Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) parDE/RHH-RelE
Location 2203681..2204225 Replicon chromosome
Accession NC_000962
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name parE Uniprot ID P9WHG7
Locus tag Rv1959c Protein ID NP_216475.1
Coordinates 2203681..2203977 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WIJ7
Locus tag Rv1960c Protein ID NP_216476.1
Coordinates 2203974..2204225 (-) Length 84 a.a.

Genomic Context

Rv1952Rv1953Rv1955Rv1956Rv1957Rv1961Rv1964Rv1948cRv1950cRv1951cRv1954cRv1958cRv1959cRv1960cRv1962cRv1962ARv1963c
Location: 2200726..2200941 (216 bp)
Type: Others
Protein ID: NP_216468.1
Location: 2200938..2201249 (312 bp)
Type: Others
Protein ID: NP_216469.1
Location: 2201719..2202096 (378 bp)
Type: Others
Protein ID: NP_216471.2
Location: 2202138..2202587 (450 bp)
Type: Others
Protein ID: NP_216472.1
Location: 2202584..2203129 (546 bp)
Type: Others
Protein ID: NP_216473.1
Location: 2204212..2204706 (495 bp)
Type: Others
Protein ID: NP_216477.1
Location: 2207700..2208497 (798 bp)
Type: Others
Protein ID: NP_216480.1
Location: 2198714..2199064 (351 bp)
Type: Others
Protein ID: NP_216464.1
Location: 2199998..2200189 (192 bp)
Type: Others
Protein ID: NP_216466.1
Location: 2200190..2200486 (297 bp)
Type: Others
Protein ID: NP_216467.1
Location: 2201223..2201744 (522 bp)
Type: Others
Protein ID: NP_216470.1
Location: 2203018..2203632 (615 bp)
Type: Others
Protein ID: NP_216474.1
Location: 2203681..2203977 (297 bp)
Type: Toxin
Protein ID: NP_216475.1
Location: 2203974..2204225 (252 bp)
Type: Antitoxin
Protein ID: NP_216476.1
Location: 2204866..2205273 (408 bp)
Type: Others
Protein ID: NP_216478.1
Location: 2205277..2205549 (273 bp)
Type: Others
Protein ID: YP_007410641.1
Location: 2205582..2206802 (1221 bp)
Type: Others
Protein ID: NP_216479.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Rv1948c2198714..2199064-351NP_216464.1hypothetical protein-
Rv1950c2199998..2200189-192NP_216466.1hypothetical protein-
Rv1951c2200190..2200486-297NP_216467.1hypothetical protein-
Rv19522200726..2200941+216NP_216468.1antitoxin VapB14-
Rv19532200938..2201249+312NP_216469.1ribonuclease VapC14-
Rv1954c2201223..2201744-522NP_216470.1hypothetical protein-
Rv19552201719..2202096+378NP_216471.2toxin HigB-
Rv19562202138..2202587+450NP_216472.1antitoxin HigA-
Rv19572202584..2203129+546NP_216473.1SecB-like chaperone-
Rv1958c2203018..2203632-615NP_216474.1hypothetical protein-
Rv1959c2203681..2203977-297NP_216475.1toxin ParE1Toxin
Rv1960c2203974..2204225-252NP_216476.1antitoxin ParD1Antitoxin
Rv19612204212..2204706+495NP_216477.1hypothetical protein-
Rv1962c2204866..2205273-408NP_216478.1ribonuclease VapC35-
Rv1962A2205277..2205549-273YP_007410641.1antitoxin VapB35-
Rv1963c2205582..2206802-1221NP_216479.1transcriptional repressor Mce3R-
Rv19642207700..2208497+798NP_216480.1integral membrane protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T105 NP_216475.1 NC_000962:c2203977-2203681 [Mycobacterium tuberculosis H37Rv]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T105 NC_000962:c2203977-2203681 [Mycobacterium tuberculosis H37Rv]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT105 NP_216476.1 NC_000962:c2204225-2203974 [Mycobacterium tuberculosis H37Rv]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT105 NC_000962:c2204225-2203974 [Mycobacterium tuberculosis H37Rv]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T169Vibrio cholerae O1 biovar El Tor str. N16961

46.154

92.857

0.429

T228Caulobacter crescentus CB15

43.617

97.917

0.427

T10079Pseudoalteromonas rubra strain SCSIO 6842

36.735

100

0.367

T233Caulobacter crescentus CB15

37.079

90.816

0.337
Showing 1 to 4 of 4 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT228Caulobacter crescentus CB15

59.259

97.59

0.578

AT169Vibrio cholerae O1 biovar El Tor str. N16961

54.795

91.25

0.5

AT10079Pseudoalteromonas rubra strain SCSIO 6842

43.243

89.157

0.386
Showing 1 to 3 of 3 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
AlphaFold DBP9WHG7

Antitoxin

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Source
ID
Structure
AlphaFold DBP9WIJ7

References

(1) Amita Gupta (2009) Killing activity and rescue function of genome-wide toxin-antitoxin loci of Mycobacterium tuberculosis. FEMS Microbiology Letters 290(1):45-53. [PubMed:19016878] experimental


experimental experimental literature