Detailed information of TA system TA006285

Experimentally validated

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 4216503..4217028
• Replicon: chromosome
• Accession: NC_017586
• Organism: Streptomyces cattleya NRRL 8057 = DSM 46488

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F8K3H9
• Locus tag: SCATT_RS18610
• Protein ID: WP_014144656.1
• Coordinates: 4216503..4216766 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G8WSR4
• Locus tag: SCATT_RS18615
• Protein ID: WP_014628308.1
• Coordinates: 4216759..4217028 (-)
• Length: 90 a.a.

Genomic Context

Location: 4211682..4213037 (1356 bp)
Type: Others
Protein ID: WP_014144652.1

Location: 4213039..4213569 (531 bp)
Type: Others
Protein ID: WP_014144653.1

Location: 4213700..4214527 (828 bp)
Type: Others
Protein ID: WP_014144654.1

Location: 4215233..4216195 (963 bp)
Type: Others
Protein ID: WP_157894840.1

Location: 4217210..4218628 (1419 bp)
Type: Others
Protein ID: WP_014144658.1

Location: 4218749..4220461 (1713 bp)
Type: Others
Protein ID: WP_014142185.1

Location: 4220586..4220939 (354 bp)
Type: Others
Protein ID: WP_014144659.1

Location: 4216503..4216766 (264 bp)
Type: Toxin
Protein ID: WP_014144656.1

Location: 4216759..4217028 (270 bp)
Type: Antitoxin
Protein ID: WP_014628308.1

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SCATT_RS18590 (SCATT_39240)	4211682..4213037	+	1356	WP_014144652.1	hypothetical protein	-
SCATT_RS18595 (SCATT_39250)	4213039..4213569	+	531	WP_014144653.1	NUDIX domain-containing protein	-
SCATT_RS18600	4213700..4214527	+	828	WP_014144654.1	TIGR04255 family protein	-
SCATT_RS18605 (SCATT_39260)	4215233..4216195	+	963	WP_157894840.1	hypothetical protein	-
SCATT_RS18610 (SCATT_39270)	4216503..4216766	-	264	WP_014144656.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SCATT_RS18615 (SCATT_39280)	4216759..4217028	-	270	WP_014628308.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SCATT_RS18620 (SCATT_39290)	4217210..4218628	+	1419	WP_014144658.1	ATP-binding protein	-
SCATT_RS18625 (SCATT_39310)	4218749..4220461	+	1713	WP_014142185.1	IS1182 family transposase	-
SCATT_RS38640 (SCATT_39320)	4220586..4220939	+	354	WP_014144659.1	hypothetical protein	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_016111 Streptomyces cattleya NRRL 8057 = DSM 46488 Integrative and Conjugative Element TA025678 4200367..4241917 0	inside	Integrative and Conjugative Element	-	-	4200177..4241727	41550

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9968.42 Da
• Isoelectric Point: 9.5565

>T6285 WP_014144656.1 NC_017586:c4216766-4216503 [Streptomyces cattleya NRRL 8057 = DSM 46488]
VSEYRTVFRPEAQAELRKVPRDMALRILAKLTELESDPLGFNTTALVSQPDRRRLRVGDYRVIYTIDNGELVVWVVHVGH
RSTVYGA

Nucleotide

• Length: 264 bp

>T6285 NC_017586:c4216766-4216503 [Streptomyces cattleya NRRL 8057 = DSM 46488]
GTGAGTGAGTACCGCACCGTCTTCCGACCCGAGGCTCAGGCCGAACTCCGCAAGGTCCCGCGCGACATGGCTCTCCGCAT
TCTGGCCAAGCTGACCGAGCTGGAGAGCGACCCGCTGGGATTCAACACCACTGCTCTCGTCTCCCAGCCCGACCGGCGCC
GCCTACGGGTCGGCGACTACCGCGTGATCTACACGATCGACAATGGTGAGCTGGTGGTGTGGGTCGTGCATGTCGGGCAT
CGCTCAACCGTCTACGGCGCCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10322.79 Da
• Isoelectric Point: 4.7473

>AT6285 WP_014628308.1 NC_017586:c4217028-4216759 [Streptomyces cattleya NRRL 8057 = DSM 46488]
MTQPLPMESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRIIDERMANPTPGVPIEDI
MRETLARSE

Nucleotide

• Length: 270 bp

>AT6285 NC_017586:c4217028-4216759 [Streptomyces cattleya NRRL 8057 = DSM 46488]
ATGACACAACCGCTGCCCATGGAGTCCATCCGCGATGTCCGGGCACACCTCGCCGAGGTCGTGGAGCGGGCTGACCGCGA
CGACGTGCCCACGGTGATCACGCGCCGAGGCAAGCAGGTGGCTGCCGTGGTGTCCATCGAAGTGCTCCGGAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGAATCATCGATGAGCGCATGGCCAACCCGACACCCGGCGTCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCAGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
T10191	Synechococcus sp. CB0101	40	95.238	0.381
T124	Mycobacterium tuberculosis H37Rv	31.461	100	0.322
T10157	Streptococcus suis SC84	32.184	100	0.322
T1729	Acidithiobacillus caldus	32.558	98.851	0.322
T93	Mycobacterium tuberculosis H37Rv	31.818	100	0.322

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Multiple sequence alignment

Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
AT172	Vibrio cholerae O1 biovar El Tor str. N16961	31.395	96.629	0.303

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Multiple sequence alignment

Structures

Toxin

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• AlphaFold DB: F8K3H9

Antitoxin

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• AlphaFold DB: G8WSR4

References

(1) Peng Li et al. (2016) Identification and characterization of chromosomal relBE toxin-antitoxin locus in Streptomyces cattleya DSM46488. Scientific Reports 6:32047. [PubMed:27534445]


 experimental literature