Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 371735..372350 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag N16961_RS16020 Protein ID WP_001162670.1
Coordinates 371735..372022 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N16961_RS16025 Protein ID WP_001232701.1
Coordinates 372033..372350 (+) Length 106 a.a.

Genomic Context

N16961_RS19920N16961_RS15990N16961_RS15995N16961_RS16000N16961_RS16005N16961_RS16010N16961_RS16020N16961_RS16025N16961_RS19925N16961_RS19835N16961_RS19840N16961_RS16050N16961_RS16055N16961_RS16060N16961_RS16070N16961_RS16075N16961_RS15980N16961_RS15985
Location: 367371..367466 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 368480..368989 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 369046..369699 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 370009..370227 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 370630..370863 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 371288..371468 (181 bp)
Type: Others
Protein ID: Protein_365
Location: 371735..372022 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 372033..372350 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 372347..372457 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 372634..372759 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 372775..372813 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 373037..373777 (741 bp)
Type: Others
Protein ID: WP_000469836.1
Location: 373982..374812 (831 bp)
Type: Others
Protein ID: WP_000056616.1
Location: 374869..375351 (483 bp)
Type: Others
Protein ID: WP_001895003.1
Location: 375798..376673 (876 bp)
Type: Others
Protein ID: WP_000259044.1
Location: 376803..377258 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 367660..367977 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 367996..368238 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N16961_RS19920367371..367466+96WP_001907607.1DUF645 family protein-
N16961_RS15980367660..367977-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
N16961_RS15985367996..368238-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
N16961_RS15990368480..368989+510WP_000405987.1GNAT family N-acetyltransferase-
N16961_RS15995369046..369699+654WP_000226874.1hypothetical protein-
N16961_RS16000370009..370227+219WP_001917086.1DUF3709 domain-containing protein-
N16961_RS16005370630..370863+234WP_032482776.1DUF3709 domain-containing protein-
N16961_RS16010371288..371468+181Protein_365DUF645 family protein-
N16961_RS16020371735..372022+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
N16961_RS16025372033..372350+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
N16961_RS19925372347..372457+111WP_134814058.1DUF3265 domain-containing protein-
N16961_RS19835372634..372759+126WP_001944767.1DUF645 family protein-
N16961_RS19840372775..372813+39WP_106019119.1hypothetical protein-
N16961_RS16050373037..373777+741WP_000469836.1PhzF family phenazine biosynthesis protein-
N16961_RS16055373982..374812+831WP_000056616.1abortive infection family protein-
N16961_RS16060374869..375351+483WP_001895003.1hypothetical protein-
N16961_RS16070375798..376673+876WP_000259044.1hypothetical protein-
N16961_RS16075376803..377258+456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306977..438073131096
insideIntegron--312057..437697125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T104254 WP_001162670.1 NZ_CP028828:371735-372022 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T104254 NZ_CP028828:371735-372022 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT104254 WP_001232701.1 NZ_CP028828:372033-372350 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT104254 NZ_CP028828:372033-372350 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References