Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 431250..431809 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag VCA1552_RS16915 Protein ID WP_000578476.1
Coordinates 431250..431528 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag VCA1552_RS16920 Protein ID WP_000381183.1
Coordinates 431525..431809 (-) Length 95 a.a.

Genomic Context

VCA1552_RS16865VCA1552_RS16870VCA1552_RS16875VCA1552_RS16880VCA1552_RS16885VCA1552_RS16890VCA1552_RS16895VCA1552_RS16900VCA1552_RS16910VCA1552_RS16925VCA1552_RS16935VCA1552_RS16950VCA1552_RS16915VCA1552_RS16920
Location: 426550..426987 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 427051..427269 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 427444..428316 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 428466..429065 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 429122..429226 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 429257..429526 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 429520..430041 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 430340..430465 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 430716..431111 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 432003..432518 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 432702..433115 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 433670..434847 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 431250..431528 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 431525..431809 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCA1552_RS16865426550..426987+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
VCA1552_RS16870427051..427269+219WP_071908318.1GNAT family N-acetyltransferase-
VCA1552_RS16875427444..428316+873WP_000254716.1DUF3800 domain-containing protein-
VCA1552_RS16880428466..429065+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
VCA1552_RS16885429122..429226+105WP_099607150.1acetyltransferase-
VCA1552_RS16890429257..429526+270WP_001114075.1DUF4160 domain-containing protein-
VCA1552_RS16895429520..430041+522WP_000921691.1DUF2442 domain-containing protein-
VCA1552_RS16900430340..430465+126WP_001905700.1DUF645 family protein-
VCA1552_RS16910430716..431111+396WP_001000867.1hypothetical protein-
VCA1552_RS16915431250..431528-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
VCA1552_RS16920431525..431809-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
VCA1552_RS16925432003..432518+516WP_000343779.1GNAT family N-acetyltransferase-
VCA1552_RS16935432702..433115+414WP_000049420.1VOC family protein-
VCA1552_RS16950433670..434847+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304717..433978129261
insideIntegron--309797..433602123805
flankIS/Tn--426550..426987437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T89004 WP_000578476.1 NZ_CP024868:c431528-431250 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T89004 NZ_CP024868:c431528-431250 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT89004 WP_000381183.1 NZ_CP024868:c431809-431525 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT89004 NZ_CP024868:c431809-431525 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References