45805

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 333863..334361 Replicon chromosome
Accession NZ_CP006948
Organism Vibrio cholerae O1 str. KW3

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag N900_RS15555 Protein ID WP_000589156.1
Coordinates 333863..334129 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag N900_RS15560 Protein ID WP_000643598.1
Coordinates 334116..334361 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N900_RS19930 329285..329491 + 207 Protein_291 DUF3709 domain-containing protein -
N900_RS19935 329691..329792 + 102 WP_001921603.1 hypothetical protein -
N900_RS15525 329782..330168 + 387 WP_000703163.1 VOC family protein -
N900_RS15530 330363..330614 + 252 WP_001890111.1 TIGR03643 family protein -
N900_RS19445 330587..330736 + 150 WP_071908333.1 DUF3265 domain-containing protein -
N900_RS15535 330828..331070 + 243 WP_000107461.1 hypothetical protein -
N900_RS19450 331214..331599 + 386 Protein_297 DUF3709 domain-containing protein -
N900_RS20340 331974..332117 + 144 Protein_298 DUF645 family protein -
N900_RS20345 332171..332209 + 39 WP_082798268.1 hypothetical protein -
N900_RS15545 332421..332888 + 468 WP_001289288.1 OsmC family protein -
N900_RS15550 333016..333678 + 663 WP_000960654.1 hypothetical protein -
N900_RS15555 333863..334129 + 267 WP_000589156.1 BrnT family toxin Toxin
N900_RS15560 334116..334361 + 246 WP_000643598.1 hypothetical protein Antitoxin
N900_RS15565 334457..335251 + 795 WP_001911581.1 hypothetical protein -
N900_RS15570 335542..335724 + 183 WP_000923182.1 DUF645 family protein -
N900_RS15575 335938..336942 + 1005 WP_000964920.1 LD-carboxypeptidase -
N900_RS15580 337095..337454 + 360 WP_001071541.1 VOC family protein -
N900_RS15585 337727..337960 + 234 WP_001890112.1 DUF3709 domain-containing protein -
N900_RS15590 338228..338734 + 507 WP_000393074.1 hypothetical protein -
N900_RS15595 338891..339277 + 387 WP_000703163.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..411088 106443
inside Integron - - 309725..410760 101035


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T45805 WP_000589156.1 NZ_CP006948:333863-334129 [Vibrio cholerae O1 str. KW3]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T45805 NZ_CP006948:333863-334129 [Vibrio cholerae O1 str. KW3]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT45805 WP_000643598.1 NZ_CP006948:334116-334361 [Vibrio cholerae O1 str. KW3]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT45805 NZ_CP006948:334116-334361 [Vibrio cholerae O1 str. KW3]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References