyltransferase-
EN18_RS14935119871..120563+693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
EN18_RS14940120563..120964+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
EN18_RS21220120934..121077+144WP_071908341.1DUF3265 domain-containing protein-
EN18_RS14945121152..121565+414WP_000049417.1VOC family protein-
EN18_RS14950121779..122030+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
EN18_RS14955122020..122307+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
EN18_RS14960122435..122890+456WP_001245327.1GNAT family N-acetyltransferase-
EN18_RS14965123212..123364+153WP_001884520.1DUF645 family protein-
EN18_RS14970123566..124063-498WP_000982260.1GNAT family N-acetyltransferase-
EN18_RS14975124060..124332-273WP_000246253.1DUF1778 domain-containing protein-
EN18_RS14980124563..125231+669WP_000043871.1hypothetical protein-
EN18_RS14985125383..125670+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31037..137542106505
insideIntegron--36117..137166101049
flankIS/Tn--118380..119360980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T46759 WP_000351248.1 NZ_CP007635:120563-120964 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T46759 NZ_CP007635:120563-120964 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT46759 WP_001047169.1 NZ_CP007635:119871-120563 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT46759 NZ_CP007635:119871-120563 [Vibrio cholerae]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTTGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATGCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTTTTTTATCACGTTTT
GGGGCTATAATCGGCCTAACCTTTATTGATAGTAGGTGTGATATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGT
TGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGACTGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTA
AACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGGCTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References