Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RHH-RelE |
| Location | 3202309..3202882 | Replicon | chromosome |
| Accession | NC_002696 | ||
| Organism | Caulobacter crescentus CB15 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A0H3CBC5 |
| Locus tag | CC_RS15575 | Protein ID | WP_012640626.1 |
| Coordinates | 3202309..3202644 (-) | Length | 112 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A0H3CC80 |
| Locus tag | CC_RS15580 | Protein ID | WP_024265886.1 |
| Coordinates | 3202592..3202843 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CC_RS15545 (CC_2978) | 3197657..3198181 | + | 525 | WP_010920815.1 | DUF3429 domain-containing protein | - |
| CC_RS15550 | 3198181..3198903 | + | 723 | WP_012640625.1 | SDR family oxidoreductase | - |
| CC_RS15555 (CC_2980) | 3198900..3199451 | + | 552 | WP_010920817.1 | Lrp/AsnC family transcriptional regulator | - |
| CC_RS15560 (CC_2981) | 3199545..3201794 | + | 2250 | WP_010920818.1 | excinuclease ABC subunit UvrB | - |
| CC_RS15565 | 3201973..3202158 | + | 186 | WP_024265885.1 | hypothetical protein | - |
| CC_RS15570 (CC_2983) | 3202160..3202273 | + | 114 | WP_010920820.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| CC_RS15575 (CC_2984) | 3202309..3202644 | - | 336 | WP_012640626.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CC_RS15580 (CC_2985) | 3202592..3202843 | - | 252 | WP_024265886.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| CC_RS15585 | 3202861..3203040 | - | 180 | WP_024265887.1 | hypothetical protein | - |
| CC_RS15590 (CC_2986) | 3203079..3203486 | - | 408 | WP_024265888.1 | lysozyme inhibitor LprI family protein | - |
| CC_RS15595 (CC_2987) | 3203860..3204612 | - | 753 | WP_024265889.1 | hypothetical protein | - |
| CC_RS15600 | 3204903..3205052 | - | 150 | Protein_3063 | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase | - |
| CC_RS15605 (CC_2988) | 3205343..3207067 | - | 1725 | WP_010920825.1 | response regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12367.30 Da Isoelectric Point: 8.9620
>T233 WP_012640626.1 NC_002696:c3202644-3202309 [Caulobacter vibrioides CB15]
MRFALRRGGGLVWIMSYRLSRKAEQDLIDIYVAGVGLFGVAQAERYQDTLEAAFGAIAAFPHIGRERPELRPPVRVHPCK
SHIILYVLDERGALIVRVRHAGEDWVGEAGG
MRFALRRGGGLVWIMSYRLSRKAEQDLIDIYVAGVGLFGVAQAERYQDTLEAAFGAIAAFPHIGRERPELRPPVRVHPCK
SHIILYVLDERGALIVRVRHAGEDWVGEAGG
Download Length: 336 bp
>T233 NC_002696:c3202644-3202309 [Caulobacter vibrioides CB15]
ATGAGATTCGCGCTGAGGCGCGGCGGCGGGCTGGTGTGGATCATGAGCTATAGGCTCAGCCGGAAGGCCGAGCAGGACCT
GATCGACATCTATGTCGCCGGCGTCGGCCTGTTCGGCGTCGCCCAGGCCGAGCGGTATCAGGACACGCTGGAAGCGGCCT
TCGGCGCCATCGCCGCCTTCCCGCACATTGGCCGCGAGCGCCCCGAACTCCGGCCGCCGGTGCGTGTGCACCCGTGCAAG
TCTCACATCATCCTGTACGTGCTGGACGAGCGCGGAGCGCTGATCGTGCGCGTGCGGCACGCAGGGGAGGATTGGGTCGG
AGAGGCCGGCGGGTAG
ATGAGATTCGCGCTGAGGCGCGGCGGCGGGCTGGTGTGGATCATGAGCTATAGGCTCAGCCGGAAGGCCGAGCAGGACCT
GATCGACATCTATGTCGCCGGCGTCGGCCTGTTCGGCGTCGCCCAGGCCGAGCGGTATCAGGACACGCTGGAAGCGGCCT
TCGGCGCCATCGCCGCCTTCCCGCACATTGGCCGCGAGCGCCCCGAACTCCGGCCGCCGGTGCGTGTGCACCCGTGCAAG
TCTCACATCATCCTGTACGTGCTGGACGAGCGCGGAGCGCTGATCGTGCGCGTGCGGCACGCAGGGGAGGATTGGGTCGG
AGAGGCCGGCGGGTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9569.61 Da Isoelectric Point: 6.0817
>AT233 WP_024265886.1 NC_002696:c3202843-3202592 [Caulobacter vibrioides CB15]
MATMNVSLPDAMREWVEGQTQSGRYHNASEYVRDLIRRDQERADKIAHLQRLIDEGLDSGVGERSLHEIRAEARRRAGVD
HEL
MATMNVSLPDAMREWVEGQTQSGRYHNASEYVRDLIRRDQERADKIAHLQRLIDEGLDSGVGERSLHEIRAEARRRAGVD
HEL
Download Length: 252 bp
>AT233 NC_002696:c3202843-3202592 [Caulobacter vibrioides CB15]
ATGGCGACGATGAATGTTTCCCTGCCCGATGCGATGCGCGAGTGGGTCGAGGGCCAGACCCAGTCGGGCCGCTATCACAA
CGCCAGCGAATACGTCCGTGACCTCATCCGTCGCGACCAGGAACGCGCCGACAAGATCGCCCACCTGCAACGCCTGATCG
ACGAAGGCCTAGACAGCGGCGTTGGCGAGCGCTCGCTGCATGAGATTCGCGCTGAGGCGCGGCGGCGGGCTGGTGTGGAT
CATGAGCTATAG
ATGGCGACGATGAATGTTTCCCTGCCCGATGCGATGCGCGAGTGGGTCGAGGGCCAGACCCAGTCGGGCCGCTATCACAA
CGCCAGCGAATACGTCCGTGACCTCATCCGTCGCGACCAGGAACGCGCCGACAAGATCGCCCACCTGCAACGCCTGATCG
ACGAAGGCCTAGACAGCGGCGTTGGCGAGCGCTCGCTGCATGAGATTCGCGCTGAGGCGCGGCGGCGGGCTGGTGTGGAT
CATGAGCTATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T105 | Mycobacterium tuberculosis H37Rv |
37.079 |
90.816 |
0.337 |
| T228 | Caulobacter crescentus CB15 |
38.095 |
87.5 |
0.333 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT228 | Caulobacter crescentus CB15 |
35.443 |
95.181 |
0.337 |
| AT10079 | Pseudoalteromonas rubra strain SCSIO 6842 |
45 |
72.289 |
0.325 |
Multiple sequence alignment
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3CBC5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3CC80 |
References
(1) Aretha Fiebig et al. (2010) Interaction specificity, toxicity and regulation of a paralogous set of ParE/RelE-family toxin-antitoxin systems. Molecular Microbiology 77(1):236-51. [PubMed:20487277]