Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) parDE/RHH-RelE
Location 968678..969231 Replicon chromosome
Accession NC_002696
Organism Caulobacter crescentus CB15

Toxin (Protein)


Gene name parE Uniprot ID Q9A9T8
Locus tag CC_RS04550 Protein ID WP_010918758.1
Coordinates 968678..968968 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58091
Locus tag CC_RS04555 Protein ID WP_010918759.1
Coordinates 968965..969231 (-) Length 89 a.a.

Genomic Context

CC_RS04545CC_RS04560CC_RS04565CC_RS04570CC_RS04575CC_RS04520CC_RS04525CC_RS04530CC_RS04535CC_RS04540CC_RS04550CC_RS04555
Location: 967916..968677 (762 bp)
Type: Others
Protein ID: WP_024265642.1
Location: 969305..970174 (870 bp)
Type: Others
Protein ID: WP_012640077.1
Location: 970212..970436 (225 bp)
Type: Others
Protein ID: WP_012640078.1
Location: 970433..971545 (1113 bp)
Type: Others
Protein ID: WP_010918761.1
Location: 971713..972468 (756 bp)
Type: Others
Protein ID: WP_010918762.1
Location: 964045..965235 (1191 bp)
Type: Others
Protein ID: WP_010918752.1
Location: 965298..965888 (591 bp)
Type: Others
Protein ID: WP_010918753.1
Location: 965885..966952 (1068 bp)
Type: Others
Protein ID: WP_012640075.1
Location: 967002..967178 (177 bp)
Type: Others
Protein ID: WP_010918755.1
Location: 967257..967784 (528 bp)
Type: Others
Protein ID: WP_012640076.1
Location: 968678..968968 (291 bp)
Type: Toxin
Protein ID: WP_010918758.1
Location: 968965..969231 (267 bp)
Type: Antitoxin
Protein ID: WP_010918759.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CC_RS04520 (CC_0867)964045..965235-1191WP_010918752.1erythromycin esterase family protein-
CC_RS04525 (CC_0868)965298..965888-591WP_010918753.1AAA family ATPase-
CC_RS04530 (CC_0869)965885..966952-1068WP_012640075.1serine hydrolase-
CC_RS04535 (CC_0870)967002..967178-177WP_010918755.1hypothetical protein-
CC_RS04540 (CC_0871)967257..967784-528WP_012640076.1GNAT family N-acetyltransferase-
CC_RS04545 (CC_0872)967916..968677+762WP_024265642.1MOSC domain-containing protein-
CC_RS04550 (CC_0873)968678..968968-291WP_010918758.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CC_RS04555 (CC_0874)968965..969231-267WP_010918759.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
CC_RS04560 (CC_0875)969305..970174+870WP_012640077.1peptide chain release factor N(5)-glutamine methyltransferase-
CC_RS04565970212..970436+225WP_012640078.1hypothetical protein-
CC_RS04570 (CC_0876)970433..971545+1113WP_010918761.1DUF4167 domain-containing protein-
CC_RS04575 (CC_0877)971713..972468+756WP_010918762.1M48 family metallopeptidase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Antitoxin ParD

(2-81)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11057.55 Da        Isoelectric Point: 8.9111

>T228 WP_010918758.1 NC_002696:c968968-968678 [Caulobacter vibrioides CB15]
MKPYRLSRRAKADLDDIWTYSEQRWGVEQAADYARELQATIEMIAEHPGMGQPDENLRAGYRRCASGSHVVFYRVGVRVE
IIRVLHQSMNARAHLG

Download         Length: 291 bp

>T228 NC_002696:c968968-968678 [Caulobacter vibrioides CB15]
ATGAAGCCCTATCGGCTATCCCGTCGCGCCAAGGCCGACCTCGATGACATCTGGACCTATTCAGAGCAGCGATGGGGCGT
TGAACAAGCCGCCGACTACGCCCGTGAACTGCAGGCCACCATCGAGATGATCGCTGAACATCCGGGTATGGGACAGCCGG
ATGAAAACCTCCGCGCGGGCTACAGGCGATGCGCCAGCGGCTCGCACGTGGTCTTTTACCGCGTCGGCGTGCGGGTCGAG
ATTATCCGCGTGCTACACCAAAGCATGAACGCCAGGGCTCACCTTGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9635.57 Da        Isoelectric Point: 4.1523

>AT228 WP_010918759.1 NC_002696:c969231-968965 [Caulobacter vibrioides CB15]
MASKNTSVVLGDHFQAFIDSQVADGRYGSASEVIRAGLRLLEENEAKLAALRAALIEGEESGFIEDFDFDAFIEERSRAS
APQGFHEE

Download         Length: 267 bp

>AT228 NC_002696:c969231-968965 [Caulobacter vibrioides CB15]
ATGGCGAGCAAGAACACCTCCGTCGTCCTGGGCGATCACTTCCAGGCGTTCATCGACAGCCAGGTCGCTGACGGGCGCTA
CGGCTCGGCCAGCGAAGTCATCCGCGCGGGGCTGAGGCTCCTCGAAGAGAACGAAGCGAAGCTCGCGGCCCTCCGCGCCG
CCCTGATCGAAGGCGAGGAGAGCGGCTTTATCGAGGACTTCGACTTCGACGCCTTTATCGAGGAAAGGTCTAGGGCATCC
GCTCCGCAGGGGTTCCATGAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T105Mycobacterium tuberculosis H37Rv

43.617

97.917

0.427

T169Vibrio cholerae O1 biovar El Tor str. N16961

38.776

100

0.396

T10079Pseudoalteromonas rubra strain SCSIO 6842

35.165

94.792

0.333

T233Caulobacter crescentus CB15

38.095

87.5

0.333
Showing 1 to 4 of 4 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT105Mycobacterium tuberculosis H37Rv

59.259

97.59

0.578

AT169Vibrio cholerae O1 biovar El Tor str. N16961

63.014

91.25

0.575

AT10079Pseudoalteromonas rubra strain SCSIO 6842

45.349

100

0.453

AT233Caulobacter crescentus CB15

35.443

95.181

0.337
Showing 1 to 4 of 4 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
PDB3KXE

Antitoxin

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Source
ID
Structure
PDB3KXE
AlphaFold DBA0A290N011

References

(1) Kevin M Dalton et al. (2010) A conserved mode of protein recognition and binding in a ParD-ParE toxin-antitoxin complex. Biochemistry 49(10):2205-15. [PubMed:20143871] 3D_structure


3D_structure protein structure literature