Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) parDE/RHH-RelE
Location 3202309..3202882 Replicon chromosome
Accession NC_002696
Organism Caulobacter crescentus CB15

Toxin (Protein)


Gene name parE Uniprot ID A0A0H3CBC5
Locus tag CC_RS15575 Protein ID WP_012640626.1
Coordinates 3202309..3202644 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0H3CC80
Locus tag CC_RS15580 Protein ID WP_024265886.1
Coordinates 3202592..3202843 (-) Length 84 a.a.

Genomic Context

CC_RS15545CC_RS15550CC_RS15555CC_RS15560CC_RS15565CC_RS15570CC_RS15575CC_RS15580CC_RS15585CC_RS15590CC_RS15595CC_RS15600CC_RS15605
Location: 3197657..3198181 (525 bp)
Type: Others
Protein ID: WP_010920815.1
Location: 3198181..3198903 (723 bp)
Type: Others
Protein ID: WP_012640625.1
Location: 3198900..3199451 (552 bp)
Type: Others
Protein ID: WP_010920817.1
Location: 3199545..3201794 (2250 bp)
Type: Others
Protein ID: WP_010920818.1
Location: 3201973..3202158 (186 bp)
Type: Others
Protein ID: WP_024265885.1
Location: 3202160..3202273 (114 bp)
Type: Others
Protein ID: WP_010920820.1
Location: 3202309..3202644 (336 bp)
Type: Toxin
Protein ID: WP_012640626.1
Location: 3202592..3202843 (252 bp)
Type: Antitoxin
Protein ID: WP_024265886.1
Location: 3202861..3203040 (180 bp)
Type: Others
Protein ID: WP_024265887.1
Location: 3203079..3203486 (408 bp)
Type: Others
Protein ID: WP_024265888.1
Location: 3203860..3204612 (753 bp)
Type: Others
Protein ID: WP_024265889.1
Location: 3204903..3205052 (150 bp)
Type: Others
Protein ID: Protein_3063
Location: 3205343..3207067 (1725 bp)
Type: Others
Protein ID: WP_010920825.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CC_RS15545 (CC_2978)3197657..3198181+525WP_010920815.1DUF3429 domain-containing protein-
CC_RS155503198181..3198903+723WP_012640625.1SDR family oxidoreductase-
CC_RS15555 (CC_2980)3198900..3199451+552WP_010920817.1Lrp/AsnC family transcriptional regulator-
CC_RS15560 (CC_2981)3199545..3201794+2250WP_010920818.1excinuclease ABC subunit UvrB-
CC_RS155653201973..3202158+186WP_024265885.1hypothetical protein-
CC_RS15570 (CC_2983)3202160..3202273+114WP_010920820.1type II toxin-antitoxin system VapB family antitoxin-
CC_RS15575 (CC_2984)3202309..3202644-336WP_012640626.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CC_RS15580 (CC_2985)3202592..3202843-252WP_024265886.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
CC_RS155853202861..3203040-180WP_024265887.1hypothetical protein-
CC_RS15590 (CC_2986)3203079..3203486-408WP_024265888.1lysozyme inhibitor LprI family protein-
CC_RS15595 (CC_2987)3203860..3204612-753WP_024265889.1hypothetical protein-
CC_RS156003204903..3205052-150Protein_3063UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase-
CC_RS15605 (CC_2988)3205343..3207067-1725WP_010920825.1response regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(17-105)

Antitoxin

Antitoxin ParD

(6-62)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12367.30 Da        Isoelectric Point: 8.9620

>T233 WP_012640626.1 NC_002696:c3202644-3202309 [Caulobacter vibrioides CB15]
MRFALRRGGGLVWIMSYRLSRKAEQDLIDIYVAGVGLFGVAQAERYQDTLEAAFGAIAAFPHIGRERPELRPPVRVHPCK
SHIILYVLDERGALIVRVRHAGEDWVGEAGG

Download         Length: 336 bp

>T233 NC_002696:c3202644-3202309 [Caulobacter vibrioides CB15]
ATGAGATTCGCGCTGAGGCGCGGCGGCGGGCTGGTGTGGATCATGAGCTATAGGCTCAGCCGGAAGGCCGAGCAGGACCT
GATCGACATCTATGTCGCCGGCGTCGGCCTGTTCGGCGTCGCCCAGGCCGAGCGGTATCAGGACACGCTGGAAGCGGCCT
TCGGCGCCATCGCCGCCTTCCCGCACATTGGCCGCGAGCGCCCCGAACTCCGGCCGCCGGTGCGTGTGCACCCGTGCAAG
TCTCACATCATCCTGTACGTGCTGGACGAGCGCGGAGCGCTGATCGTGCGCGTGCGGCACGCAGGGGAGGATTGGGTCGG
AGAGGCCGGCGGGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9569.61 Da        Isoelectric Point: 6.0817

>AT233 WP_024265886.1 NC_002696:c3202843-3202592 [Caulobacter vibrioides CB15]
MATMNVSLPDAMREWVEGQTQSGRYHNASEYVRDLIRRDQERADKIAHLQRLIDEGLDSGVGERSLHEIRAEARRRAGVD
HEL

Download         Length: 252 bp

>AT233 NC_002696:c3202843-3202592 [Caulobacter vibrioides CB15]
ATGGCGACGATGAATGTTTCCCTGCCCGATGCGATGCGCGAGTGGGTCGAGGGCCAGACCCAGTCGGGCCGCTATCACAA
CGCCAGCGAATACGTCCGTGACCTCATCCGTCGCGACCAGGAACGCGCCGACAAGATCGCCCACCTGCAACGCCTGATCG
ACGAAGGCCTAGACAGCGGCGTTGGCGAGCGCTCGCTGCATGAGATTCGCGCTGAGGCGCGGCGGCGGGCTGGTGTGGAT
CATGAGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T105Mycobacterium tuberculosis H37Rv

37.079

90.816

0.337

T228Caulobacter crescentus CB15

38.095

87.5

0.333
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Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT228Caulobacter crescentus CB15

35.443

95.181

0.337

AT10079Pseudoalteromonas rubra strain SCSIO 6842

45

72.289

0.325
Showing 1 to 2 of 2 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3CBC5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3CC80

References

(1) Aretha Fiebig et al. (2010) Interaction specificity, toxicity and regulation of a paralogous set of ParE/RelE-family toxin-antitoxin systems. Molecular Microbiology 77(1):236-51. [PubMed:20487277] experimental


experimental experimental literature