Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 333863..334361 Replicon chromosome
Accession NZ_CP006948
Organism Vibrio cholerae O1 str. KW3

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag N900_RS15555 Protein ID WP_000589156.1
Coordinates 333863..334129 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag N900_RS15560 Protein ID WP_000643598.1
Coordinates 334116..334361 (+) Length 82 a.a.

Genomic Context

N900_RS19930N900_RS19935N900_RS15525N900_RS15530N900_RS19445N900_RS15535N900_RS19450N900_RS20340N900_RS20345N900_RS15545N900_RS15550N900_RS15555N900_RS15560N900_RS15565N900_RS15570N900_RS15575N900_RS15580N900_RS15585N900_RS15590N900_RS15595
Location: 329285..329491 (207 bp)
Type: Others
Protein ID: Protein_291
Location: 329691..329792 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 329782..330168 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 330363..330614 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 330587..330736 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 330828..331070 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 331214..331599 (386 bp)
Type: Others
Protein ID: Protein_297
Location: 331974..332117 (144 bp)
Type: Others
Protein ID: Protein_298
Location: 332171..332209 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 332421..332888 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 333016..333678 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 333863..334129 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 334116..334361 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 334457..335251 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 335542..335724 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 335938..336942 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 337095..337454 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 337727..337960 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 338228..338734 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 338891..339277 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N900_RS19930329285..329491+207Protein_291DUF3709 domain-containing protein-
N900_RS19935329691..329792+102WP_001921603.1hypothetical protein-
N900_RS15525329782..330168+387WP_000703163.1VOC family protein-
N900_RS15530330363..330614+252WP_001890111.1TIGR03643 family protein-
N900_RS19445330587..330736+150WP_071908333.1DUF3265 domain-containing protein-
N900_RS15535330828..331070+243WP_000107461.1hypothetical protein-
N900_RS19450331214..331599+386Protein_297DUF3709 domain-containing protein-
N900_RS20340331974..332117+144Protein_298DUF645 family protein-
N900_RS20345332171..332209+39WP_082798268.1hypothetical protein-
N900_RS15545332421..332888+468WP_001289288.1OsmC family protein-
N900_RS15550333016..333678+663WP_000960654.1hypothetical protein-
N900_RS15555333863..334129+267WP_000589156.1BrnT family toxinToxin
N900_RS15560334116..334361+246WP_000643598.1hypothetical proteinAntitoxin
N900_RS15565334457..335251+795WP_001911581.1hypothetical protein-
N900_RS15570335542..335724+183WP_000923182.1DUF645 family protein-
N900_RS15575335938..336942+1005WP_000964920.1LD-carboxypeptidase-
N900_RS15580337095..337454+360WP_001071541.1VOC family protein-
N900_RS15585337727..337960+234WP_001890112.1DUF3709 domain-containing protein-
N900_RS15590338228..338734+507WP_000393074.1hypothetical protein-
N900_RS15595338891..339277+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..411088106443
insideIntegron--309725..410760101035


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T45805 WP_000589156.1 NZ_CP006948:333863-334129 [Vibrio cholerae O1 str. KW3]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T45805 NZ_CP006948:333863-334129 [Vibrio cholerae O1 str. KW3]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT45805 WP_000643598.1 NZ_CP006948:334116-334361 [Vibrio cholerae O1 str. KW3]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT45805 NZ_CP006948:334116-334361 [Vibrio cholerae O1 str. KW3]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References